Gene Ontology

Gene Info

• Species:Rat (Rattus norvegicus)
• GeneID:170922
• Symbol:Ilk
• Description:integrin-linked kinase

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170922	GO:0001558	IMP	involved_in	regulation of cell growth	16170337	Process
170922	GO:0001954	IMP	involved_in	positive regulation of cell-matrix adhesion	18535176	Process
170922	GO:0006468	IDA	involved_in	protein phosphorylation	14581460,18535176	Process
170922	GO:0006469	IMP	involved_in	negative regulation of protein kinase activity	12629168	Process
170922	GO:0007229	IMP	involved_in	integrin-mediated signaling pathway	12629168	Process
170922	GO:0008284	IMP	involved_in	positive regulation of cell population proliferation	16941698	Process
170922	GO:0010667	IMP	involved_in	negative regulation of cardiac muscle cell apoptotic process	16170337	Process
170922	GO:0014912	IMP	involved_in	negative regulation of smooth muscle cell migration	18535176	Process
170922	GO:0018105	IMP	involved_in	peptidyl-serine phosphorylation	14581460	Process
170922	GO:0030335	IMP	involved_in	positive regulation of cell migration	16941698	Process
170922	GO:0032288	IMP	involved_in	myelin assembly	14581460	Process
170922	GO:0032956	IMP	involved_in	regulation of actin cytoskeleton organization	17234816	Process
170922	GO:0034446	IMP	involved_in	substrate adhesion-dependent cell spreading	16941698	Process
170922	GO:0043066	IMP	involved_in	negative regulation of apoptotic process	16941698	Process
170922	GO:0043406	IMP	involved_in	positive regulation of MAP kinase activity	17182785	Process
170922	GO:0043410	IMP	involved_in	positive regulation of MAPK cascade	16941698	Process
170922	GO:0043524	IMP	involved_in	negative regulation of neuron apoptotic process	12629168	Process
170922	GO:0045663	IMP	involved_in	positive regulation of myoblast differentiation	14550274	Process
170922	GO:0045773	IMP	involved_in	positive regulation of axon extension	17490631	Process
170922	GO:0048662	IMP	involved_in	negative regulation of smooth muscle cell proliferation	18535176	Process
170922	GO:0048812	IMP	involved_in	neuron projection morphogenesis	12629168	Process
170922	GO:0050772	IMP	involved_in	positive regulation of axonogenesis	17490631	Process
170922	GO:0050775	IMP	involved_in	positive regulation of dendrite morphogenesis	17182785,18602949	Process
170922	GO:0051897	IMP	involved_in	positive regulation of protein kinase B signaling	16941698	Process
170922	GO:0097435	IMP	involved_in	supramolecular fiber organization	17234816,18535176	Process
170922	GO:2000774	IMP	involved_in	positive regulation of cellular senescence	17234816	Process

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170922	GO:0001725	IDA	colocalizes_with	stress fiber	18535176	Component
170922	GO:0005911	IDA	located_in	cell-cell junction	11133699	Component
170922	GO:0005925	IDA	located_in	focal adhesion	11304546,14581460,16170337,18535176	Component
170922	GO:0030424	IDA	located_in	axon	17490631	Component
170922	GO:0032991	IDA	part_of	protein-containing complex	16170337,17167118,17934340	Component
170922	GO:0043025	IDA	located_in	neuronal cell body	17490631	Component
170922	GO:0043034	IDA	located_in	costamere	16170337	Component
170922	GO:0043195	IDA	located_in	terminal bouton	17490631	Component
170922	GO:0043198	IDA	located_in	dendritic shaft	17490631	Component

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
170922	GO:0004672	IDA	enables	protein kinase activity	14581460,18535176	Function
170922	GO:0004674	IMP	enables	protein serine/threonine kinase activity	14581460	Function
170922	GO:0005178	IPI	enables	integrin binding	11133699	Function
170922	GO:0005515	IPI	enables	protein binding	14581460	Function
170922	GO:0017124	IDA	enables	SH3 domain binding	18252715	Function
170922	GO:0019904	IDA	enables	protein domain specific binding	11304546	Function
170922	GO:0044877	IDA	enables	protein-containing complex binding	17167118	Function
170922	GO:0044877	IPI	enables	protein-containing complex binding	16170337,17934340	Function