Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 18128
  • Symbol: Notch1
  • Description: notch 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18128 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 12032823 Process
18128 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 14701881,16025100,20890042 Process
18128 GO:0001701 IMP acts_upstream_of_or_within in utero embryonic development 7789282 Process
18128 GO:0001837 IMP acts_upstream_of_or_within epithelial to mesenchymal transition 14701881 Process
18128 GO:0001889 IMP acts_upstream_of_or_within liver development 15226394 Process
18128 GO:0001947 IGI involved_in heart looping 12730124 Process
18128 GO:0002040 IMP acts_upstream_of_or_within sprouting angiogenesis 15809373 Process
18128 GO:0002085 IMP acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation 15064243 Process
18128 GO:0002437 IGI acts_upstream_of_or_within inflammatory response to antigenic stimulus 17658279 Process
18128 GO:0003157 IMP involved_in endocardium development 17336907 Process
18128 GO:0003160 IEP involved_in endocardium morphogenesis 16025100 Process
18128 GO:0003160 IMP involved_in endocardium morphogenesis 20890042 Process
18128 GO:0003162 IMP involved_in atrioventricular node development 21266778 Process
18128 GO:0003169 IMP involved_in coronary vein morphogenesis 21311046 Process
18128 GO:0003180 IGI involved_in aortic valve morphogenesis 23583836,27107132 Process
18128 GO:0003180 IMP involved_in aortic valve morphogenesis 26491108 Process
18128 GO:0003181 IMP involved_in atrioventricular valve morphogenesis 14701881,21266778 Process
18128 GO:0003182 IMP involved_in coronary sinus valve morphogenesis 26491108 Process
18128 GO:0003184 IGI involved_in pulmonary valve morphogenesis 27107132 Process
18128 GO:0003184 IMP involved_in pulmonary valve morphogenesis 26491108 Process
18128 GO:0003197 IMP acts_upstream_of_or_within endocardial cushion development 14701881 Process
18128 GO:0003198 IMP involved_in epithelial to mesenchymal transition involved in endocardial cushion formation 14701881 Process
18128 GO:0003203 IGI involved_in endocardial cushion morphogenesis 27107132 Process
18128 GO:0003203 IMP involved_in endocardial cushion morphogenesis 14701881 Process
18128 GO:0003207 IMP involved_in cardiac chamber formation 20890042 Process
18128 GO:0003208 IMP involved_in cardiac ventricle morphogenesis 21311046 Process
18128 GO:0003209 IMP involved_in cardiac atrium morphogenesis 20890042 Process
18128 GO:0003213 IMP involved_in cardiac right atrium morphogenesis 20007915 Process
18128 GO:0003214 IMP involved_in cardiac left ventricle morphogenesis 20890042 Process
18128 GO:0003219 IMP acts_upstream_of_or_within cardiac right ventricle formation 19620969 Process
18128 GO:0003222 IMP involved_in ventricular trabecula myocardium morphogenesis 17336907 Process
18128 GO:0003241 IMP involved_in growth involved in heart morphogenesis 20007915 Process
18128 GO:0003252 IDA involved_in negative regulation of cell proliferation involved in heart valve morphogenesis 26491108 Process
18128 GO:0003252 IMP involved_in negative regulation of cell proliferation involved in heart valve morphogenesis 26491108 Process
18128 GO:0003270 IMP acts_upstream_of_or_within Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation 19620969 Process
18128 GO:0003273 IMP involved_in cell migration involved in endocardial cushion formation 20890042 Process
18128 GO:0003332 IMP involved_in negative regulation of extracellular matrix constituent secretion 26491108 Process
18128 GO:0003344 IMP involved_in pericardium morphogenesis 14701881,20890042,21311046 Process
18128 GO:0006357 IGI acts_upstream_of_or_within regulation of transcription by RNA polymerase II 15689374 Process
18128 GO:0006357 IMP acts_upstream_of_or_within regulation of transcription by RNA polymerase II 25535395 Process
18128 GO:0006357 IMP involved_in regulation of transcription by RNA polymerase II 20007915 Process
18128 GO:0006366 IDA acts_upstream_of transcription by RNA polymerase II 16618808,17658278 Process
18128 GO:0006366 IGI acts_upstream_of transcription by RNA polymerase II 16618808 Process
18128 GO:0006606 IDA involved_in protein import into nucleus 28561022 Process
18128 GO:0006915 IDA acts_upstream_of apoptotic process 15081359 Process
18128 GO:0006959 IGI acts_upstream_of_or_within humoral immune response 17658279 Process
18128 GO:0007219 IDA acts_upstream_of_or_within Notch signaling pathway 21419176 Process
18128 GO:0007219 IMP acts_upstream_of_or_within Notch signaling pathway 19154718 Process
18128 GO:0007221 IGI acts_upstream_of_or_within positive regulation of transcription of Notch receptor target 12794108,23160044 Process
18128 GO:0007368 IMP acts_upstream_of_or_within determination of left/right symmetry 7789282,12730124 Process
18128 GO:0007386 IMP acts_upstream_of_or_within compartment pattern specification 12001066 Process
18128 GO:0007409 IDA acts_upstream_of_or_within axonogenesis 15598981 Process
18128 GO:0007409 IMP acts_upstream_of_or_within axonogenesis 16120638 Process
18128 GO:0007440 IMP acts_upstream_of_or_within foregut morphogenesis 16107537 Process
18128 GO:0007492 IMP acts_upstream_of_or_within endoderm development 14657333 Process
18128 GO:0008283 IGI acts_upstream_of cell population proliferation 15509736 Process
18128 GO:0008544 IGI acts_upstream_of_or_within epidermis development 15525534 Process
18128 GO:0008593 IGI acts_upstream_of_or_within regulation of Notch signaling pathway 24667410 Process
18128 GO:0009912 IMP acts_upstream_of_or_within auditory receptor cell fate commitment 19154718 Process
18128 GO:0009957 IMP acts_upstream_of_or_within epidermal cell fate specification 15068794 Process
18128 GO:0010001 IMP acts_upstream_of_or_within glial cell differentiation 15965470 Process
18128 GO:0010467 IDA involved_in gene expression 28561022 Process
18128 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 9102301,11076679 Process
18128 GO:0010614 IMP involved_in negative regulation of cardiac muscle hypertrophy 26491108 Process
18128 GO:0010628 IGI involved_in positive regulation of gene expression 23583836 Process
18128 GO:0010718 IMP involved_in positive regulation of epithelial to mesenchymal transition 20890042 Process
18128 GO:0010832 IMP involved_in negative regulation of myotube differentiation 18299578 Process
18128 GO:0014031 IMP involved_in mesenchymal cell development 17303760 Process
18128 GO:0014807 IMP acts_upstream_of_or_within regulation of somitogenesis 7789282 Process
18128 GO:0017156 IMP acts_upstream_of calcium-ion regulated exocytosis 19251639 Process
18128 GO:0021915 IMP acts_upstream_of_or_within neural tube development 7789282 Process
18128 GO:0030154 IMP acts_upstream_of_or_within cell differentiation 14657333 Process
18128 GO:0030163 IDA involved_in protein catabolic process 28561022 Process
18128 GO:0030182 IGI acts_upstream_of neuron differentiation 10205173 Process
18128 GO:0030182 IMP acts_upstream_of neuron differentiation 16120638 Process
18128 GO:0030182 IMP acts_upstream_of_or_within neuron differentiation 9102301 Process
18128 GO:0030216 IGI acts_upstream_of keratinocyte differentiation 16618808 Process
18128 GO:0030216 IMP acts_upstream_of_or_within keratinocyte differentiation 15068794 Process
18128 GO:0030279 IMP involved_in negative regulation of ossification 21493891 Process
18128 GO:0030324 IMP acts_upstream_of_or_within lung development 15064243 Process
18128 GO:0030326 IGI acts_upstream_of_or_within embryonic limb morphogenesis 16169548 Process
18128 GO:0030334 IMP involved_in regulation of cell migration 20890042 Process
18128 GO:0030335 IMP involved_in positive regulation of cell migration 20890042 Process
18128 GO:0030513 IDA involved_in positive regulation of BMP signaling pathway 20547764 Process
18128 GO:0030514 IMP involved_in negative regulation of BMP signaling pathway 19695258 Process
18128 GO:0030900 IGI acts_upstream_of_or_within forebrain development 16120638 Process
18128 GO:0030900 IMP acts_upstream_of_or_within forebrain development 16120638 Process
18128 GO:0031069 IMP acts_upstream_of_or_within hair follicle morphogenesis 15525534,15978571 Process
18128 GO:0032495 IDA involved_in response to muramyl dipeptide 21156799 Process
18128 GO:0032633 IGI acts_upstream_of_or_within interleukin-4 production 17658279 Process
18128 GO:0035116 IMP acts_upstream_of_or_within embryonic hindlimb morphogenesis 16245338 Process
18128 GO:0035914 IMP acts_upstream_of_or_within skeletal muscle cell differentiation 22147266 Process
18128 GO:0042640 IMP acts_upstream_of_or_within anagen 15978571 Process
18128 GO:0042670 IMP acts_upstream_of retinal cone cell differentiation 16452096 Process
18128 GO:0043065 IDA acts_upstream_of_or_within positive regulation of apoptotic process 15081359 Process
18128 GO:0043065 IGI acts_upstream_of_or_within positive regulation of apoptotic process 16169548 Process
18128 GO:0043069 IMP acts_upstream_of_or_within negative regulation of programmed cell death 7789282 Process
18128 GO:0043086 IDA involved_in negative regulation of catalytic activity 17573339 Process
18128 GO:0045070 IMP involved_in positive regulation of viral genome replication 21191019 Process
18128 GO:0045607 IMP acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation 25535395 Process
18128 GO:0045608 IMP acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation 25535395 Process
18128 GO:0045618 IDA acts_upstream_of_or_within positive regulation of keratinocyte differentiation 17079689 Process
18128 GO:0045618 IGI acts_upstream_of_or_within positive regulation of keratinocyte differentiation 16618808 Process
18128 GO:0045665 IGI acts_upstream_of_or_within negative regulation of neuron differentiation 10205173 Process
18128 GO:0045665 IMP acts_upstream_of_or_within negative regulation of neuron differentiation 15064243,16120638 Process
18128 GO:0045668 IMP involved_in negative regulation of osteoblast differentiation 19695258 Process
18128 GO:0045747 IDA acts_upstream_of_or_within positive regulation of Notch signaling pathway 24667410 Process
18128 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 16025100 Process
18128 GO:0045892 IMP involved_in negative regulation of DNA-templated transcription 19695258 Process
18128 GO:0045893 IDA acts_upstream_of_or_within positive regulation of DNA-templated transcription 9111338 Process
18128 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 12666205,20547764 Process
18128 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 12783854,15902259,16145673,16618808,17658278 Process
18128 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 19245366,22110751 Process
18128 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 16618808 Process
18128 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 14701881,15107403,16025100,17303760,17336907,20007915,21311046..... Process
18128 GO:0045955 IMP acts_upstream_of_or_within negative regulation of calcium ion-dependent exocytosis 19251639 Process
18128 GO:0046427 IDA involved_in positive regulation of receptor signaling pathway via JAK-STAT 15156153 Process
18128 GO:0046533 IMP acts_upstream_of_or_within negative regulation of photoreceptor cell differentiation 16452096 Process
18128 GO:0048103 IDA acts_upstream_of_or_within somatic stem cell division 12717450 Process
18128 GO:0048103 IGI acts_upstream_of_or_within somatic stem cell division 15509736 Process
18128 GO:0048663 IGI acts_upstream_of_or_within neuron fate commitment 16120638 Process
18128 GO:0048709 IMP acts_upstream_of_or_within oligodendrocyte differentiation 12186854 Process
18128 GO:0048711 IDA involved_in positive regulation of astrocyte differentiation 12666205 Process
18128 GO:0048715 IDA involved_in negative regulation of oligodendrocyte differentiation 12666205 Process
18128 GO:0048754 IMP acts_upstream_of_or_within branching morphogenesis of an epithelial tube 15064243 Process
18128 GO:0048845 IMP acts_upstream_of_or_within venous blood vessel morphogenesis 18952909 Process
18128 GO:0048873 IGI involved_in homeostasis of number of cells within a tissue 27107132 Process
18128 GO:0050434 IMP involved_in positive regulation of viral transcription 21191019 Process
18128 GO:0050673 IGI acts_upstream_of epithelial cell proliferation 15509736,19251639 Process
18128 GO:0050673 IMP acts_upstream_of epithelial cell proliferation 25535395 Process
18128 GO:0050678 IGI acts_upstream_of_or_within regulation of epithelial cell proliferation 25535395 Process
18128 GO:0050678 IMP acts_upstream_of_or_within regulation of epithelial cell proliferation 16107537 Process
18128 GO:0050679 IGI acts_upstream_of_or_within positive regulation of epithelial cell proliferation 15509736,19251639 Process
18128 GO:0050680 IMP acts_upstream_of_or_within negative regulation of epithelial cell proliferation 25535395 Process
18128 GO:0050767 IMP acts_upstream_of_or_within regulation of neurogenesis 9102301 Process
18128 GO:0050768 IMP involved_in negative regulation of neurogenesis 18299578 Process
18128 GO:0055008 IMP involved_in cardiac muscle tissue morphogenesis 20007915 Process
18128 GO:0060038 IMP involved_in cardiac muscle cell proliferation 21311046 Process
18128 GO:0060045 IMP involved_in positive regulation of cardiac muscle cell proliferation 20007915 Process
18128 GO:0060253 IDA involved_in negative regulation of glial cell proliferation 12666205 Process
18128 GO:0060317 IMP involved_in cardiac epithelial to mesenchymal transition 17303760 Process
18128 GO:0060379 IMP involved_in cardiac muscle cell myoblast differentiation 20007915 Process
18128 GO:0060411 IMP involved_in cardiac septum morphogenesis 20007915 Process
18128 GO:0060412 IGI involved_in ventricular septum morphogenesis 27107132 Process
18128 GO:0060412 IMP involved_in ventricular septum morphogenesis 26491108 Process
18128 GO:0060528 IMP acts_upstream_of_or_within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development 16360140 Process
18128 GO:0060740 IMP acts_upstream_of_or_within prostate gland epithelium morphogenesis 16360140 Process
18128 GO:0060768 IMP acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development 16360140 Process
18128 GO:0060842 IMP involved_in arterial endothelial cell differentiation 15107403 Process
18128 GO:0060843 IMP involved_in venous endothelial cell differentiation 20890042 Process
18128 GO:0060948 IMP involved_in cardiac vascular smooth muscle cell development 21311046 Process
18128 GO:0060956 IMP involved_in endocardial cell differentiation 20890042 Process
18128 GO:0060979 IMP involved_in vasculogenesis involved in coronary vascular morphogenesis 21311046 Process
18128 GO:0060982 IMP involved_in coronary artery morphogenesis 21311046 Process
18128 GO:0061101 IMP acts_upstream_of neuroendocrine cell differentiation 15064243 Process
18128 GO:0061314 IGI involved_in Notch signaling involved in heart development 20890042 Process
18128 GO:0061314 IMP involved_in Notch signaling involved in heart development 14701881,20007915 Process
18128 GO:0061384 IMP involved_in heart trabecula morphogenesis 20890042 Process
18128 GO:0070168 IDA involved_in negative regulation of biomineral tissue development 23583836 Process
18128 GO:0070168 IMP involved_in negative regulation of biomineral tissue development 26491108 Process
18128 GO:0070986 IGI involved_in left/right axis specification 12730124 Process
18128 GO:0071456 IDA involved_in cellular response to hypoxia 18299578 Process
18128 GO:0072017 IEP involved_in distal tubule development 15821257 Process
18128 GO:0072044 IEP involved_in collecting duct development 15821257 Process
18128 GO:0072091 IMP acts_upstream_of_or_within regulation of stem cell proliferation 16107537 Process
18128 GO:0072144 IEP involved_in glomerular mesangial cell development 15821257 Process
18128 GO:0072148 IMP acts_upstream_of_or_within epithelial cell fate commitment 16107537 Process
18128 GO:0072538 IDA involved_in T-helper 17 type immune response 28561022 Process
18128 GO:0090090 IMP acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway 19620969,25535395 Process
18128 GO:0097400 IDA involved_in interleukin-17-mediated signaling pathway 28561022 Process
18128 GO:0120163 IMP involved_in negative regulation of cold-induced thermogenesis 25038826 Process
18128 GO:1901201 IMP involved_in regulation of extracellular matrix assembly 21311046 Process
18128 GO:1902263 IMP acts_upstream_of_or_within apoptotic process involved in embryonic digit morphogenesis 16245338 Process
18128 GO:1902339 IDA involved_in positive regulation of apoptotic process involved in morphogenesis 26491108 Process
18128 GO:1903849 IMP acts_upstream_of_or_within positive regulation of aorta morphogenesis 18952909 Process
18128 GO:2000974 IMP involved_in negative regulation of pro-B cell differentiation 12032823 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18128 GO:0003682 IDA enables chromatin binding 15689374 Function
18128 GO:0003713 IDA enables transcription coactivator activity 9111338,17336907,17658278 Function
18128 GO:0004857 IDA enables enzyme inhibitor activity 17573339 Function
18128 GO:0005112 IPI enables Notch binding 24667410 Function
18128 GO:0005515 IPI enables protein binding 8749394,9315665,10551863,10958687,12050162,15574878,17210915,1..... Function
18128 GO:0019899 IPI enables enzyme binding 17573339,18299578 Function
18128 GO:0031490 IDA enables chromatin DNA binding 17658278 Function
18128 GO:0140537 IDA enables transcription regulator activator activity 18299578 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18128 GO:0005634 IDA located_in nucleus 10206645,16324690,16607638,17079689,17336907,17685488,18299578..... Component
18128 GO:0005634 IMP located_in nucleus 20007915 Component
18128 GO:0005737 IDA located_in cytoplasm 15965470 Component
18128 GO:0005783 IDA located_in endoplasmic reticulum 24667410 Component
18128 GO:0005886 IDA located_in plasma membrane 17079689,24667410,26491108 Component
18128 GO:0005912 IDA located_in adherens junction 24715457 Component
18128 GO:0009986 IDA located_in cell surface 15574878 Component
18128 GO:0016324 IDA located_in apical plasma membrane 24715457 Component
18128 GO:0031410 IDA located_in cytoplasmic vesicle 24667410 Component
18128 GO:0071944 IDA located_in cell periphery 23284756 Component