Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:29108
  • Symbol:PYCARD
  • Description:PYD and CARD domain containing

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29108 GO:0000139 IDA located_in Golgi membrane 23229815 Component
29108 GO:0005654 IDA located_in nucleoplasm Component
29108 GO:0005730 IDA located_in nucleolus Component
29108 GO:0005737 IDA located_in cytoplasm 14730312,15030775,19158679 Component
29108 GO:0005739 IDA located_in mitochondrion 14730312 Component
29108 GO:0005829 IDA located_in cytosol Component
29108 GO:0032991 IDA part_of protein-containing complex 22267217 Component
29108 GO:0061702 IPI part_of canonical inflammasome complex 16037825 Component
29108 GO:0072558 IDA part_of NLRP1 inflammasome complex 12191486 Component
29108 GO:0072558 IPI part_of NLRP1 inflammasome complex 17349957 Component
29108 GO:0072559 IDA part_of NLRP3 inflammasome complex 15030775 Component
29108 GO:0072559 IPI part_of NLRP3 inflammasome complex 29255148 Component
29108 GO:0097169 IDA part_of AIM2 inflammasome complex 19158676 Component
29108 GO:0097169 IPI part_of AIM2 inflammasome complex 24630722 Component
29108 GO:0140738 IDA part_of NLRP6 inflammasome complex 30674671,34678144 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29108 GO:0001773 IMP involved_in myeloid dendritic cell activation 22732093 Process
29108 GO:0002218 IDA involved_in activation of innate immune response 21575908 Process
29108 GO:0002821 IMP involved_in positive regulation of adaptive immune response 22732093 Process
29108 GO:0010803 IMP involved_in regulation of tumor necrosis factor-mediated signaling pathway 14730312 Process
29108 GO:0032088 IMP involved_in negative regulation of NF-kappaB transcription factor activity 16585594 Process
29108 GO:0032688 IMP involved_in negative regulation of interferon-beta production 19158675 Process
29108 GO:0032722 IMP involved_in positive regulation of chemokine production 21487011 Process
29108 GO:0032731 IDA involved_in positive regulation of interleukin-1 beta production 7642516,15030775,16037825,24630722 Process
29108 GO:0032731 IMP involved_in positive regulation of interleukin-1 beta production 22267217 Process
29108 GO:0032733 IMP involved_in positive regulation of interleukin-10 production 16982856 Process
29108 GO:0032755 IMP involved_in positive regulation of interleukin-6 production 16982856 Process
29108 GO:0032757 IMP involved_in positive regulation of interleukin-8 production 16982856 Process
29108 GO:0032760 IMP involved_in positive regulation of tumor necrosis factor production 16982856,21487011 Process
29108 GO:0033209 IDA involved_in tumor necrosis factor-mediated signaling pathway 12656673 Process
29108 GO:0042771 IMP involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 14730312 Process
29108 GO:0043065 IDA involved_in positive regulation of apoptotic process 12646168 Process
29108 GO:0043124 IDA involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling 12486103 Process
29108 GO:0043280 IDA involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 15030775 Process
29108 GO:0043280 IMP involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 22267217 Process
29108 GO:0044546 IDA involved_in NLRP3 inflammasome complex assembly 27432880 Process
29108 GO:0046330 IMP involved_in positive regulation of JNK cascade 21487011 Process
29108 GO:0050729 IDA involved_in positive regulation of inflammatory response 12191486 Process
29108 GO:0050829 IMP involved_in defense response to Gram-negative bacterium 16982856,21487011 Process
29108 GO:0050870 IMP involved_in positive regulation of T cell activation 22732093 Process
29108 GO:0051091 IDA involved_in positive regulation of DNA-binding transcription factor activity 19494289 Process
29108 GO:0051092 IDA involved_in positive regulation of NF-kappaB transcription factor activity 12646168,12656673 Process
29108 GO:0051260 IDA involved_in protein homooligomerization 24531343 Process
29108 GO:0051607 IDA involved_in defense response to virus 21575908 Process
29108 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 21487011 Process
29108 GO:0071222 IDA involved_in cellular response to lipopolysaccharide 12486103 Process
29108 GO:0071347 IDA involved_in cellular response to interleukin-1 12486103 Process
29108 GO:0071356 IDA involved_in cellular response to tumor necrosis factor 12486103 Process
29108 GO:0071901 IDA involved_in negative regulation of protein serine/threonine kinase activity 12486103 Process
29108 GO:0072332 IMP involved_in intrinsic apoptotic signaling pathway by p53 class mediator 14730312 Process
29108 GO:0090200 IDA involved_in positive regulation of release of cytochrome c from mitochondria 14730312 Process
29108 GO:1900016 IMP involved_in negative regulation of cytokine production involved in inflammatory response 24531343 Process
29108 GO:1901224 IPI involved_in positive regulation of NIK/NF-kappaB signaling 15817483 Process
29108 GO:2001056 IDA involved_in positive regulation of cysteine-type endopeptidase activity 19158676 Process
29108 GO:2001238 IDA involved_in positive regulation of extrinsic apoptotic signaling pathway 16964285 Process
29108 GO:2001242 IDA involved_in regulation of intrinsic apoptotic signaling pathway 14730312 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
29108 GO:0002020 IPI enables protease binding 24407287 Function
29108 GO:0005138 IPI enables interleukin-6 receptor binding 24407287 Function
29108 GO:0005515 IPI enables protein binding 11498534,11786556,12019269,12656673,14730312,15020601,15030775..... Function
29108 GO:0005523 IPI enables tropomyosin binding 24407287 Function
29108 GO:0017024 IPI enables myosin I binding 24407287 Function
29108 GO:0019899 IPI enables enzyme binding 24407287 Function
29108 GO:0032090 IPI enables Pyrin domain binding 15030775 Function
29108 GO:0042802 IDA enables identical protein binding 34341353 Function
29108 GO:0042802 IPI enables identical protein binding 24630722,25006247,25416956 Function
29108 GO:0042803 IDA enables protein homodimerization activity 15030775 Function
29108 GO:0046983 IDA enables protein dimerization activity 24531343 Function
29108 GO:0070700 IPI enables BMP receptor binding 24407287 Function