Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2214
  • Symbol:FCGR3A
  • Description:Fc fragment of IgG receptor IIIa

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2214 GO:0001788 IDA involved_in antibody-dependent cellular cytotoxicity 11711607,27670158,28652325 Process
2214 GO:0014065 IDA involved_in phosphatidylinositol 3-kinase signaling 23024279 Process
2214 GO:0019722 IDA involved_in calcium-mediated signaling 23024279 Process
2214 GO:0030101 IDA involved_in natural killer cell activation 9916693 Process
2214 GO:0030101 IMP involved_in natural killer cell activation 23006327 Process
2214 GO:0032760 IDA involved_in positive regulation of tumor necrosis factor production 10728755 Process
2214 GO:0032819 IDA involved_in positive regulation of natural killer cell proliferation 9916693 Process
2214 GO:0038094 IDA involved_in Fc-gamma receptor signaling pathway 8478617,23024279 Process
2214 GO:0042116 IDA involved_in macrophage activation 10728755 Process
2214 GO:0042267 IDA involved_in natural killer cell mediated cytotoxicity 10318937,23006327 Process
2214 GO:0043320 IDA involved_in natural killer cell degranulation 25786175,28652325 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2214 GO:0005515 IPI enables protein binding 2532305,23006327,23024279,34158475 Function
2214 GO:0019772 IDA enables low-affinity IgG receptor activity 11711607 Function
2214 GO:0140375 IDA enables immune receptor activity 10318937 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2214 GO:0005615 IDA located_in extracellular space 24337742 Component
2214 GO:0005886 IDA located_in plasma membrane 1825220,2532305,23006327,24337742,27670158,28652325..... Component
2214 GO:0009897 IDA located_in external side of plasma membrane 10706735,24942581 Component
2214 GO:0033001 IDA part_of Fc-gamma receptor III complex 1825220,28652325 Component
2214 GO:0070062 HDA located_in extracellular exosome 23533145 Component