Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:18747
  • Symbol:Prkaca
  • Description:protein kinase, cAMP dependent, catalytic, alpha

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18747 GO:0000287 IDA enables magnesium ion binding 1862342 Function
18747 GO:0004672 IDA enables protein kinase activity 15465019,17855365,18202122 Function
18747 GO:0004674 IDA enables protein serine/threonine kinase activity 7905001,9413984,29473541 Function
18747 GO:0004674 IMP enables protein serine/threonine kinase activity 9688563 Function
18747 GO:0004691 IDA enables cAMP-dependent protein kinase activity 12200423,23292513,23349500,25475437 Function
18747 GO:0004691 IMP enables cAMP-dependent protein kinase activity 16155866 Function
18747 GO:0005515 IPI enables protein binding 10805756,12200423,12931191,14724137,15692043,16924114,21300294..... Function
18747 GO:0005524 IDA enables ATP binding 1862342 Function
18747 GO:0005524 IMP enables ATP binding 15692043 Function
18747 GO:0019904 IPI enables protein domain specific binding 1862342 Function
18747 GO:0030145 IMP enables manganese ion binding 15692043 Function
18747 GO:0034237 IPI enables protein kinase A regulatory subunit binding 15692043,30026308 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18747 GO:0001669 IDA located_in acrosomal vesicle 27105888 Component
18747 GO:0005634 IDA located_in nucleus 9218452 Component
18747 GO:0005737 IDA located_in cytoplasm 9218452,12004056 Component
18747 GO:0005739 IDA located_in mitochondrion 12931191 Component
18747 GO:0005829 IDA is_active_in cytosol 29967033 Component
18747 GO:0005886 IDA located_in plasma membrane 16782699 Component
18747 GO:0005952 IMP part_of cAMP-dependent protein kinase complex 15692043 Component
18747 GO:0031594 IDA located_in neuromuscular junction 8794865 Component
18747 GO:0036126 IDA located_in sperm flagellum 27105888 Component
18747 GO:0043197 IDA located_in dendritic spine 19447092 Component
18747 GO:0097546 IDA located_in ciliary base 22007132 Component
18747 GO:0098794 EXP located_in postsynapse 15590926 Component
18747 GO:0098978 EXP is_active_in glutamatergic synapse 15590926 Component
18747 GO:0098978 IDA is_active_in glutamatergic synapse 15590926 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
18747 GO:0001707 IGI acts_upstream_of_or_within mesoderm formation 12004056 Process
18747 GO:0001843 IGI acts_upstream_of_or_within neural tube closure 22007132 Process
18747 GO:0006468 IDA acts_upstream_of_or_within protein phosphorylation 9218452,15465019,16481613,17855365,18191828,18202122,19056373..... Process
18747 GO:0006611 IDA acts_upstream_of_positive_effect protein export from nucleus 18606808 Process
18747 GO:0006611 IMP acts_upstream_of protein export from nucleus 17043310 Process
18747 GO:0007189 IDA involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway 23349500,25475437 Process
18747 GO:0007189 IMP involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway 9075801 Process
18747 GO:0018105 IDA acts_upstream_of_or_within peptidyl-serine phosphorylation 7905001 Process
18747 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 9413984 Process
18747 GO:0018105 IMP involved_in peptidyl-serine phosphorylation 9688563 Process
18747 GO:0018107 IDA acts_upstream_of_or_within peptidyl-threonine phosphorylation 7905001 Process
18747 GO:0032024 IDA involved_in positive regulation of insulin secretion 23349500,25475437 Process
18747 GO:0032024 IMP involved_in positive regulation of insulin secretion 9075801 Process
18747 GO:0045722 IDA involved_in positive regulation of gluconeogenesis 23292513 Process
18747 GO:0046777 IDA acts_upstream_of_or_within protein autophosphorylation 17855365,18191828 Process
18747 GO:0046827 IMP acts_upstream_of_or_within positive regulation of protein export from nucleus 17043310 Process
18747 GO:0048240 IDA involved_in sperm capacitation 19560455 Process
18747 GO:0050804 IMP acts_upstream_of_or_within modulation of chemical synaptic transmission 15590926 Process
18747 GO:0051726 IDA involved_in regulation of cell cycle 19223768 Process
18747 GO:0070417 IMP acts_upstream_of_or_within cellular response to cold 30862682 Process
18747 GO:0070613 IGI acts_upstream_of_or_within regulation of protein processing 22007132 Process
18747 GO:0071374 IMP acts_upstream_of_or_within cellular response to parathyroid hormone stimulus 19723499 Process
18747 GO:0071377 IGI involved_in cellular response to glucagon stimulus 32735622 Process
18747 GO:0099170 EXP involved_in postsynaptic modulation of chemical synaptic transmission 15590926 Process
18747 GO:0099170 IDA involved_in postsynaptic modulation of chemical synaptic transmission 15590926 Process
18747 GO:1901621 IGI acts_upstream_of_or_within negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 22007132 Process
18747 GO:1904539 IDA involved_in negative regulation of glycolytic process through fructose-6-phosphate 23292513 Process
18747 GO:1904539 IMP involved_in negative regulation of glycolytic process through fructose-6-phosphate 16155866 Process
18747 GO:1990044 IMP acts_upstream_of_or_within protein localization to lipid droplet 30862682 Process