Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:219931
• Symbol:TPCN2
• Description:two pore segment channel 2

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
219931	GO:0005245	IDA	NOT enables	voltage-gated calcium channel activity	23063126	Function
219931	GO:0005248	IDA	NOT enables	voltage-gated sodium channel activity	24776928	Function
219931	GO:0005262	IDA	enables	calcium channel activity	27140606	Function
219931	GO:0005515	IPI	enables	protein binding	21903581,23394946,24188827	Function
219931	GO:0015280	IDA	enables	ligand-gated sodium channel activity	23063126,30860481,32167471	Function
219931	GO:0019901	IPI	enables	protein kinase binding	22012985	Function
219931	GO:0042802	IDA	enables	identical protein binding	30860481	Function
219931	GO:0042802	IPI	enables	identical protein binding	21903581	Function
219931	GO:0072345	IDA	NOT enables	NAADP-sensitive calcium-release channel activity	23063126	Function
219931	GO:0072345	IDA	enables	NAADP-sensitive calcium-release channel activity	19387438,19620632,20880839,32167471	Function
219931	GO:0080025	IDA	enables	phosphatidylinositol-3,5-bisphosphate binding	23063126,30860481	Function
219931	GO:0097682	IDA	enables	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	23063126,30860481,32167471	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
219931	GO:0005764	IDA	located_in	lysosome	22012985	Component
219931	GO:0005765	IDA	located_in	lysosomal membrane	19387438,19620632,20880839,23063126	Component
219931	GO:0010008	IDA	located_in	endosome membrane	19620632	Component
219931	GO:0033162	IDA	located_in	melanosome membrane	27140606	Component
219931	GO:0036020	IDA	located_in	endolysosome membrane	32167471	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
219931	GO:0006874	IDA	involved_in	intracellular calcium ion homeostasis	19387438	Process
219931	GO:0007040	IGI	involved_in	lysosome organization	25416817	Process
219931	GO:0010506	IGI	involved_in	regulation of autophagy	22012985	Process
219931	GO:0019065	IDA	involved_in	receptor-mediated endocytosis of virus by host cell	32221306	Process
219931	GO:0019722	IGI	involved_in	calcium-mediated signaling	25416817	Process
219931	GO:0035725	IDA	involved_in	sodium ion transmembrane transport	30860481	Process
219931	GO:0048086	IDA	involved_in	negative regulation of developmental pigmentation	27140606	Process
219931	GO:0051452	IDA	involved_in	intracellular pH reduction	27140606	Process
219931	GO:0075509	IMP	involved_in	endocytosis involved in viral entry into host cell	25722412	Process