Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2146
  • Symbol:EZH2
  • Description:enhancer of zeste 2 polycomb repressive complex 2 subunit

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2146 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 20154697 Process
2146 GO:0008284 IMP involved_in positive regulation of cell population proliferation 18713946 Process
2146 GO:0010718 IDA involved_in positive regulation of epithelial to mesenchymal transition 20154697 Process
2146 GO:0031509 IGI involved_in subtelomeric heterochromatin formation 9214638 Process
2146 GO:0042752 IMP involved_in regulation of circadian rhythm 16717091 Process
2146 GO:0043406 IDA involved_in positive regulation of MAP kinase activity 20154697 Process
2146 GO:0043547 IDA involved_in positive regulation of GTPase activity 20154697 Process
2146 GO:0045814 IDA involved_in negative regulation of gene expression, epigenetic 20154697 Process
2146 GO:0045814 IMP involved_in negative regulation of gene expression, epigenetic 24623306 Process
2146 GO:0045892 IMP involved_in negative regulation of DNA-templated transcription 16179254 Process
2146 GO:0048387 IMP involved_in negative regulation of retinoic acid receptor signaling pathway 16179254 Process
2146 GO:0071902 IDA involved_in positive regulation of protein serine/threonine kinase activity 20154697 Process
2146 GO:1902808 IMP involved_in positive regulation of cell cycle G1/S phase transition 18713946 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2146 GO:0000781 IGI located_in chromosome, telomeric region 9214638 Component
2146 GO:0000785 IDA part_of chromatin 19734898 Component
2146 GO:0005634 IDA located_in nucleus 19144645 Component
2146 GO:0005654 IDA located_in nucleoplasm Component
2146 GO:0035098 IDA part_of ESC/E(Z) complex 15385962,20075857,23104054,23273982,24474760 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2146 GO:0001222 IPI enables transcription corepressor binding 29628311 Function
2146 GO:0003682 IDA enables chromatin binding 20154697 Function
2146 GO:0005515 IPI enables protein binding 11571280,16179254,16357870,17560333,19734898,20075857,20543829..... Function
2146 GO:0016279 IDA enables protein-lysine N-methyltransferase activity 19144645 Function
2146 GO:0031490 IDA enables chromatin DNA binding 19734898 Function
2146 GO:0042054 IDA enables histone methyltransferase activity 15385962 Function
2146 GO:0042054 IMP enables histone methyltransferase activity 26694085 Function
2146 GO:0046976 IDA enables histone H3K27 methyltransferase activity 22323599 Function
2146 GO:0046976 IMP enables histone H3K27 methyltransferase activity 28229514,30026490 Function
2146 GO:1990841 IDA enables promoter-specific chromatin binding 24623306 Function