Gene Ontology

Gene Info

  • Species:Rat (Rattus norvegicus)
  • GeneID:25238
  • Symbol:Grk2
  • Description:G protein-coupled receptor kinase 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25238 GO:0001664 IPI enables G protein-coupled receptor binding 26228571 Function
25238 GO:0004703 IDA enables G protein-coupled receptor kinase activity 1403099 Function
25238 GO:0005515 IPI enables protein binding 15626685,27568556 Function
25238 GO:0031625 IPI enables ubiquitin protein ligase binding 26228571 Function
25238 GO:0031850 IPI enables delta-type opioid receptor binding 28381559 Function
25238 GO:0031851 IPI enables kappa-type opioid receptor binding 27865836 Function
25238 GO:0047696 IDA enables beta-adrenergic receptor kinase activity 1403099 Function
25238 GO:0097110 IPI enables scaffold protein binding 28162981 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25238 GO:0002029 IDA involved_in desensitization of G protein-coupled receptor signaling pathway 18223549 Process
25238 GO:0002029 IMP involved_in desensitization of G protein-coupled receptor signaling pathway 17908240,30075183 Process
25238 GO:0006468 IDA involved_in protein phosphorylation 1403099 Process
25238 GO:0006468 IMP involved_in protein phosphorylation 23690069 Process
25238 GO:0006979 IDA involved_in response to oxidative stress 16478977 Process
25238 GO:0007186 IDA involved_in G protein-coupled receptor signaling pathway 12021252 Process
25238 GO:0007186 IEP involved_in G protein-coupled receptor signaling pathway 29081032 Process
25238 GO:0010661 IMP involved_in positive regulation of muscle cell apoptotic process 26631573 Process
25238 GO:0010801 IMP involved_in negative regulation of peptidyl-threonine phosphorylation 26660861 Process
25238 GO:0014070 IDA involved_in response to organic cyclic compound 16478977 Process
25238 GO:0014850 IEP involved_in response to muscle activity 23913704 Process
25238 GO:0032755 IMP involved_in positive regulation of interleukin-6 production 28193640 Process
25238 GO:0033137 IMP involved_in negative regulation of peptidyl-serine phosphorylation 26660861 Process
25238 GO:0033605 IDA involved_in positive regulation of catecholamine secretion 18223549 Process
25238 GO:0042311 IMP involved_in vasodilation 23913704 Process
25238 GO:0042542 IEP involved_in response to hydrogen peroxide 16337875 Process
25238 GO:0042699 IDA involved_in follicle-stimulating hormone signaling pathway 16899567 Process
25238 GO:0043066 IMP involved_in negative regulation of apoptotic process 26849467 Process
25238 GO:0044321 IEP involved_in response to leptin 23073237 Process
25238 GO:0045744 IDA involved_in negative regulation of G protein-coupled receptor signaling pathway 1403099 Process
25238 GO:0045907 IMP involved_in positive regulation of vasoconstriction 28882814 Process
25238 GO:0046325 IMP involved_in negative regulation of glucose import 26660861 Process
25238 GO:0048146 IMP involved_in positive regulation of fibroblast proliferation 27862165 Process
25238 GO:0048709 IEP involved_in oligodendrocyte differentiation 24613411 Process
25238 GO:0048709 IMP involved_in oligodendrocyte differentiation 24613411 Process
25238 GO:0051457 IMP involved_in maintenance of protein location in nucleus 28759639 Process
25238 GO:0061771 IEP involved_in response to caloric restriction 23073237 Process
25238 GO:0071333 IDA involved_in cellular response to glucose stimulus 27865836 Process
25238 GO:0071364 IMP involved_in cellular response to epidermal growth factor stimulus 24018045 Process
25238 GO:0071407 IEP involved_in cellular response to organic cyclic compound 23467820 Process
25238 GO:0071870 IEP involved_in cellular response to catecholamine stimulus 26849467 Process
25238 GO:0072752 IEP involved_in cellular response to rapamycin 26228571 Process
25238 GO:0106072 IMP involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 30075183 Process
25238 GO:1900077 IMP involved_in negative regulation of cellular response to insulin stimulus 23913704 Process
25238 GO:1904628 IEP involved_in cellular response to phorbol 13-acetate 12-myristate 29905975 Process
25238 GO:1904707 IMP involved_in positive regulation of vascular associated smooth muscle cell proliferation 24018045,27773680 Process
25238 GO:1990869 IDA involved_in cellular response to chemokine 23221335 Process
25238 GO:2000117 IMP involved_in negative regulation of cysteine-type endopeptidase activity 23690069 Process
25238 GO:2000463 IMP involved_in positive regulation of excitatory postsynaptic potential 28975565 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
25238 GO:0005901 IDA located_in caveola 15626685 Component
25238 GO:0014069 IDA is_active_in postsynaptic density 1403099 Component
25238 GO:0016323 IDA located_in basolateral plasma membrane 16899567 Component
25238 GO:0016324 IDA located_in apical plasma membrane 16899567 Component
25238 GO:0030424 IDA located_in axon 1403099 Component
25238 GO:0043197 IDA located_in dendritic spine 1403099 Component
25238 GO:0043198 IDA located_in dendritic shaft 1403099 Component
25238 GO:0098793 IDA is_active_in presynapse 1403099 Component
25238 GO:0098978 IDA is_active_in glutamatergic synapse 1403099 Component