Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2200
  • Symbol:FBN1
  • Description:fibrillin 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2200 GO:0001501 IMP involved_in skeletal system development 8188302 Process
2200 GO:0007507 IMP involved_in heart development 15781745 Process
2200 GO:0033627 IDA involved_in cell adhesion mediated by integrin 12807887,17158881 Process
2200 GO:0043010 IEP involved_in camera-type eye development 25406291 Process
2200 GO:0045671 IDA involved_in negative regulation of osteoclast differentiation 24039232 Process
2200 GO:0048048 IEP involved_in embryonic eye morphogenesis 25406291 Process
2200 GO:0048050 IEP involved_in post-embryonic eye morphogenesis 25406291 Process
2200 GO:2001205 IDA involved_in negative regulation of osteoclast development 24039232 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2200 GO:0001527 IDA located_in microfibril 1860873,3536967,7534784,8120105,10424889,12429738,22355679..... Component
2200 GO:0005576 HDA located_in extracellular region 27068509 Component
2200 GO:0005576 IDA located_in extracellular region 11461921,34411563 Component
2200 GO:0005604 IDA located_in basement membrane 3536967 Component
2200 GO:0005615 HDA located_in extracellular space 20551380 Component
2200 GO:0005615 IDA located_in extracellular space 3536967 Component
2200 GO:0031012 IDA located_in extracellular matrix 3536967 Component
2200 GO:0062023 HDA colocalizes_with collagen-containing extracellular matrix 20551380 Component
2200 GO:0062023 HDA located_in collagen-containing extracellular matrix 23658023,23979707,25037231,27559042,28327460,28675934..... Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2200 GO:0005178 IPI enables integrin binding 12807887,15062093,17158881 Function
2200 GO:0005201 IDA enables extracellular matrix structural constituent 3536967 Function
2200 GO:0005509 IDA enables calcium ion binding 7691719,15062093 Function
2200 GO:0005515 IPI enables protein binding 12429738,15131124,15165854,15790312,17293099,18339631,19349279..... Function
2200 GO:0008201 IDA enables heparin binding 11461921 Function
2200 GO:0042802 IPI enables identical protein binding 18448684,24035709,25034023 Function
2200 GO:0044877 IPI enables protein-containing complex binding 15062093 Function