Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:16974
  • Symbol:Lrp6
  • Description:low density lipoprotein receptor-related protein 6

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16974 GO:0001702 IGI acts_upstream_of_or_within gastrulation with mouth forming second 15142971 Process
16974 GO:0001756 IGI acts_upstream_of_or_within somitogenesis 19795512 Process
16974 GO:0001843 IGI acts_upstream_of_or_within neural tube closure 19795512 Process
16974 GO:0001843 IMP acts_upstream_of_or_within neural tube closure 10545599,15469977,19653321 Process
16974 GO:0001947 IGI acts_upstream_of_or_within heart looping 19795512 Process
16974 GO:0002009 IMP acts_upstream_of_or_within morphogenesis of an epithelium Process
16974 GO:0002053 IMP acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation 19700620 Process
16974 GO:0003344 IGI acts_upstream_of_or_within pericardium morphogenesis 19795512 Process
16974 GO:0003401 IMP acts_upstream_of_or_within axis elongation 19795512 Process
16974 GO:0008078 IGI acts_upstream_of_or_within mesodermal cell migration 15142971 Process
16974 GO:0009880 IMP acts_upstream_of_or_within embryonic pattern specification 19653321 Process
16974 GO:0009950 IMP acts_upstream_of_or_within dorsal/ventral axis specification 18985738 Process
16974 GO:0009952 IGI acts_upstream_of_or_within anterior/posterior pattern specification 15142971 Process
16974 GO:0009952 IMP acts_upstream_of_or_within anterior/posterior pattern specification 16126904,19795512 Process
16974 GO:0010463 IMP acts_upstream_of mesenchymal cell proliferation 19700620 Process
16974 GO:0010976 IGI involved_in positive regulation of neuron projection development 23845000 Process
16974 GO:0021587 IMP acts_upstream_of_or_within cerebellum morphogenesis 11029008 Process
16974 GO:0021794 IMP acts_upstream_of_or_within thalamus development 15342729 Process
16974 GO:0021795 IMP acts_upstream_of_or_within cerebral cortex cell migration 16920270 Process
16974 GO:0021861 IGI acts_upstream_of_or_within forebrain radial glial cell differentiation 14715945 Process
16974 GO:0021872 IMP acts_upstream_of_or_within forebrain generation of neurons 14715945 Process
16974 GO:0021874 IGI acts_upstream_of_or_within Wnt signaling pathway involved in forebrain neuroblast division 14715945 Process
16974 GO:0021874 IMP acts_upstream_of_or_within Wnt signaling pathway involved in forebrain neuroblast division 16920270 Process
16974 GO:0021915 IGI acts_upstream_of_or_within neural tube development 19795512 Process
16974 GO:0021943 IGI acts_upstream_of_or_within formation of radial glial scaffolds 14715945 Process
16974 GO:0021987 IMP acts_upstream_of_or_within cerebral cortex development 16920270 Process
16974 GO:0030326 IGI acts_upstream_of_or_within embryonic limb morphogenesis 20359476 Process
16974 GO:0030900 IMP acts_upstream_of_or_within forebrain development 15384171 Process
16974 GO:0030901 IMP acts_upstream_of_or_within midbrain development 11029008 Process
16974 GO:0030917 IMP acts_upstream_of_or_within midbrain-hindbrain boundary development 11029008,19795512 Process
16974 GO:0035108 IGI acts_upstream_of_or_within limb morphogenesis 15537447 Process
16974 GO:0035108 IMP acts_upstream_of_or_within limb morphogenesis 15469977 Process
16974 GO:0035115 IGI acts_upstream_of_or_within embryonic forelimb morphogenesis 15880584,18256198 Process
16974 GO:0035115 IMP acts_upstream_of_or_within embryonic forelimb morphogenesis 11029008,19653321 Process
16974 GO:0035116 IGI acts_upstream_of_or_within embryonic hindlimb morphogenesis 15880584,18256198 Process
16974 GO:0035116 IMP acts_upstream_of_or_within embryonic hindlimb morphogenesis 19653321 Process
16974 GO:0035261 IMP acts_upstream_of_or_within external genitalia morphogenesis 19653321 Process
16974 GO:0036342 IGI acts_upstream_of_or_within post-anal tail morphogenesis 19795512 Process
16974 GO:0036342 IMP acts_upstream_of_or_within post-anal tail morphogenesis 19653321,19795512 Process
16974 GO:0042074 IGI acts_upstream_of_or_within cell migration involved in gastrulation 15142971 Process
16974 GO:0042475 IMP acts_upstream_of_or_within odontogenesis of dentin-containing tooth 591875,5893447 Process
16974 GO:0042733 IGI acts_upstream_of_or_within embryonic digit morphogenesis 15142971 Process
16974 GO:0042733 IMP acts_upstream_of_or_within embryonic digit morphogenesis 19795512 Process
16974 GO:0043065 IMP acts_upstream_of_or_within positive regulation of apoptotic process 19700620 Process
16974 GO:0045444 IMP acts_upstream_of fat cell differentiation 17888405 Process
16974 GO:0045599 IMP acts_upstream_of_or_within negative regulation of fat cell differentiation 17888405 Process
16974 GO:0045778 IMP acts_upstream_of_or_within positive regulation of ossification 15469977 Process
16974 GO:0045780 IMP acts_upstream_of_or_within positive regulation of bone resorption 18505367 Process
16974 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 15035989 Process
16974 GO:0046849 IGI acts_upstream_of_or_within bone remodeling 15537447 Process
16974 GO:0048596 IMP acts_upstream_of_or_within embryonic camera-type eye morphogenesis 18985738,19653321 Process
16974 GO:0048699 IMP acts_upstream_of_or_within generation of neurons 15342729 Process
16974 GO:0048705 IMP acts_upstream_of_or_within skeletal system morphogenesis 15469977 Process
16974 GO:0050678 IMP acts_upstream_of_or_within regulation of epithelial cell proliferation 591875 Process
16974 GO:0050680 IMP acts_upstream_of_or_within negative regulation of epithelial cell proliferation 19700620 Process
16974 GO:0051091 IMP involved_in positive regulation of DNA-binding transcription factor activity 15035989 Process
16974 GO:0051593 IMP acts_upstream_of_or_within response to folic acid 17050573 Process
16974 GO:0060021 IMP acts_upstream_of_or_within roof of mouth development 19653321,19700620 Process
16974 GO:0060026 IGI acts_upstream_of_or_within convergent extension 19795512 Process
16974 GO:0060042 IMP acts_upstream_of_or_within retina morphogenesis in camera-type eye 18985738 Process
16974 GO:0060059 IMP acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye 19653321 Process
16974 GO:0060070 IGI involved_in canonical Wnt signaling pathway 11029008,15143170,16126904,18256198,19910923 Process
16974 GO:0060070 IMP involved_in canonical Wnt signaling pathway 15064719,15469977,18505367,19700620,19795512 Process
16974 GO:0060284 IMP acts_upstream_of_or_within regulation of cell development 19795519 Process
16974 GO:0060325 IMP acts_upstream_of_or_within face morphogenesis 19653321,19700620 Process
16974 GO:0060349 IMP acts_upstream_of_or_within bone morphogenesis Process
16974 GO:0060444 IMP acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis 19503830 Process
16974 GO:0060535 IGI acts_upstream_of_or_within trachea cartilage morphogenesis 18256198 Process
16974 GO:0060596 IMP acts_upstream_of_or_within mammary placode formation 19503830 Process
16974 GO:0060603 IGI acts_upstream_of_or_within mammary gland duct morphogenesis 19503830 Process
16974 GO:0060856 IMP acts_upstream_of_or_within establishment of blood-brain barrier 25083995 Process
16974 GO:0061310 IMP acts_upstream_of_or_within canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development 19705442 Process
16974 GO:0061324 IMP acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation 19705442 Process
16974 GO:0061347 IGI acts_upstream_of planar cell polarity pathway involved in outflow tract morphogenesis 19056682 Process
16974 GO:0061348 IGI acts_upstream_of planar cell polarity pathway involved in ventricular septum morphogenesis 19056682 Process
16974 GO:0061349 IGI acts_upstream_of planar cell polarity pathway involved in cardiac right atrium morphogenesis 19056682 Process
16974 GO:0061350 IGI acts_upstream_of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis 19056682 Process
16974 GO:0061354 IGI acts_upstream_of planar cell polarity pathway involved in pericardium morphogenesis 19056682 Process
16974 GO:0071542 IMP acts_upstream_of_or_within dopaminergic neuron differentiation 19795519 Process
16974 GO:0072089 IMP acts_upstream_of stem cell proliferation 19700620 Process
16974 GO:0090009 IGI acts_upstream_of_or_within primitive streak formation 19795512 Process
16974 GO:0090118 IMP acts_upstream_of_or_within receptor-mediated endocytosis involved in cholesterol transport 18948618 Process
16974 GO:0090179 IGI acts_upstream_of planar cell polarity pathway involved in neural tube closure 19056682 Process
16974 GO:0090244 IMP acts_upstream_of_or_within Wnt signaling pathway involved in somitogenesis 15469977 Process
16974 GO:0090245 IGI acts_upstream_of_or_within axis elongation involved in somitogenesis 11029008 Process
16974 GO:0110135 IDA involved_in Norrin signaling pathway 15035989 Process
16974 GO:1990963 IMP acts_upstream_of_or_within establishment of blood-retinal barrier 25083995 Process
16974 GO:2000051 IGI acts_upstream_of_or_within negative regulation of non-canonical Wnt signaling pathway 19056682 Process
16974 GO:2000149 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis 19056682 Process
16974 GO:2000151 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis 19056682 Process
16974 GO:2000162 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis 19056682 Process
16974 GO:2000164 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis 19056682 Process
16974 GO:2000166 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in pericardium morphogenesis 19056682 Process
16974 GO:2000168 IGI acts_upstream_of_or_within negative regulation of planar cell polarity pathway involved in neural tube closure 19056682 Process
16974 GO:2000648 IMP acts_upstream_of_or_within positive regulation of stem cell proliferation 19700620 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16974 GO:0005515 IPI enables protein binding 12573468,15466886,16126904,16815997,17376403,18505367,18948618..... Function
16974 GO:0017147 IPI enables Wnt-protein binding 18606138 Function
16974 GO:0019534 IMP enables toxin transmembrane transporter activity 16564009 Function
16974 GO:0034185 IPI enables apolipoprotein binding 18948618 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
16974 GO:0005769 IDA located_in early endosome 18948618 Component
16974 GO:0005886 IDA located_in plasma membrane 18505367,18948618 Component
16974 GO:0016020 IDA located_in membrane 16126904 Component