Gene Ontology

Gene Info

  • Species:Fly (Drosophila melanogaster)
  • GeneID:31014
  • Symbol:Roc1a
  • Description:Regulator of cullins 1a

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
31014 GO:0005515 IPI enables protein binding 23747190 Function
31014 GO:0061630 IDA enables ubiquitin protein ligase activity 12062088,18698375 Function
31014 GO:0097602 IPI enables cullin family protein binding 11500045,18698375,26263855 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
31014 GO:0005634 IDA located_in nucleus 12062088 Component
31014 GO:0019005 IDA part_of SCF ubiquitin ligase complex 11500045,12062088,15331761,18698375,23747190,24068890..... Component
31014 GO:0019005 IMP part_of SCF ubiquitin ligase complex 22359584 Component
31014 GO:0031462 IDA part_of Cul2-RING ubiquitin ligase complex 15331761,18698375 Component
31014 GO:0031462 IPI part_of Cul2-RING ubiquitin ligase complex 30308158 Component
31014 GO:0031463 IDA part_of Cul3-RING ubiquitin ligase complex 18698375 Component
31014 GO:0080008 IDA part_of Cul4-RING E3 ubiquitin ligase complex 18698375 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
31014 GO:0006508 IMP involved_in proteolysis 12062088 Process
31014 GO:0008283 IMP involved_in cell population proliferation 12062088 Process
31014 GO:0016567 IDA involved_in protein ubiquitination 12062088,18698375 Process
31014 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 22359584 Process
31014 GO:0045879 IMP involved_in negative regulation of smoothened signaling pathway 12062088,15331761 Process
31014 GO:0046627 IPI involved_in negative regulation of insulin receptor signaling pathway 24068890 Process
31014 GO:0090090 IMP involved_in negative regulation of canonical Wnt signaling pathway 22359584 Process
31014 GO:1904801 IMP involved_in positive regulation of neuron remodeling 24068890 Process