Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:16971
  • Symbol:Lrp1
  • Description:low density lipoprotein receptor-related protein 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16971 GO:0002265 IGI involved_in astrocyte activation involved in immune response 23152628 Process
16971 GO:0003279 IMP acts_upstream_of_or_within cardiac septum development 25807483 Process
16971 GO:0006898 IDA acts_upstream_of_or_within receptor-mediated endocytosis 21795536 Process
16971 GO:0006898 IGI involved_in receptor-mediated endocytosis 21289173,24305823 Process
16971 GO:0006898 IMP involved_in receptor-mediated endocytosis 21289173 Process
16971 GO:0007041 IDA involved_in lysosomal transport 26370502 Process
16971 GO:0007167 IMP involved_in enzyme-linked receptor protein signaling pathway 31023188 Process
16971 GO:0008203 IMP acts_upstream_of_or_within cholesterol metabolic process 17920016 Process
16971 GO:0010629 IMP involved_in negative regulation of gene expression 31023188 Process
16971 GO:0010875 IMP involved_in positive regulation of cholesterol efflux 19718435 Process
16971 GO:0014912 IMP involved_in negative regulation of smooth muscle cell migration 19742316 Process
16971 GO:0030178 IDA acts_upstream_of_or_within negative regulation of Wnt signaling pathway 16207730 Process
16971 GO:0030512 IGI involved_in negative regulation of transforming growth factor beta receptor signaling pathway 31023188 Process
16971 GO:0032370 IMP involved_in positive regulation of lipid transport 19718435 Process
16971 GO:0032374 IMP involved_in regulation of cholesterol transport 19718435 Process
16971 GO:0032376 IDA involved_in positive regulation of cholesterol transport 19718435 Process
16971 GO:0032429 IMP involved_in regulation of phospholipase A2 activity 19718435 Process
16971 GO:0032956 IMP involved_in regulation of actin cytoskeleton organization 19742316 Process
16971 GO:0035909 IMP involved_in aorta morphogenesis 19742316 Process
16971 GO:0043277 IMP acts_upstream_of_or_within apoptotic cell clearance 15647754 Process
16971 GO:0060392 IMP involved_in negative regulation of SMAD protein signal transduction 31023188 Process
16971 GO:0060394 IMP involved_in negative regulation of pathway-restricted SMAD protein phosphorylation 31023188 Process
16971 GO:0060976 IMP acts_upstream_of_or_within coronary vasculature development 25807483 Process
16971 GO:0097242 IMP involved_in amyloid-beta clearance 19098903 Process
16971 GO:0150093 IDA involved_in amyloid-beta clearance by transcytosis 20630619 Process
16971 GO:0150094 IDA involved_in amyloid-beta clearance by cellular catabolic process 21289173 Process
16971 GO:0150094 IGI involved_in amyloid-beta clearance by cellular catabolic process 24305823 Process
16971 GO:0150094 IMP involved_in amyloid-beta clearance by cellular catabolic process 23152628 Process
16971 GO:0150104 IMP involved_in transport across blood-brain barrier 20630619,26619118 Process
16971 GO:1900223 IMP involved_in positive regulation of amyloid-beta clearance 26619118 Process
16971 GO:1904300 IMP involved_in positive regulation of transcytosis 26619118 Process
16971 GO:1904646 IGI involved_in cellular response to amyloid-beta 23152628 Process
16971 GO:1905109 IMP involved_in regulation of pulmonary blood vessel remodeling 31023188 Process
16971 GO:2000587 IMP involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway 19742316 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16971 GO:0005102 IPI enables signaling receptor binding 31023188 Function
16971 GO:0005509 IDA enables calcium ion binding 3266596 Function
16971 GO:0005515 IPI enables protein binding 10772929,10827173,17727637,17920016,19047013,19455133,20205790..... Function
16971 GO:0038024 IMP enables cargo receptor activity 21289173 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16971 GO:0005886 IDA located_in plasma membrane 3266596 Component
16971 GO:0009897 IDA located_in external side of plasma membrane 19299737 Component
16971 GO:0016020 IDA located_in membrane 15082773 Component