Gene Ontology

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 18508
  • Symbol: Pax6
  • Description: paired box 6

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18508 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 23990468 Process
18508 GO:0000132 IMP acts_upstream_of_or_within establishment of mitotic spindle orientation 22031545 Process
18508 GO:0001709 IMP acts_upstream_of_or_within cell fate determination 12756174 Process
18508 GO:0001764 IMP acts_upstream_of_or_within neuron migration 15758185 Process
18508 GO:0001764 IMP involved_in neuron migration 30186101 Process
18508 GO:0001933 IMP acts_upstream_of_or_within negative regulation of protein phosphorylation 16497297 Process
18508 GO:0002052 IMP acts_upstream_of_or_within positive regulation of neuroblast proliferation 18287938 Process
18508 GO:0002067 IMP acts_upstream_of glandular epithelial cell differentiation 16080917 Process
18508 GO:0002088 IMP acts_upstream_of_or_within lens development in camera-type eye 6877261 Process
18508 GO:0003002 IMP acts_upstream_of_or_within regionalization 9169845,24528677 Process
18508 GO:0003309 IMP acts_upstream_of_or_within type B pancreatic cell differentiation 22764048 Process
18508 GO:0003322 IMP involved_in pancreatic A cell development 20592023 Process
18508 GO:0006306 IMP involved_in DNA methylation 30186101 Process
18508 GO:0006338 IMP involved_in chromatin remodeling 30186101 Process
18508 GO:0006357 IMP acts_upstream_of_or_within regulation of transcription by RNA polymerase II 9230312,19521500 Process
18508 GO:0006366 IGI acts_upstream_of transcription by RNA polymerase II 23643363 Process
18508 GO:0006468 IMP acts_upstream_of protein phosphorylation 16497297 Process
18508 GO:0007224 IDA acts_upstream_of_or_within smoothened signaling pathway 18590716 Process
18508 GO:0007405 IMP acts_upstream_of neuroblast proliferation 15548580,18287938 Process
18508 GO:0007406 IMP acts_upstream_of_or_within negative regulation of neuroblast proliferation 15548580 Process
18508 GO:0007409 IMP acts_upstream_of_or_within axonogenesis 15514979 Process
18508 GO:0007411 IMP acts_upstream_of_or_within axon guidance 11967891,14586016 Process
18508 GO:0007420 IMP acts_upstream_of_or_within brain development 10409504,12196586 Process
18508 GO:0007435 IMP acts_upstream_of_or_within salivary gland morphogenesis 11731698 Process
18508 GO:0008283 IMP acts_upstream_of cell population proliferation 15548580 Process
18508 GO:0009786 IMP acts_upstream_of_or_within regulation of asymmetric cell division 22031545 Process
18508 GO:0009950 IMP acts_upstream_of_or_within dorsal/ventral axis specification 10588713 Process
18508 GO:0009952 IGI acts_upstream_of_or_within anterior/posterior pattern specification 15917450 Process
18508 GO:0009952 IMP acts_upstream_of_or_within anterior/posterior pattern specification 12196586 Process
18508 GO:0009953 IMP acts_upstream_of_or_within dorsal/ventral pattern formation 15548580,15878992 Process
18508 GO:0010467 IMP acts_upstream_of_or_within gene expression 24488179 Process
18508 GO:0010467 IMP involved_in gene expression 30186101 Process
18508 GO:0010468 IMP acts_upstream_of_or_within regulation of gene expression 12764040,16919471,18799682 Process
18508 GO:0010628 IMP involved_in positive regulation of gene expression 20592023 Process
18508 GO:0021517 IMP involved_in ventral spinal cord development 20844123 Process
18508 GO:0021543 IMP acts_upstream_of_or_within pallium development 11124115 Process
18508 GO:0021778 IMP acts_upstream_of_or_within oligodendrocyte cell fate specification 9828088 Process
18508 GO:0021796 IMP acts_upstream_of_or_within cerebral cortex regionalization 12764040,23431145 Process
18508 GO:0021796 IMP involved_in cerebral cortex regionalization 30186101 Process
18508 GO:0021798 IMP acts_upstream_of_or_within forebrain dorsal/ventral pattern formation 11050125,11124115,18701439,24528677 Process
18508 GO:0021902 IMP acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain 11124115 Process
18508 GO:0021905 IMP acts_upstream_of_or_within forebrain-midbrain boundary formation 9169845 Process
18508 GO:0021978 IMP acts_upstream_of_or_within telencephalon regionalization 18701439 Process
18508 GO:0021983 IMP acts_upstream_of_or_within pituitary gland development 10588713 Process
18508 GO:0021986 IMP acts_upstream_of_or_within habenula development 24528677 Process
18508 GO:0021987 IMP involved_in cerebral cortex development 30186101 Process
18508 GO:0023019 IDA acts_upstream_of_or_within signal transduction involved in regulation of gene expression 18462699 Process
18508 GO:0030154 IMP acts_upstream_of_or_within cell differentiation 15031110,24528677 Process
18508 GO:0030182 IGI acts_upstream_of neuron differentiation 16950124 Process
18508 GO:0030182 IMP involved_in neuron differentiation 30186101 Process
18508 GO:0030216 IMP acts_upstream_of_or_within keratinocyte differentiation 16080917 Process
18508 GO:0030334 IMP acts_upstream_of_or_within regulation of cell migration 10409504,18701439 Process
18508 GO:0030858 IMP acts_upstream_of_or_within positive regulation of epithelial cell differentiation 16080917 Process
18508 GO:0030900 IMP acts_upstream_of_or_within forebrain development 15514979,15548580,15758185 Process
18508 GO:0032808 IMP acts_upstream_of_or_within lacrimal gland development 10821755 Process
18508 GO:0033365 IMP acts_upstream_of_or_within protein localization to organelle 16024294 Process
18508 GO:0042462 IMP acts_upstream_of_or_within eye photoreceptor cell development 12648492 Process
18508 GO:0043010 IGI acts_upstream_of_or_within camera-type eye development 12072567,12183364 Process
18508 GO:0043010 IMP acts_upstream_of_or_within camera-type eye development 11062307,11069887,12648492,12756174,16080917 Process
18508 GO:0045165 IGI acts_upstream_of_or_within cell fate commitment 15229646 Process
18508 GO:0045165 IMP acts_upstream_of_or_within cell fate commitment 15878992 Process
18508 GO:0045664 IMP acts_upstream_of_or_within regulation of neuron differentiation 15548580 Process
18508 GO:0045665 IGI acts_upstream_of_or_within negative regulation of neuron differentiation 16950124 Process
18508 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 20592023 Process
18508 GO:0045944 IDA acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 15905411,18287938,19749747 Process
18508 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 12756174,16407227 Process
18508 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 19146846,23643363 Process
18508 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 20592023 Process
18508 GO:0048505 IMP acts_upstream_of_or_within regulation of timing of cell differentiation 9828088 Process
18508 GO:0048596 IGI acts_upstream_of_or_within embryonic camera-type eye morphogenesis 18653562 Process
18508 GO:0048708 IMP acts_upstream_of_or_within astrocyte differentiation 19258013 Process
18508 GO:0048708 IMP involved_in astrocyte differentiation 30186101 Process
18508 GO:0050680 IMP acts_upstream_of_or_within negative regulation of epithelial cell proliferation 16080917 Process
18508 GO:0050767 IMP acts_upstream_of_or_within regulation of neurogenesis 15548580 Process
18508 GO:0060041 IGI acts_upstream_of_or_within retina development in camera-type eye 19146846 Process
18508 GO:0061351 IMP acts_upstream_of neural precursor cell proliferation 23622063 Process
18508 GO:0080111 IMP involved_in DNA demethylation 30186101 Process
18508 GO:1990830 IEP acts_upstream_of_or_within cellular response to leukemia inhibitory factor 20439489 Process
18508 GO:2000178 IMP acts_upstream_of_or_within negative regulation of neural precursor cell proliferation 23622063 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18508 GO:0000785 IDA part_of chromatin 20592023 Component
18508 GO:0005622 IDA located_in intracellular anatomical structure 15793245 Component
18508 GO:0005634 IDA located_in nucleus 9230312,11209945,12050133,14625556,16464444,19409883,22764048,..... Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18508 GO:0000976 IDA enables transcription cis-regulatory region binding 19521500,23990468 Function
18508 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 12756174,20592023 Function
18508 GO:0000979 IDA enables RNA polymerase II core promoter sequence-specific DNA binding 16407227 Function
18508 GO:0000981 IDA enables DNA-binding transcription factor activity, RNA polymerase II-specific 16407227,20592023 Function
18508 GO:0001221 IPI enables transcription coregulator binding 16407227 Function
18508 GO:0001227 IDA enables DNA-binding transcription repressor activity, RNA polymerase II-specific 23622063 Function
18508 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 12756174,22031545 Function
18508 GO:0003677 IDA enables DNA binding 12756174 Function
18508 GO:0003682 IDA enables chromatin binding 19146846,23637604,24488179 Function
18508 GO:0003700 IDA enables DNA-binding transcription factor activity 18287938 Function
18508 GO:0003723 IDA enables RNA binding 24488179 Function
18508 GO:0005515 IPI enables protein binding 16098226,16675956,21084637,23447615,23990468 Function
18508 GO:0019901 IPI enables protein kinase binding 16407227 Function
18508 GO:0031490 IDA enables chromatin DNA binding 30186101 Function
18508 GO:0031625 IPI enables ubiquitin protein ligase binding 18628401 Function
18508 GO:0035035 IDA enables histone acetyltransferase binding 16407227 Function
18508 GO:0043565 IDA enables sequence-specific DNA binding 23622063 Function
18508 GO:0070410 IDA enables co-SMAD binding 17251190 Function
18508 GO:0070412 IDA enables R-SMAD binding 17251190 Function
18508 GO:0071837 IPI enables HMG box domain binding 16582099 Function