Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:22900
  • Symbol:CARD8
  • Description:caspase recruitment domain family member 8

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22900 GO:0005515 IPI enables protein binding 11551959,15030775,31525884 Function
22900 GO:0008656 IDA enables cysteine-type endopeptidase activator activity involved in apoptotic process 15030775 Function
22900 GO:0032089 IPI enables NACHT domain binding 15030775 Function
22900 GO:0038187 IDA enables pattern recognition receptor activity 33542150 Function
22900 GO:0042803 IDA enables protein homodimerization activity 15030775 Function
22900 GO:0050700 IPI enables CARD domain binding 11821383 Function
22900 GO:0140608 IDA enables cysteine-type endopeptidase activator activity 31525884 Function
22900 GO:0140693 IDA enables molecular condensate scaffold activity 33053349 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22900 GO:0005634 IDA located_in nucleus 11551959 Component
22900 GO:0005654 IDA located_in nucleoplasm Component
22900 GO:0005737 IDA is_active_in cytoplasm 24517500 Component
22900 GO:0005737 IDA located_in cytoplasm 15030775 Component
22900 GO:0032991 IDA part_of protein-containing complex 11821383 Component
22900 GO:0072559 IDA part_of NLRP3 inflammasome complex 15030775 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
22900 GO:0010804 IMP involved_in negative regulation of tumor necrosis factor-mediated signaling pathway 11821383 Process
22900 GO:0031665 IDA involved_in negative regulation of lipopolysaccharide-mediated signaling pathway 11821383 Process
22900 GO:0032088 IMP involved_in negative regulation of NF-kappaB transcription factor activity 11821383 Process
22900 GO:0032691 IDA involved_in negative regulation of interleukin-1 beta production 11821383 Process
22900 GO:0032731 IDA involved_in positive regulation of interleukin-1 beta production 15030775 Process
22900 GO:0043124 IDA involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling 11551959 Process
22900 GO:0043280 IDA involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 11821383,15030775 Process
22900 GO:0051607 IDA involved_in defense response to virus 33542150 Process
22900 GO:0097264 IDA involved_in self proteolysis 33542150 Process
22900 GO:0097340 IDA involved_in inhibition of cysteine-type endopeptidase activity 11821383 Process
22900 GO:0140374 IDA involved_in antiviral innate immune response 33542150 Process
22900 GO:0140633 IDA involved_in CARD8 inflammasome complex assembly 31525884,33053349,33420033 Process
22900 GO:1900226 IDA involved_in negative regulation of NLRP3 inflammasome complex assembly 24517500 Process