Gene Ontology

Gene Info

• Species:Human (Homo sapiens)
• GeneID:3066
• Symbol:HDAC2
• Description:histone deacetylase 2

Component

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3066	GO:0000118	IDA	part_of	histone deacetylase complex	9651585	Component
3066	GO:0000781	IDA	located_in	chromosome, telomeric region	25150861	Component
3066	GO:0000785	HDA	part_of	chromatin	16217013	Component
3066	GO:0005634	IDA	located_in	nucleus	18347167,20523938,24970816,33283408	Component
3066	GO:0005654	IDA	located_in	nucleoplasm		Component
3066	GO:0005737	IDA	located_in	cytoplasm	24970816	Component
3066	GO:0016580	IDA	part_of	Sin3 complex	14966270,17827154	Component
3066	GO:0016581	IDA	part_of	NuRD complex	17827154,19644445,22926524,33283408	Component
3066	GO:0032991	HDA	part_of	protein-containing complex	16217013	Component
3066	GO:0032991	IDA	part_of	protein-containing complex	28046085	Component
3066	GO:0035098	IDA	part_of	ESC/E(Z) complex	20075857	Component

Process

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3066	GO:0000122	IMP	involved_in	negative regulation of transcription by RNA polymerase II	19041327,19276356	Process
3066	GO:0006338	HDA	involved_in	chromatin remodeling	16217013	Process
3066	GO:0006338	IDA	involved_in	chromatin remodeling	9790534	Process
3066	GO:0008284	IMP	involved_in	positive regulation of cell population proliferation	18347167	Process
3066	GO:0016575	IDA	involved_in	histone deacetylation	10444591	Process
3066	GO:0016575	IMP	involved_in	histone deacetylation	19372552	Process
3066	GO:0043433	IMP	involved_in	negative regulation of DNA-binding transcription factor activity	19041327	Process
3066	GO:0045862	IMP	involved_in	positive regulation of proteolysis	19041327	Process
3066	GO:0045892	IMP	involved_in	negative regulation of DNA-templated transcription	19276356	Process
3066	GO:0045944	IMP	involved_in	positive regulation of transcription by RNA polymerase II	19041327,19372552	Process
3066	GO:0070828	IMP	involved_in	heterochromatin organization	19372552	Process
3066	GO:2000273	IMP	acts_upstream_of	positive regulation of signaling receptor activity	18316616	Process

Function

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GeneID	GO_ID	Evidence	Qualifier	GO_term	Pubmed ID	Category
3066	GO:0003723	HDA	enables	RNA binding	22681889	Function
3066	GO:0004407	IDA	enables	histone deacetylase activity	16642021,28497810	Function
3066	GO:0005515	IPI	enables	protein binding	9150135,11062478,11259576,11641274,11739383,12140263,12176973,.....	Function
3066	GO:0019899	IPI	enables	enzyme binding	11062478,11641274	Function
3066	GO:0031492	HDA	contributes_to	nucleosomal DNA binding	16217013	Function
3066	GO:0033558	IMP	enables	protein lysine deacetylase activity	19041327	Function
3066	GO:0042826	IPI	enables	histone deacetylase binding	28046085	Function
3066	GO:0043565	IDA	enables	sequence-specific DNA binding	19276356	Function
3066	GO:0051059	IPI	enables	NF-kappaB binding	17785205	Function
3066	GO:0061629	IPI	enables	RNA polymerase II-specific DNA-binding transcription factor binding	17827154,22926524	Function
3066	GO:0160009	IDA	enables	histone decrotonylase activity	28497810	Function
3066	GO:0160010	IDA	enables	protein de-2-hydroxyisobutyrylase activity	29192674	Function