Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:16835
  • Symbol:Ldlr
  • Description:low density lipoprotein receptor

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16835 GO:0001540 IPI enables amyloid-beta binding 22383525 Function
16835 GO:0005041 IDA enables low-density lipoprotein particle receptor activity 12072432 Function
16835 GO:0005041 IMP enables low-density lipoprotein particle receptor activity 17148552 Function
16835 GO:0005515 IPI enables protein binding 12169628,12746448 Function
16835 GO:0030169 IDA enables low-density lipoprotein particle binding 7848292,15741654 Function
16835 GO:0030229 IDA enables very-low-density lipoprotein particle receptor activity 16166565 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16835 GO:0005615 HDA located_in extracellular space 24006456 Component
16835 GO:0005764 IDA located_in lysosome 11092755 Component
16835 GO:0005768 IDA located_in endosome 12746448 Component
16835 GO:0005769 IDA located_in early endosome 11092755,26965651 Component
16835 GO:0005770 IDA located_in late endosome 11092755 Component
16835 GO:0005886 IDA located_in plasma membrane 20005821 Component
16835 GO:0009986 IDA located_in cell surface 22848640,26965651 Component
16835 GO:0016323 IDA located_in basolateral plasma membrane 22848640 Component
16835 GO:0036477 IDA located_in somatodendritic compartment 18341993 Component
16835 GO:0045177 IDA located_in apical part of cell 22848640 Component
16835 GO:0097443 IDA located_in sorting endosome 11092755 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16835 GO:0006629 IGI acts_upstream_of_or_within lipid metabolic process 11120757 Process
16835 GO:0006898 IDA involved_in receptor-mediated endocytosis 20005821,22383525 Process
16835 GO:0006909 IDA involved_in phagocytosis 22383525 Process
16835 GO:0007616 IGI involved_in long-term memory 24412220 Process
16835 GO:0008203 IMP acts_upstream_of_or_within cholesterol metabolic process 17071966 Process
16835 GO:0010628 IGI involved_in positive regulation of gene expression 24255059 Process
16835 GO:0010628 IMP involved_in positive regulation of gene expression 24255059 Process
16835 GO:0010629 IMP involved_in negative regulation of gene expression 24255059 Process
16835 GO:0010867 IMP involved_in positive regulation of triglyceride biosynthetic process 18175806 Process
16835 GO:0010899 IMP involved_in regulation of phosphatidylcholine catabolic process 18175806 Process
16835 GO:0015914 IMP involved_in phospholipid transport 18175806 Process
16835 GO:0030301 IMP acts_upstream_of_or_within cholesterol transport 17148552 Process
16835 GO:0034381 IDA involved_in plasma lipoprotein particle clearance 22383525 Process
16835 GO:0034383 IDA acts_upstream_of_or_within low-density lipoprotein particle clearance 26965651 Process
16835 GO:0034383 IMP involved_in low-density lipoprotein particle clearance 18175806 Process
16835 GO:0034384 IGI involved_in high-density lipoprotein particle clearance 25524771 Process
16835 GO:0042157 IGI acts_upstream_of_or_within lipoprotein metabolic process 11120757,13130124 Process
16835 GO:0042159 IDA acts_upstream_of_or_within lipoprotein catabolic process 15741654 Process
16835 GO:0042159 IMP acts_upstream_of_or_within lipoprotein catabolic process 9788969,15805190 Process
16835 GO:0042632 IGI acts_upstream_of_or_within cholesterol homeostasis 11120757 Process
16835 GO:0042632 IGI involved_in cholesterol homeostasis 25524771 Process
16835 GO:0042632 IMP acts_upstream_of_or_within cholesterol homeostasis 9788969,12746448,23580231 Process
16835 GO:0048844 IMP involved_in artery morphogenesis 22927332 Process
16835 GO:0050729 IGI involved_in positive regulation of inflammatory response 24255059 Process
16835 GO:0051246 IGI involved_in regulation of protein metabolic process 24412220 Process
16835 GO:0051248 IDA involved_in negative regulation of protein metabolic process 22383525 Process
16835 GO:0051649 IMP acts_upstream_of_or_within establishment of localization in cell 17148552 Process
16835 GO:0061771 IGI involved_in response to caloric restriction 24412220 Process
16835 GO:0061889 IGI involved_in negative regulation of astrocyte activation 20005821 Process
16835 GO:0070508 IMP involved_in cholesterol import 18175806 Process
16835 GO:0071398 IGI involved_in cellular response to fatty acid 24255059 Process
16835 GO:0090181 IGI involved_in regulation of cholesterol metabolic process 24412220 Process
16835 GO:0097242 IGI involved_in amyloid-beta clearance 20005821 Process
16835 GO:0150094 IDA involved_in amyloid-beta clearance by cellular catabolic process 22383525 Process
16835 GO:1903979 IGI involved_in negative regulation of microglial cell activation 20005821 Process
16835 GO:1905167 IDA involved_in positive regulation of lysosomal protein catabolic process 22383525 Process
16835 GO:1905907 IGI involved_in negative regulation of amyloid fibril formation 20005821 Process