Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2633
  • Symbol:GBP1
  • Description:guanylate binding protein 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2633 GO:0003779 IDA enables actin binding 24337748 Function
2633 GO:0003924 IDA enables GTPase activity 7512561,10676968,16511497,28645896,29144452,29233899,31268602..... Function
2633 GO:0003925 IDA enables G protein activity 7512561,16511497,28645896,29144452,29233899 Function
2633 GO:0004382 IDA enables GDP phosphatase activity 7512561,16511497,28645896 Function
2633 GO:0005515 IPI enables protein binding 21151871,24337748,28514442 Function
2633 GO:0005525 IDA enables GTP binding 10676968,10970849 Function
2633 GO:0019003 IDA enables GDP binding 10676968 Function
2633 GO:0019899 IPI enables enzyme binding 24337748 Function
2633 GO:0019955 IPI enables cytokine binding 24337748 Function
2633 GO:0030507 IPI enables spectrin binding 24337748 Function
2633 GO:0042802 IPI enables identical protein binding 16511497,21151871,22059445,22607347 Function
2633 GO:0042803 IDA enables protein homodimerization activity 10676968,21151871 Function
2633 GO:0051879 IPI enables Hsp90 protein binding 24337748 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2633 GO:0005737 IDA located_in cytoplasm 17266443,21151871 Component
2633 GO:0005794 IDA located_in Golgi apparatus 17266443 Component
2633 GO:0005829 IDA located_in cytosol 24337748 Component
2633 GO:0012506 IDA is_active_in vesicle membrane 29144452,29233899 Component
2633 GO:0012506 IDA located_in vesicle membrane 21151871,31268602 Component
2633 GO:0015629 IDA located_in actin cytoskeleton 21151871 Component
2633 GO:0031410 IDA is_active_in cytoplasmic vesicle 29144452 Component
2633 GO:0106139 IDA is_active_in symbiont cell surface 29144452,29233899 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2633 GO:0032703 IMP involved_in negative regulation of interleukin-2 production 24337748 Process
2633 GO:0042832 IDA involved_in defense response to protozoan 31268602 Process
2633 GO:0045087 IDA involved_in innate immune response 29144452 Process
2633 GO:0050848 IMP involved_in regulation of calcium-mediated signaling 24337748 Process
2633 GO:0050860 IMP involved_in negative regulation of T cell receptor signaling pathway 24337748 Process
2633 GO:0051715 IDA involved_in cytolysis in another organism 31268602 Process
2633 GO:0070373 IMP involved_in negative regulation of ERK1 and ERK2 cascade 24337748 Process
2633 GO:0071346 IDA involved_in cellular response to type II interferon 17266443,21151871 Process
2633 GO:0071347 IEP involved_in cellular response to interleukin-1 17266443 Process
2633 GO:0071356 IEP involved_in cellular response to tumor necrosis factor 17266443 Process
2633 GO:0072665 IDA involved_in protein localization to vacuole 21151871 Process
2633 GO:0140639 IDA involved_in positive regulation of pyroptosis 31268602 Process
2633 GO:0160075 IDA involved_in non-canonical inflammasome complex assembly 31268602 Process
2633 GO:1900025 IMP involved_in negative regulation of substrate adhesion-dependent cell spreading 24337748 Process
2633 GO:1903076 IGI involved_in regulation of protein localization to plasma membrane 24337748 Process
2633 GO:1903077 IMP involved_in negative regulation of protein localization to plasma membrane 24337748 Process