Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2321
  • Symbol:FLT1
  • Description:fms related receptor tyrosine kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2321 GO:0002548 IDA involved_in monocyte chemotaxis 8605350,18079407 Process
2321 GO:0010863 IMP involved_in positive regulation of phospholipase C activity 11312102 Process
2321 GO:0014068 IMP involved_in positive regulation of phosphatidylinositol 3-kinase signaling 14633857 Process
2321 GO:0016477 IMP involved_in cell migration 8605350 Process
2321 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 9299537,11513746 Process
2321 GO:0030335 IDA involved_in positive regulation of cell migration 8605350 Process
2321 GO:0035924 IDA involved_in cellular response to vascular endothelial growth factor stimulus 8605350 Process
2321 GO:0036323 IDA involved_in vascular endothelial growth factor receptor-1 signaling pathway 15952180 Process
2321 GO:0043406 IDA involved_in positive regulation of MAP kinase activity 9299537 Process
2321 GO:0043410 IDA involved_in positive regulation of MAPK cascade 9299537 Process
2321 GO:0043552 IMP involved_in positive regulation of phosphatidylinositol 3-kinase activity 11312102 Process
2321 GO:0045766 IMP involved_in positive regulation of angiogenesis 14633857,28637396 Process
2321 GO:0046777 IDA involved_in protein autophosphorylation 9299537,11513746 Process
2321 GO:0048010 IDA involved_in vascular endothelial growth factor receptor signaling pathway 1312256,9299537 Process
2321 GO:0048010 IMP involved_in vascular endothelial growth factor receptor signaling pathway 11312102 Process
2321 GO:1905563 IGI involved_in negative regulation of vascular endothelial cell proliferation 22955733 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2321 GO:0005021 IDA enables vascular endothelial growth factor receptor activity 1312256,8605350,9299537,15952180 Function
2321 GO:0005021 IMP enables vascular endothelial growth factor receptor activity 11312102 Function
2321 GO:0005515 IPI enables protein binding 1312256,7657594,9393862,10543948,12771128,14684734,16893970,18..... Function
2321 GO:0019838 IPI enables growth factor binding 1312256,10471394,11513746,12366396,16109918 Function
2321 GO:0036332 IDA enables placental growth factor receptor activity 12796773 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2321 GO:0005886 IDA located_in plasma membrane 11513746 Component
2321 GO:0005925 HDA located_in focal adhesion 21423176 Component
2321 GO:0015629 IDA located_in actin cytoskeleton Component
2321 GO:0043235 IDA part_of receptor complex 23382219 Component