Gene Ontology

Gene Info

• Species:Mouse (Mus musculus)
• GeneID:269523
• Symbol:Vcp
• Description:valosin containing protein

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
269523	GO:0005515	IPI	enables	protein binding	10811609,11689694,12504083,12847084,14561754,14988733,15215856.....	Function
269523	GO:0005524	IDA	enables	ATP binding	12847084	Function
269523	GO:0005524	IMP	enables	ATP binding	15740751	Function
269523	GO:0016887	IDA	enables	ATP hydrolysis activity	12847084	Function
269523	GO:0031593	IDA	enables	polyubiquitin modification-dependent protein binding	11483959	Function
269523	GO:0036435	IDA	enables	K48-linked polyubiquitin modification-dependent protein binding	12847084	Function
269523	GO:0042288	IDA	enables	MHC class I protein binding	12847084	Function
269523	GO:0042802	IPI	enables	identical protein binding	15740751,18462676,22232657	Function
269523	GO:0043531	IMP	enables	ADP binding	15740751	Function
269523	GO:1990381	IPI	enables	ubiquitin-specific protease binding	17000876	Function

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
269523	GO:0005789	IDA	located_in	endoplasmic reticulum membrane	12847084	Component
269523	GO:0032991	IPI	part_of	protein-containing complex	17785525	Component
269523	GO:0034098	EXP	part_of	VCP-NPL4-UFD1 AAA ATPase complex	22232657	Component
269523	GO:0034098	IDA	part_of	VCP-NPL4-UFD1 AAA ATPase complex	10811609,17000876	Component
269523	GO:0034098	IPI	part_of	VCP-NPL4-UFD1 AAA ATPase complex	12847084	Component
269523	GO:0036513	IDA	part_of	Derlin-1 retrotranslocation complex	15215856	Component
269523	GO:0043209	HDA	located_in	myelin sheath	17634366	Component
269523	GO:0045202	EXP	is_active_in	synapse	16635246,24534009	Component
269523	GO:0045202	IDA	is_active_in	synapse	16635246,24534009	Component
269523	GO:1904949	IMP	part_of	ATPase complex	15740751	Component
269523	GO:1990730	IPI	part_of	VCP-NSFL1C complex	10811609,12847084,14988733	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
269523	GO:0006511	IGI	acts_upstream_of_or_within	ubiquitin-dependent protein catabolic process	16810319	Process
269523	GO:0006919	IDA	acts_upstream_of_or_within	activation of cysteine-type endopeptidase activity involved in apoptotic process	14561754	Process
269523	GO:0010918	IMP	involved_in	positive regulation of mitochondrial membrane potential	23498975	Process
269523	GO:0030433	EXP	involved_in	ubiquitin-dependent ERAD pathway	12847084	Process
269523	GO:0030970	EXP	involved_in	retrograde protein transport, ER to cytosol	12847084	Process
269523	GO:0030970	IMP	involved_in	retrograde protein transport, ER to cytosol	12847084	Process
269523	GO:0043161	IMP	involved_in	proteasome-mediated ubiquitin-dependent protein catabolic process	26692333	Process
269523	GO:0046034	IDA	involved_in	ATP metabolic process	12847084	Process
269523	GO:0070842	IGI	acts_upstream_of_or_within	aggresome assembly	16810319	Process