Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18039
  • Symbol:Nefl
  • Description:neurofilament, light polypeptide

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18039 GO:0000226 IMP acts_upstream_of_or_within microtubule cytoskeleton organization 11487626 Process
18039 GO:0007409 IMP acts_upstream_of axonogenesis 7946341 Process
18039 GO:0014012 IMP acts_upstream_of_or_within peripheral nervous system axon regeneration 9398473 Process
18039 GO:0031133 IMP acts_upstream_of_or_within regulation of axon diameter 9398473,11343650 Process
18039 GO:0040011 IMP acts_upstream_of_or_within locomotion 15132161 Process
18039 GO:0045109 IMP acts_upstream_of_or_within intermediate filament organization 2121744,7946341 Process
18039 GO:0045110 IGI acts_upstream_of_or_within intermediate filament bundle assembly 10461886 Process
18039 GO:0045110 IGI involved_in intermediate filament bundle assembly 11034913 Process
18039 GO:0048812 IMP acts_upstream_of_or_within neuron projection morphogenesis 10884316 Process
18039 GO:0050772 IMP acts_upstream_of_or_within positive regulation of axonogenesis 7946341 Process
18039 GO:0050885 IMP acts_upstream_of_or_within neuromuscular process controlling balance 15884021 Process
18039 GO:0060052 IGI acts_upstream_of_or_within neurofilament cytoskeleton organization 10350642,10461886,11343650 Process
18039 GO:0060052 IMP acts_upstream_of_or_within neurofilament cytoskeleton organization 9398473,11487626,14561875,15132161,16920084 Process
18039 GO:0090128 IDA involved_in regulation of synapse maturation 25232125 Process
18039 GO:0090128 IMP involved_in regulation of synapse maturation 25232125 Process
18039 GO:0097049 IMP acts_upstream_of motor neuron apoptotic process 7946341,10884316 Process
18039 GO:0099170 IDA involved_in postsynaptic modulation of chemical synaptic transmission 25869803 Process
18039 GO:0099170 IMP involved_in postsynaptic modulation of chemical synaptic transmission 25869803 Process
18039 GO:2000672 IMP acts_upstream_of_or_within negative regulation of motor neuron apoptotic process 7946341,10884316 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18039 GO:0005200 IDA enables structural constituent of cytoskeleton 11034913 Function
18039 GO:0005515 IPI enables protein binding 12403814,15208636,16236762,18687884 Function
18039 GO:0030674 IDA enables protein-macromolecule adaptor activity 11034913 Function
18039 GO:0099184 IDA enables structural constituent of postsynaptic intermediate filament cytoskeleton 25869803 Function
18039 GO:0099184 IMP enables structural constituent of postsynaptic intermediate filament cytoskeleton 25869803 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18039 GO:0005737 IDA located_in cytoplasm 11034913 Component
18039 GO:0005882 IDA located_in intermediate filament 2493000,11034913 Component
18039 GO:0005883 IDA located_in neurofilament 8821035,10221457,15242779 Component
18039 GO:0030424 IDA located_in axon 8110465,8821035 Component
18039 GO:0031594 IDA is_active_in neuromuscular junction 25232125 Component
18039 GO:0031594 IMP is_active_in neuromuscular junction 25232125 Component
18039 GO:0043005 IDA located_in neuron projection 11834298,19646951 Component
18039 GO:0043209 HDA located_in myelin sheath 17634366 Component
18039 GO:0098685 IDA is_active_in Schaffer collateral - CA1 synapse 25869803 Component
18039 GO:0098685 IMP is_active_in Schaffer collateral - CA1 synapse 25869803 Component
18039 GO:0098794 IDA located_in postsynapse 25869803 Component
18039 GO:0098981 IDA is_active_in cholinergic synapse 25232125 Component
18039 GO:0098981 IMP is_active_in cholinergic synapse 25232125 Component
18039 GO:0099160 IDA is_active_in postsynaptic intermediate filament cytoskeleton 25869803 Component
18039 GO:0099182 IDA is_active_in presynaptic intermediate filament cytoskeleton 25232125 Component