Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:1950
  • Symbol:EGF
  • Description:epidermal growth factor

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1950 GO:0001525 IDA involved_in angiogenesis 15611079 Process
1950 GO:0001938 IDA involved_in positive regulation of endothelial cell proliferation 31915155 Process
1950 GO:0002092 IDA involved_in positive regulation of receptor internalization 22732145 Process
1950 GO:0007173 IDA involved_in epidermal growth factor receptor signaling pathway 15611079,18567582,20353436,31915155 Process
1950 GO:0007173 IMP involved_in epidermal growth factor receptor signaling pathway 22732145 Process
1950 GO:0008284 IDA acts_upstream_of_or_within positive regulation of cell population proliferation 7736574 Process
1950 GO:0008284 IDA involved_in positive regulation of cell population proliferation 15611079,20388803 Process
1950 GO:0010595 IDA involved_in positive regulation of endothelial cell migration 31915155 Process
1950 GO:0010628 IDA involved_in positive regulation of gene expression 25678558 Process
1950 GO:0010800 IDA involved_in positive regulation of peptidyl-threonine phosphorylation 16314496 Process
1950 GO:0014068 IGI involved_in positive regulation of phosphatidylinositol 3-kinase signaling 31915155 Process
1950 GO:0030335 IDA involved_in positive regulation of cell migration 25678558 Process
1950 GO:0038029 IMP involved_in epidermal growth factor receptor signaling pathway via MAPK cascade 18722344 Process
1950 GO:0038134 IDA involved_in ERBB2-EGFR signaling pathway 11336639 Process
1950 GO:0042327 IDA involved_in positive regulation of phosphorylation 15611079 Process
1950 GO:0043406 IDA involved_in positive regulation of MAP kinase activity 15611079 Process
1950 GO:0043410 IDA involved_in positive regulation of MAPK cascade 18567582,31915155 Process
1950 GO:0045740 IMP involved_in positive regulation of DNA replication 18722344 Process
1950 GO:0045840 IDA involved_in positive regulation of mitotic nuclear division 15611079 Process
1950 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 16314496 Process
1950 GO:0051048 IDA involved_in negative regulation of secretion 10559227 Process
1950 GO:0051897 IDA involved_in positive regulation of protein kinase B signaling 31915155 Process
1950 GO:0070371 IDA involved_in ERK1 and ERK2 cascade 16314496 Process
1950 GO:0090263 IDA involved_in positive regulation of canonical Wnt signaling pathway 20302655 Process
1950 GO:0090279 IDA involved_in regulation of calcium ion import 19996314 Process
1950 GO:1900127 IDA involved_in positive regulation of hyaluronan biosynthetic process 17324121 Process
1950 GO:1902966 IDA involved_in positive regulation of protein localization to early endosome 22298428 Process
1950 GO:1905278 IDA involved_in positive regulation of epithelial tube formation 31915155 Process
1950 GO:2000008 IDA involved_in regulation of protein localization to cell surface 19996314 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1950 GO:0005085 IDA enables guanyl-nucleotide exchange factor activity 20353436 Function
1950 GO:0005515 IPI enables protein binding 2790960,9135143,12297050,12620237,17697999,21439278,21822280,2..... Function
1950 GO:0008083 IDA enables growth factor activity 7736574,15611079 Function
1950 GO:0030297 IDA enables transmembrane receptor protein tyrosine kinase activator activity 11336639 Function
1950 GO:0048018 IDA enables receptor ligand activity 11336639 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
1950 GO:0005615 HDA located_in extracellular space 16502470 Component
1950 GO:0005615 IDA is_active_in extracellular space 11336639 Component
1950 GO:0005765 HDA located_in lysosomal membrane 17897319 Component
1950 GO:0070062 HDA located_in extracellular exosome 19056867,23533145 Component
1950 GO:0070062 IDA located_in extracellular exosome 21082674 Component