Gene Ontology

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:21388
  • Symbol:Tbx5
  • Description:T-box 5

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21388 GO:0000977 IDA enables RNA polymerase II transcription regulatory region sequence-specific DNA binding 14550786 Function
21388 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 22728936 Function
21388 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 22728936,22898775 Function
21388 GO:0003677 IDA enables DNA binding 11555635,11572777,12490567,14978031 Function
21388 GO:0003700 IDA enables DNA-binding transcription factor activity 11555635,11572777,12490567,14978031 Function
21388 GO:0005515 IPI enables protein binding 11572777,16380715,22192413,23028370,26859351,28164238..... Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21388 GO:0002009 IMP acts_upstream_of_or_within morphogenesis of an epithelium 12508227 Process
21388 GO:0003163 IMP involved_in sinoatrial node development 11572777 Process
21388 GO:0003166 IGI acts_upstream_of_or_within bundle of His development 17604724 Process
21388 GO:0003166 IMP involved_in bundle of His development 22728936 Process
21388 GO:0003167 IMP involved_in atrioventricular bundle cell differentiation 15289437 Process
21388 GO:0003181 IGI acts_upstream_of_or_within atrioventricular valve morphogenesis 19084512 Process
21388 GO:0003197 IGI acts_upstream_of_or_within endocardial cushion development 19084512 Process
21388 GO:0003218 IMP involved_in cardiac left ventricle formation 19727199 Process
21388 GO:0003229 IGI acts_upstream_of_or_within ventricular cardiac muscle tissue development 19084512 Process
21388 GO:0003281 IMP involved_in ventricular septum development 19727199 Process
21388 GO:0003283 IMP acts_upstream_of_or_within atrial septum development 19084512 Process
21388 GO:0006355 IMP acts_upstream_of_or_within regulation of DNA-templated transcription 16870172 Process
21388 GO:0006366 IGI acts_upstream_of transcription by RNA polymerase II 17604724 Process
21388 GO:0007389 IMP acts_upstream_of_or_within pattern specification process 15289437 Process
21388 GO:0007507 IMP acts_upstream_of_or_within heart development 11572777,15289437,16870172 Process
21388 GO:0030324 IMP acts_upstream_of_or_within lung development 12508227 Process
21388 GO:0030326 IGI acts_upstream_of_or_within embryonic limb morphogenesis 16380715 Process
21388 GO:0030326 IMP acts_upstream_of_or_within embryonic limb morphogenesis 12736217 Process
21388 GO:0035115 IMP acts_upstream_of_or_within embryonic forelimb morphogenesis 11572777,12490567 Process
21388 GO:0035136 IMP acts_upstream_of_or_within forelimb morphogenesis 15621531 Process
21388 GO:0045893 IDA acts_upstream_of_or_within positive regulation of DNA-templated transcription 11555635,11572777,12490567,14978031,15843409 Process
21388 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 22728936 Process
21388 GO:0045944 IGI acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 16380715,17604724 Process
21388 GO:0045944 IMP acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II 24565863 Process
21388 GO:0055007 IGI acts_upstream_of_or_within cardiac muscle cell differentiation 20691899 Process
21388 GO:0055007 IMP involved_in cardiac muscle cell differentiation 11431700 Process
21388 GO:0060038 IGI acts_upstream_of cardiac muscle cell proliferation 19084512 Process
21388 GO:0060045 IGI acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation 19084512 Process
21388 GO:0060371 IGI acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization 22728936 Process
21388 GO:0060413 IGI acts_upstream_of_or_within atrial septum morphogenesis 22898775 Process
21388 GO:0060928 IMP involved_in atrioventricular node cell development 15289437 Process
21388 GO:0060929 IMP involved_in atrioventricular node cell fate commitment 15289437 Process
21388 GO:0072513 IMP acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation 22898775 Process
21388 GO:0086019 IGI acts_upstream_of_or_within cell-cell signaling involved in cardiac conduction 22728936 Process
21388 GO:0086054 IMP acts_upstream_of_or_within bundle of His cell to Purkinje myocyte communication by electrical coupling 22728936 Process
21388 GO:1903598 IMP involved_in positive regulation of gap junction assembly 22728936 Process
21388 GO:1903781 IMP acts_upstream_of positive regulation of cardiac conduction 22728936 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
21388 GO:0005634 IDA located_in nucleus 11572777,14550786,16684884 Component
21388 GO:0005667 IPI part_of transcription regulator complex 18285513 Component