Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2081
  • Symbol:ERN1
  • Description:endoplasmic reticulum to nucleus signaling 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2081 GO:0000287 IDA enables magnesium ion binding 9637683 Function
2081 GO:0004521 IDA enables RNA endonuclease activity 9637683,11779465,19328063,21317875 Function
2081 GO:0004674 IDA enables protein serine/threonine kinase activity 9637683,21317875 Function
2081 GO:0005161 IPI enables platelet-derived growth factor receptor binding 26315405 Function
2081 GO:0005515 IPI enables protein binding 11278723,15234121,16645094,18369366,19135427,19328063,20103773..... Function
2081 GO:0005524 IDA enables ATP binding 9637683 Function
2081 GO:0019899 IPI enables enzyme binding 23103912 Function
2081 GO:0030544 IPI enables Hsp70 protein binding 20625543 Function
2081 GO:0042802 IPI enables identical protein binding 12637535,21317875 Function
2081 GO:0042803 IDA enables protein homodimerization activity 29198525 Function
2081 GO:0042803 IPI enables protein homodimerization activity 21317875 Function
2081 GO:0043531 IDA enables ADP binding 21317875 Function
2081 GO:0051879 IDA enables Hsp90 protein binding 12446770 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2081 GO:0001935 IDA involved_in endothelial cell proliferation 23529610 Process
2081 GO:0006468 IDA involved_in protein phosphorylation 9637683 Process
2081 GO:0033120 IDA involved_in positive regulation of RNA splicing 11779464,19622636 Process
2081 GO:0034620 IDA involved_in cellular response to unfolded protein 19328063 Process
2081 GO:0034620 IMP involved_in cellular response to unfolded protein 20625543,21317875 Process
2081 GO:0034976 IDA involved_in response to endoplasmic reticulum stress 10650002 Process
2081 GO:0035924 IDA involved_in cellular response to vascular endothelial growth factor stimulus 23529610 Process
2081 GO:0036289 IDA involved_in peptidyl-serine autophosphorylation 20103773 Process
2081 GO:0036498 IDA involved_in IRE1-mediated unfolded protein response 9637683,11779465,19328063,29198525 Process
2081 GO:0036498 IMP involved_in IRE1-mediated unfolded protein response 28128204 Process
2081 GO:0043507 IDA involved_in positive regulation of JUN kinase activity 10650002 Process
2081 GO:0046777 IDA involved_in protein autophosphorylation 9637683,19328063 Process
2081 GO:0070054 IDA involved_in mRNA splicing, via endonucleolytic cleavage and ligation 11779464,19328063,19622636,21317875 Process
2081 GO:0070054 IMP involved_in mRNA splicing, via endonucleolytic cleavage and ligation 20625543,21317875 Process
2081 GO:0071333 IDA involved_in cellular response to glucose stimulus 20103773 Process
2081 GO:1900103 IMP involved_in positive regulation of endoplasmic reticulum unfolded protein response 16645094,28128204 Process
2081 GO:1901142 IDA involved_in insulin metabolic process 20103773 Process
2081 GO:1904707 IMP involved_in positive regulation of vascular associated smooth muscle cell proliferation 26315405 Process
2081 GO:1990579 IMP involved_in peptidyl-serine trans-autophosphorylation 21317875 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2081 GO:0005737 IDA located_in cytoplasm 19622636 Component
2081 GO:0005783 IDA located_in endoplasmic reticulum 23529610 Component
2081 GO:0005789 IDA located_in endoplasmic reticulum membrane 9637683 Component
2081 GO:1990604 IDA part_of IRE1-TRAF2-ASK1 complex 23000344 Component
2081 GO:1990630 IDA part_of IRE1-RACK1-PP2A complex 20103773 Component