Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:14056
  • Symbol:Ezh2
  • Description:enhancer of zeste 2 polycomb repressive complex 2 subunit

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14056 GO:0000082 IMP acts_upstream_of G1/S transition of mitotic cell cycle 19303854 Process
14056 GO:0000122 IDA acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II 24105743 Process
14056 GO:0001932 IMP acts_upstream_of_or_within regulation of protein phosphorylation 19303854 Process
14056 GO:0006306 IMP acts_upstream_of_or_within DNA methylation 24105743 Process
14056 GO:0006357 IMP acts_upstream_of_or_within regulation of transcription by RNA polymerase II 21498568 Process
14056 GO:0009913 IMP acts_upstream_of epidermal cell differentiation 19303854 Process
14056 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 20798045,24137001 Process
14056 GO:0014013 IMP acts_upstream_of_or_within regulation of gliogenesis 20798045 Process
14056 GO:0014834 IMP acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration 21498568 Process
14056 GO:0014898 IDA acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress 24137001 Process
14056 GO:0021695 IMP acts_upstream_of_or_within cerebellar cortex development 20798045 Process
14056 GO:0030097 IMP involved_in hemopoiesis 23531880 Process
14056 GO:0030183 IMP involved_in B cell differentiation 23531880 Process
14056 GO:0030216 IMP acts_upstream_of keratinocyte differentiation 19303854 Process
14056 GO:0034244 IMP acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II 19303854 Process
14056 GO:0035984 IMP acts_upstream_of_or_within cellular response to trichostatin A 24137001 Process
14056 GO:0036333 IGI acts_upstream_of_or_within hepatocyte homeostasis 25477280 Process
14056 GO:0042127 IMP acts_upstream_of_or_within regulation of cell population proliferation 19303854 Process
14056 GO:0042752 IMP involved_in regulation of circadian rhythm 16717091 Process
14056 GO:0043433 IGI acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity 25547114 Process
14056 GO:0045605 IMP acts_upstream_of_or_within negative regulation of epidermal cell differentiation 19303854 Process
14056 GO:0045617 IMP acts_upstream_of_or_within negative regulation of keratinocyte differentiation 19303854 Process
14056 GO:0048863 IMP acts_upstream_of stem cell differentiation 19303854 Process
14056 GO:0050767 IMP acts_upstream_of_or_within regulation of neurogenesis 20798045 Process
14056 GO:0051154 IDA acts_upstream_of_or_within negative regulation of striated muscle cell differentiation 15520282 Process
14056 GO:0070301 IDA acts_upstream_of_or_within cellular response to hydrogen peroxide 20808772 Process
14056 GO:0070314 IMP acts_upstream_of_or_within G1 to G0 transition 19303854 Process
14056 GO:0071168 IMP acts_upstream_of_or_within protein localization to chromatin 18311137 Process
14056 GO:0097421 IGI acts_upstream_of_or_within liver regeneration 25477280 Process
14056 GO:0140718 IDA involved_in facultative heterochromatin formation 20064375,20064376 Process
14056 GO:1904772 IGI acts_upstream_of_or_within response to tetrachloromethane 25477280 Process
14056 GO:2000134 IMP acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle 19303854 Process
14056 GO:2000737 IMP acts_upstream_of_or_within negative regulation of stem cell differentiation 19303854 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14056 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 24137001 Function
14056 GO:0000979 IDA enables RNA polymerase II core promoter sequence-specific DNA binding 20798045 Function
14056 GO:0000979 IMP enables RNA polymerase II core promoter sequence-specific DNA binding 16717091 Function
14056 GO:0003677 IDA enables DNA binding 23942234 Function
14056 GO:0003682 IDA enables chromatin binding 15520282,22056776,23046516,24105743,25547114 Function
14056 GO:0003714 IDA enables transcription corepressor activity 19026781 Function
14056 GO:0003723 IDA enables RNA binding 21936910 Function
14056 GO:0003723 IPI enables RNA binding 21123648,22911650,26423156 Function
14056 GO:0005515 IPI enables protein binding 9584197,9742080,12900441,16717091,17107999,17937919,17997413,2..... Function
14056 GO:0016279 IDA enables protein-lysine N-methyltransferase activity 25547114 Function
14056 GO:0031490 IDA enables chromatin DNA binding 18483221,24137001 Function
14056 GO:0042054 IDA enables histone methyltransferase activity 12900441 Function
14056 GO:0043021 IDA enables ribonucleoprotein complex binding 21172659 Function
14056 GO:0043565 IDA enables sequence-specific DNA binding 20956546 Function
14056 GO:0046976 IMP enables histone H3K27 methyltransferase activity 16717091 Function
14056 GO:0070878 IDA enables primary miRNA binding 24137001 Function
14056 GO:0106222 IDA enables lncRNA binding 27618650 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
14056 GO:0005634 IDA is_active_in nucleus 23046516 Component
14056 GO:0005634 IDA located_in nucleus 9584197,15520282,18483221,19303854,22482507,22949634..... Component
14056 GO:0005677 IDA part_of chromatin silencing complex 26658965 Component
14056 GO:0005721 IDA part_of pericentric heterochromatin 27892467 Component
14056 GO:0035098 IDA part_of ESC/E(Z) complex 19026781,20064375,20064376,20144788,22438827,23160351,31451685..... Component
14056 GO:0045120 IDA located_in pronucleus 12900441 Component