Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:2932
  • Symbol:GSK3B
  • Description:glycogen synthase kinase 3 beta

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2932 GO:0001837 IMP involved_in epithelial to mesenchymal transition 15448698 Process
2932 GO:0001954 IMP involved_in positive regulation of cell-matrix adhesion 18156211 Process
2932 GO:0005977 IDA involved_in glycogen metabolic process 8638126 Process
2932 GO:0006468 IDA involved_in protein phosphorylation 11035810,16315267,20937854 Process
2932 GO:0006468 IMP involved_in protein phosphorylation 16981698 Process
2932 GO:0006983 IDA acts_upstream_of_or_within ER overload response 14744935 Process
2932 GO:0010628 IMP acts_upstream_of positive regulation of gene expression 26315788,27050373 Process
2932 GO:0010629 IMP acts_upstream_of negative regulation of gene expression 27050373,28122350 Process
2932 GO:0010822 IMP involved_in positive regulation of mitochondrion organization 25118933 Process
2932 GO:0018105 IDA acts_upstream_of_or_within peptidyl-serine phosphorylation 11104755,14744935 Process
2932 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 8638126,11955436,17139249 Process
2932 GO:0018105 IGI involved_in peptidyl-serine phosphorylation 30556160 Process
2932 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 11955436,17139249,25897075 Process
2932 GO:0021766 IMP involved_in hippocampus development 19581563 Process
2932 GO:0031175 IDA involved_in neuron projection development 19830702 Process
2932 GO:0031333 IMP involved_in negative regulation of protein-containing complex assembly 16188939 Process
2932 GO:0031334 IDA involved_in positive regulation of protein-containing complex assembly 8638126 Process
2932 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 29142209 Process
2932 GO:0032091 IDA involved_in negative regulation of protein binding 16890161 Process
2932 GO:0032436 IDA involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 19364825,22660580 Process
2932 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 25897075 Process
2932 GO:0032886 IMP involved_in regulation of microtubule-based process 20937854 Process
2932 GO:0035556 IDA acts_upstream_of_or_within intracellular signal transduction 14749367 Process
2932 GO:0043066 IDA acts_upstream_of_or_within negative regulation of apoptotic process 14744935 Process
2932 GO:0043547 IMP involved_in positive regulation of GTPase activity 18156211 Process
2932 GO:0045597 IMP involved_in positive regulation of cell differentiation 28122350 Process
2932 GO:0046777 IDA involved_in protein autophosphorylation 23184662 Process
2932 GO:0046825 IDA involved_in regulation of protein export from nucleus 12223487 Process
2932 GO:0046827 IDA acts_upstream_of_or_within positive regulation of protein export from nucleus 14744935 Process
2932 GO:0070885 IMP involved_in negative regulation of calcineurin-NFAT signaling cascade 9072970 Process
2932 GO:0071109 IMP involved_in superior temporal gyrus development 19581563 Process
2932 GO:0071300 IMP involved_in cellular response to retinoic acid 28122350 Process
2932 GO:0090090 IGI involved_in negative regulation of canonical Wnt signaling pathway 27846906 Process
2932 GO:0099171 EXP involved_in presynaptic modulation of chemical synaptic transmission 17989287 Process
2932 GO:0099171 IDA involved_in presynaptic modulation of chemical synaptic transmission 17989287 Process
2932 GO:0099171 IMP involved_in presynaptic modulation of chemical synaptic transmission 17989287 Process
2932 GO:0150101 IMP involved_in regulation of microtubule anchoring at centrosome 17139249 Process
2932 GO:1902042 IMP involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 18846110 Process
2932 GO:1904781 IMP involved_in positive regulation of protein localization to centrosome 17139249 Process
2932 GO:1904886 IDA involved_in beta-catenin destruction complex disassembly 10428961 Process
2932 GO:1905240 IMP involved_in negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation 24023731 Process
2932 GO:2000740 IMP involved_in negative regulation of mesenchymal stem cell differentiation 24023731 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2932 GO:0002020 IPI enables protease binding 25118933 Function
2932 GO:0002039 IDA enables p53 binding 14744935 Function
2932 GO:0004672 IMP enables protein kinase activity 16981698 Function
2932 GO:0004674 IDA enables protein serine/threonine kinase activity 8638126,9072970,11035810,11104755,11955436,14744935,15448698,1..... Function
2932 GO:0004674 IMP enables protein serine/threonine kinase activity 16981698 Function
2932 GO:0005515 IPI enables protein binding 8638126,9482734,9601641,9731200,10481074,11004522,11035810,117..... Function
2932 GO:0008013 IPI enables beta-catenin binding 8638126 Function
2932 GO:0016301 IDA enables kinase activity 15448698,24391509 Function
2932 GO:0019901 IPI enables protein kinase binding 18348280 Function
2932 GO:0031625 IPI enables ubiquitin protein ligase binding 21118991 Function
2932 GO:0034236 IPI enables protein kinase A catalytic subunit binding 11035810 Function
2932 GO:0034452 IPI enables dynactin binding 17139249 Function
2932 GO:0050321 IDA enables tau-protein kinase activity 14690523,16365045 Function
2932 GO:0051059 IPI enables NF-kappaB binding 15465828 Function
2932 GO:0061629 IPI enables RNA polymerase II-specific DNA-binding transcription factor binding 20864106 Function
2932 GO:0106310 IGI enables protein serine kinase activity 30556160 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
2932 GO:0005634 IDA located_in nucleus 12223487,14744935,15448698 Component
2932 GO:0005654 IDA located_in nucleoplasm Component
2932 GO:0005737 IDA located_in cytoplasm 12223487,14744935,15448698,18787224,19038973,20937854..... Component
2932 GO:0005813 IDA located_in centrosome 17139249,21399614 Component
2932 GO:0005886 IDA located_in plasma membrane 20937854 Component
2932 GO:0030877 IDA part_of beta-catenin destruction complex 8638126,9601641,16188939 Component
2932 GO:0098978 EXP is_active_in glutamatergic synapse 17989287 Component
2932 GO:0098978 IDA is_active_in glutamatergic synapse 17989287 Component
2932 GO:0098978 IMP is_active_in glutamatergic synapse 17989287 Component