Gene Ontology

Gene Info

• Species:Mouse (Mus musculus)
• GeneID:18128
• Symbol:Notch1
• Description:notch 1

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
18128	GO:0000122	IDA	involved_in	negative regulation of transcription by RNA polymerase II	12032823	Process
18128	GO:0000122	IMP	involved_in	negative regulation of transcription by RNA polymerase II	14701881,16025100,20890042	Process
18128	GO:0001701	IMP	acts_upstream_of_or_within	in utero embryonic development	7789282	Process
18128	GO:0001837	IMP	acts_upstream_of_or_within	epithelial to mesenchymal transition	14701881	Process
18128	GO:0001889	IMP	acts_upstream_of_or_within	liver development	15226394	Process
18128	GO:0001947	IGI	involved_in	heart looping	12730124	Process
18128	GO:0002040	IMP	acts_upstream_of_or_within	sprouting angiogenesis	15809373	Process
18128	GO:0002085	IMP	acts_upstream_of_or_within	inhibition of neuroepithelial cell differentiation	15064243	Process
18128	GO:0002437	IGI	acts_upstream_of_or_within	inflammatory response to antigenic stimulus	17658279	Process
18128	GO:0003157	IMP	involved_in	endocardium development	17336907	Process
18128	GO:0003160	IEP	involved_in	endocardium morphogenesis	16025100	Process
18128	GO:0003160	IMP	involved_in	endocardium morphogenesis	20890042	Process
18128	GO:0003162	IMP	involved_in	atrioventricular node development	21266778	Process
18128	GO:0003169	IMP	involved_in	coronary vein morphogenesis	21311046	Process
18128	GO:0003180	IGI	involved_in	aortic valve morphogenesis	23583836,27107132	Process
18128	GO:0003180	IMP	involved_in	aortic valve morphogenesis	26491108	Process
18128	GO:0003181	IMP	involved_in	atrioventricular valve morphogenesis	14701881,21266778	Process
18128	GO:0003182	IMP	involved_in	coronary sinus valve morphogenesis	26491108	Process
18128	GO:0003184	IGI	involved_in	pulmonary valve morphogenesis	27107132	Process
18128	GO:0003184	IMP	involved_in	pulmonary valve morphogenesis	26491108	Process
18128	GO:0003197	IMP	acts_upstream_of_or_within	endocardial cushion development	14701881	Process
18128	GO:0003198	IMP	involved_in	epithelial to mesenchymal transition involved in endocardial cushion formation	14701881	Process
18128	GO:0003203	IGI	involved_in	endocardial cushion morphogenesis	27107132	Process
18128	GO:0003203	IMP	involved_in	endocardial cushion morphogenesis	14701881	Process
18128	GO:0003207	IMP	involved_in	cardiac chamber formation	20890042	Process
18128	GO:0003208	IMP	involved_in	cardiac ventricle morphogenesis	21311046	Process
18128	GO:0003209	IMP	involved_in	cardiac atrium morphogenesis	20890042	Process
18128	GO:0003213	IMP	involved_in	cardiac right atrium morphogenesis	20007915	Process
18128	GO:0003214	IMP	involved_in	cardiac left ventricle morphogenesis	20890042	Process
18128	GO:0003219	IMP	acts_upstream_of_or_within	cardiac right ventricle formation	19620969	Process
18128	GO:0003222	IMP	involved_in	ventricular trabecula myocardium morphogenesis	17336907	Process
18128	GO:0003241	IMP	involved_in	growth involved in heart morphogenesis	20007915	Process
18128	GO:0003252	IDA	involved_in	negative regulation of cell proliferation involved in heart valve morphogenesis	26491108	Process
18128	GO:0003252	IMP	involved_in	negative regulation of cell proliferation involved in heart valve morphogenesis	26491108	Process
18128	GO:0003270	IMP	acts_upstream_of_or_within	Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation	19620969	Process
18128	GO:0003273	IMP	involved_in	cell migration involved in endocardial cushion formation	20890042	Process
18128	GO:0003332	IMP	involved_in	negative regulation of extracellular matrix constituent secretion	26491108	Process
18128	GO:0003344	IMP	involved_in	pericardium morphogenesis	14701881,20890042,21311046	Process
18128	GO:0006357	IGI	acts_upstream_of_or_within	regulation of transcription by RNA polymerase II	15689374	Process
18128	GO:0006357	IMP	acts_upstream_of_or_within	regulation of transcription by RNA polymerase II	25535395	Process
18128	GO:0006357	IMP	involved_in	regulation of transcription by RNA polymerase II	20007915	Process
18128	GO:0006366	IDA	acts_upstream_of	transcription by RNA polymerase II	16618808,17658278	Process
18128	GO:0006366	IGI	acts_upstream_of	transcription by RNA polymerase II	16618808	Process
18128	GO:0006606	IDA	involved_in	protein import into nucleus	28561022	Process
18128	GO:0006915	IDA	acts_upstream_of	apoptotic process	15081359	Process
18128	GO:0006959	IGI	acts_upstream_of_or_within	humoral immune response	17658279	Process
18128	GO:0007219	IDA	acts_upstream_of_or_within	Notch signaling pathway	21419176	Process
18128	GO:0007219	IMP	acts_upstream_of_or_within	Notch signaling pathway	19154718	Process
18128	GO:0007221	IGI	acts_upstream_of_or_within	positive regulation of transcription of Notch receptor target	12794108,23160044	Process
18128	GO:0007368	IMP	acts_upstream_of_or_within	determination of left/right symmetry	7789282,12730124	Process
18128	GO:0007386	IMP	acts_upstream_of_or_within	compartment pattern specification	12001066	Process
18128	GO:0007409	IDA	acts_upstream_of_or_within	axonogenesis	15598981	Process
18128	GO:0007409	IMP	acts_upstream_of_or_within	axonogenesis	16120638	Process
18128	GO:0007440	IMP	acts_upstream_of_or_within	foregut morphogenesis	16107537	Process
18128	GO:0007492	IMP	acts_upstream_of_or_within	endoderm development	14657333	Process
18128	GO:0008283	IGI	acts_upstream_of	cell population proliferation	15509736	Process
18128	GO:0008544	IGI	acts_upstream_of_or_within	epidermis development	15525534	Process
18128	GO:0008593	IGI	acts_upstream_of_or_within	regulation of Notch signaling pathway	24667410	Process
18128	GO:0009912	IMP	acts_upstream_of_or_within	auditory receptor cell fate commitment	19154718	Process
18128	GO:0009957	IMP	acts_upstream_of_or_within	epidermal cell fate specification	15068794	Process
18128	GO:0010001	IMP	acts_upstream_of_or_within	glial cell differentiation	15965470	Process
18128	GO:0010467	IDA	involved_in	gene expression	28561022	Process
18128	GO:0010468	IMP	acts_upstream_of_or_within	regulation of gene expression	9102301,11076679	Process
18128	GO:0010614	IMP	involved_in	negative regulation of cardiac muscle hypertrophy	26491108	Process
18128	GO:0010628	IGI	involved_in	positive regulation of gene expression	23583836	Process
18128	GO:0010718	IMP	involved_in	positive regulation of epithelial to mesenchymal transition	20890042	Process
18128	GO:0010832	IMP	involved_in	negative regulation of myotube differentiation	18299578	Process
18128	GO:0014031	IMP	involved_in	mesenchymal cell development	17303760	Process
18128	GO:0014807	IMP	acts_upstream_of_or_within	regulation of somitogenesis	7789282	Process
18128	GO:0017156	IMP	acts_upstream_of	calcium-ion regulated exocytosis	19251639	Process
18128	GO:0021915	IMP	acts_upstream_of_or_within	neural tube development	7789282	Process
18128	GO:0030154	IMP	acts_upstream_of_or_within	cell differentiation	14657333	Process
18128	GO:0030163	IDA	involved_in	protein catabolic process	28561022	Process
18128	GO:0030182	IGI	acts_upstream_of	neuron differentiation	10205173	Process
18128	GO:0030182	IMP	acts_upstream_of	neuron differentiation	16120638	Process
18128	GO:0030182	IMP	acts_upstream_of_or_within	neuron differentiation	9102301	Process
18128	GO:0030216	IGI	acts_upstream_of	keratinocyte differentiation	16618808	Process
18128	GO:0030216	IMP	acts_upstream_of_or_within	keratinocyte differentiation	15068794	Process
18128	GO:0030279	IMP	involved_in	negative regulation of ossification	21493891	Process
18128	GO:0030324	IMP	acts_upstream_of_or_within	lung development	15064243	Process
18128	GO:0030326	IGI	acts_upstream_of_or_within	embryonic limb morphogenesis	16169548	Process
18128	GO:0030334	IMP	involved_in	regulation of cell migration	20890042	Process
18128	GO:0030335	IMP	involved_in	positive regulation of cell migration	20890042	Process
18128	GO:0030513	IDA	involved_in	positive regulation of BMP signaling pathway	20547764	Process
18128	GO:0030514	IMP	involved_in	negative regulation of BMP signaling pathway	19695258	Process
18128	GO:0030900	IGI	acts_upstream_of_or_within	forebrain development	16120638	Process
18128	GO:0030900	IMP	acts_upstream_of_or_within	forebrain development	16120638	Process
18128	GO:0031069	IMP	acts_upstream_of_or_within	hair follicle morphogenesis	15525534,15978571	Process
18128	GO:0032495	IDA	involved_in	response to muramyl dipeptide	21156799	Process
18128	GO:0032633	IGI	acts_upstream_of_or_within	interleukin-4 production	17658279	Process
18128	GO:0035116	IMP	acts_upstream_of_or_within	embryonic hindlimb morphogenesis	16245338	Process
18128	GO:0035914	IMP	acts_upstream_of_or_within	skeletal muscle cell differentiation	22147266	Process
18128	GO:0042640	IMP	acts_upstream_of_or_within	anagen	15978571	Process
18128	GO:0042670	IMP	acts_upstream_of	retinal cone cell differentiation	16452096	Process
18128	GO:0043065	IDA	acts_upstream_of_or_within	positive regulation of apoptotic process	15081359	Process
18128	GO:0043065	IGI	acts_upstream_of_or_within	positive regulation of apoptotic process	16169548	Process
18128	GO:0043069	IMP	acts_upstream_of_or_within	negative regulation of programmed cell death	7789282	Process
18128	GO:0043086	IDA	involved_in	negative regulation of catalytic activity	17573339	Process
18128	GO:0045070	IMP	involved_in	positive regulation of viral genome replication	21191019	Process
18128	GO:0045607	IMP	acts_upstream_of_or_within	regulation of inner ear auditory receptor cell differentiation	25535395	Process
18128	GO:0045608	IMP	acts_upstream_of_or_within	negative regulation of inner ear auditory receptor cell differentiation	25535395	Process
18128	GO:0045618	IDA	acts_upstream_of_or_within	positive regulation of keratinocyte differentiation	17079689	Process
18128	GO:0045618	IGI	acts_upstream_of_or_within	positive regulation of keratinocyte differentiation	16618808	Process
18128	GO:0045665	IGI	acts_upstream_of_or_within	negative regulation of neuron differentiation	10205173	Process
18128	GO:0045665	IMP	acts_upstream_of_or_within	negative regulation of neuron differentiation	15064243,16120638	Process
18128	GO:0045668	IMP	involved_in	negative regulation of osteoblast differentiation	19695258	Process
18128	GO:0045747	IDA	acts_upstream_of_or_within	positive regulation of Notch signaling pathway	24667410	Process
18128	GO:0045892	IDA	involved_in	negative regulation of DNA-templated transcription	16025100	Process
18128	GO:0045892	IMP	involved_in	negative regulation of DNA-templated transcription	19695258	Process
18128	GO:0045893	IDA	acts_upstream_of_or_within	positive regulation of DNA-templated transcription	9111338	Process
18128	GO:0045893	IDA	involved_in	positive regulation of DNA-templated transcription	12666205,20547764	Process
18128	GO:0045944	IDA	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	12783854,15902259,16145673,16618808,17658278	Process
18128	GO:0045944	IDA	involved_in	positive regulation of transcription by RNA polymerase II	19245366,22110751	Process
18128	GO:0045944	IGI	acts_upstream_of_or_within	positive regulation of transcription by RNA polymerase II	16618808	Process
18128	GO:0045944	IMP	involved_in	positive regulation of transcription by RNA polymerase II	14701881,15107403,16025100,17303760,17336907,20007915,21311046.....	Process
18128	GO:0045955	IMP	acts_upstream_of_or_within	negative regulation of calcium ion-dependent exocytosis	19251639	Process
18128	GO:0046427	IDA	involved_in	positive regulation of receptor signaling pathway via JAK-STAT	15156153	Process
18128	GO:0046533	IMP	acts_upstream_of_or_within	negative regulation of photoreceptor cell differentiation	16452096	Process
18128	GO:0048103	IDA	acts_upstream_of_or_within	somatic stem cell division	12717450	Process
18128	GO:0048103	IGI	acts_upstream_of_or_within	somatic stem cell division	15509736	Process
18128	GO:0048663	IGI	acts_upstream_of_or_within	neuron fate commitment	16120638	Process
18128	GO:0048709	IMP	acts_upstream_of_or_within	oligodendrocyte differentiation	12186854	Process
18128	GO:0048711	IDA	involved_in	positive regulation of astrocyte differentiation	12666205	Process
18128	GO:0048715	IDA	involved_in	negative regulation of oligodendrocyte differentiation	12666205	Process
18128	GO:0048754	IMP	acts_upstream_of_or_within	branching morphogenesis of an epithelial tube	15064243	Process
18128	GO:0048845	IMP	acts_upstream_of_or_within	venous blood vessel morphogenesis	18952909	Process
18128	GO:0048873	IGI	involved_in	homeostasis of number of cells within a tissue	27107132	Process
18128	GO:0050434	IMP	involved_in	positive regulation of viral transcription	21191019	Process
18128	GO:0050673	IGI	acts_upstream_of	epithelial cell proliferation	15509736,19251639	Process
18128	GO:0050673	IMP	acts_upstream_of	epithelial cell proliferation	25535395	Process
18128	GO:0050678	IGI	acts_upstream_of_or_within	regulation of epithelial cell proliferation	25535395	Process
18128	GO:0050678	IMP	acts_upstream_of_or_within	regulation of epithelial cell proliferation	16107537	Process
18128	GO:0050679	IGI	acts_upstream_of_or_within	positive regulation of epithelial cell proliferation	15509736,19251639	Process
18128	GO:0050680	IMP	acts_upstream_of_or_within	negative regulation of epithelial cell proliferation	25535395	Process
18128	GO:0050767	IMP	acts_upstream_of_or_within	regulation of neurogenesis	9102301	Process
18128	GO:0050768	IMP	involved_in	negative regulation of neurogenesis	18299578	Process
18128	GO:0055008	IMP	involved_in	cardiac muscle tissue morphogenesis	20007915	Process
18128	GO:0060038	IMP	involved_in	cardiac muscle cell proliferation	21311046	Process
18128	GO:0060045	IMP	involved_in	positive regulation of cardiac muscle cell proliferation	20007915	Process
18128	GO:0060253	IDA	involved_in	negative regulation of glial cell proliferation	12666205	Process
18128	GO:0060317	IMP	involved_in	cardiac epithelial to mesenchymal transition	17303760	Process
18128	GO:0060379	IMP	involved_in	cardiac muscle cell myoblast differentiation	20007915	Process
18128	GO:0060411	IMP	involved_in	cardiac septum morphogenesis	20007915	Process
18128	GO:0060412	IGI	involved_in	ventricular septum morphogenesis	27107132	Process
18128	GO:0060412	IMP	involved_in	ventricular septum morphogenesis	26491108	Process
18128	GO:0060528	IMP	acts_upstream_of_or_within	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	16360140	Process
18128	GO:0060740	IMP	acts_upstream_of_or_within	prostate gland epithelium morphogenesis	16360140	Process
18128	GO:0060768	IMP	acts_upstream_of_or_within	regulation of epithelial cell proliferation involved in prostate gland development	16360140	Process
18128	GO:0060842	IMP	involved_in	arterial endothelial cell differentiation	15107403	Process
18128	GO:0060843	IMP	involved_in	venous endothelial cell differentiation	20890042	Process
18128	GO:0060948	IMP	involved_in	cardiac vascular smooth muscle cell development	21311046	Process
18128	GO:0060956	IMP	involved_in	endocardial cell differentiation	20890042	Process
18128	GO:0060979	IMP	involved_in	vasculogenesis involved in coronary vascular morphogenesis	21311046	Process
18128	GO:0060982	IMP	involved_in	coronary artery morphogenesis	21311046	Process
18128	GO:0061101	IMP	acts_upstream_of	neuroendocrine cell differentiation	15064243	Process
18128	GO:0061314	IGI	involved_in	Notch signaling involved in heart development	20890042	Process
18128	GO:0061314	IMP	involved_in	Notch signaling involved in heart development	14701881,20007915	Process
18128	GO:0061384	IMP	involved_in	heart trabecula morphogenesis	20890042	Process
18128	GO:0070168	IDA	involved_in	negative regulation of biomineral tissue development	23583836	Process
18128	GO:0070168	IMP	involved_in	negative regulation of biomineral tissue development	26491108	Process
18128	GO:0070986	IGI	involved_in	left/right axis specification	12730124	Process
18128	GO:0071456	IDA	involved_in	cellular response to hypoxia	18299578	Process
18128	GO:0072017	IEP	involved_in	distal tubule development	15821257	Process
18128	GO:0072044	IEP	involved_in	collecting duct development	15821257	Process
18128	GO:0072091	IMP	acts_upstream_of_or_within	regulation of stem cell proliferation	16107537	Process
18128	GO:0072144	IEP	involved_in	glomerular mesangial cell development	15821257	Process
18128	GO:0072148	IMP	acts_upstream_of_or_within	epithelial cell fate commitment	16107537	Process
18128	GO:0072538	IDA	involved_in	T-helper 17 type immune response	28561022	Process
18128	GO:0090090	IMP	acts_upstream_of_or_within	negative regulation of canonical Wnt signaling pathway	19620969,25535395	Process
18128	GO:0097400	IDA	involved_in	interleukin-17-mediated signaling pathway	28561022	Process
18128	GO:0120163	IMP	involved_in	negative regulation of cold-induced thermogenesis	25038826	Process
18128	GO:1901201	IMP	involved_in	regulation of extracellular matrix assembly	21311046	Process
18128	GO:1902263	IMP	acts_upstream_of_or_within	apoptotic process involved in embryonic digit morphogenesis	16245338	Process
18128	GO:1902339	IDA	involved_in	positive regulation of apoptotic process involved in morphogenesis	26491108	Process
18128	GO:1903849	IMP	acts_upstream_of_or_within	positive regulation of aorta morphogenesis	18952909	Process
18128	GO:2000974	IMP	involved_in	negative regulation of pro-B cell differentiation	12032823	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
18128	GO:0003682	IDA	enables	chromatin binding	15689374	Function
18128	GO:0003713	IDA	enables	transcription coactivator activity	9111338,17336907,17658278	Function
18128	GO:0004857	IDA	enables	enzyme inhibitor activity	17573339	Function
18128	GO:0005112	IPI	enables	Notch binding	24667410	Function
18128	GO:0005515	IPI	enables	protein binding	8749394,9315665,10551863,10958687,12050162,15574878,17210915,1.....	Function
18128	GO:0019899	IPI	enables	enzyme binding	17573339,18299578	Function
18128	GO:0031490	IDA	enables	chromatin DNA binding	17658278	Function
18128	GO:0140537	IDA	enables	transcription regulator activator activity	18299578	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
18128	GO:0005634	IDA	located_in	nucleus	10206645,16324690,16607638,17079689,17336907,17685488,18299578.....	Component
18128	GO:0005634	IMP	located_in	nucleus	20007915	Component
18128	GO:0005737	IDA	located_in	cytoplasm	15965470	Component
18128	GO:0005783	IDA	located_in	endoplasmic reticulum	24667410	Component
18128	GO:0005886	IDA	located_in	plasma membrane	17079689,24667410,26491108	Component
18128	GO:0005912	IDA	located_in	adherens junction	24715457	Component
18128	GO:0009986	IDA	located_in	cell surface	15574878	Component
18128	GO:0016324	IDA	located_in	apical plasma membrane	24715457	Component
18128	GO:0031410	IDA	located_in	cytoplasmic vesicle	24667410	Component
18128	GO:0071944	IDA	located_in	cell periphery	23284756	Component