Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:16396
  • Symbol:Itch
  • Description:itchy, E3 ubiquitin protein ligase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16396 GO:0000209 IDA acts_upstream_of_or_within protein polyubiquitination 14973438 Process
16396 GO:0002669 IMP acts_upstream_of_or_within positive regulation of T cell anergy 14973438 Process
16396 GO:0002870 IMP acts_upstream_of T cell anergy 14973438 Process
16396 GO:0006511 IDA acts_upstream_of_or_within ubiquitin-dependent protein catabolic process 14973438,15678106 Process
16396 GO:0030163 IMP acts_upstream_of protein catabolic process 14973438 Process
16396 GO:0032088 IMP involved_in negative regulation of NF-kappaB transcription factor activity 18246070 Process
16396 GO:0035739 IMP acts_upstream_of CD4-positive, alpha-beta T cell proliferation 14973438 Process
16396 GO:0045732 IDA acts_upstream_of_or_within positive regulation of protein catabolic process 14973438 Process
16396 GO:0045732 IMP acts_upstream_of_or_within positive regulation of protein catabolic process 14973438 Process
16396 GO:0046329 IMP involved_in negative regulation of JNK cascade 18246070 Process
16396 GO:0050687 IMP involved_in negative regulation of defense response to virus 19881509 Process
16396 GO:0070936 IMP involved_in protein K48-linked ubiquitination 18246070 Process
16396 GO:0090085 IMP involved_in regulation of protein deubiquitination 18246070 Process
16396 GO:2000562 IMP acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation 14973438 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16396 GO:0005515 IPI enables protein binding 11782481,17137798,18246070,18278048,22057290,26854353,31845480..... Function
16396 GO:0016874 IMP enables ligase activity 18246070 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16396 GO:0005634 IDA located_in nucleus 11555636 Component
16396 GO:0005737 IDA located_in cytoplasm 14973438 Component
16396 GO:0005938 IDA located_in cell cortex 17137798 Component
16396 GO:0016020 IDA located_in membrane 14973438 Component
16396 GO:0031410 IDA located_in cytoplasmic vesicle 17137798 Component