Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3105
  • Symbol:HLA-A
  • Description:major histocompatibility complex, class I, A

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3105 GO:0001913 IDA involved_in T cell mediated cytotoxicity 7504010 Process
3105 GO:0001916 IDA involved_in positive regulation of T cell mediated cytotoxicity 2420472,8805302,22031944,25631937 Process
3105 GO:0002419 IDA involved_in T cell mediated cytotoxicity directed against tumor cell target 1402688,17189421,20364150 Process
3105 GO:0002485 IMP involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent 8630735 Process
3105 GO:0002486 IDA involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 22031944 Process
3105 GO:0002726 IDA involved_in positive regulation of T cell cytokine production 24643698 Process
3105 GO:0006955 IMP involved_in immune response 22321387 Process
3105 GO:0016045 IMP involved_in detection of bacterium 22321387 Process
3105 GO:0019731 IDA involved_in antibacterial humoral response 25631937 Process
3105 GO:0019885 IDA involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I 1402688,20364150,24643698 Process
3105 GO:0032729 IDA involved_in positive regulation of type II interferon production 22031944 Process
3105 GO:0036037 IDA involved_in CD8-positive, alpha-beta T cell activation 1402688,2784196,7504010,8630735,12138174,17189421,20364150..... Process
3105 GO:0042270 IDA NOT involved_in protection from natural killer cell mediated cytotoxicity 18502829 Process
3105 GO:0042270 IDA involved_in protection from natural killer cell mediated cytotoxicity 8839770,18502829 Process
3105 GO:0042590 IDA involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I 7504010,12138174 Process
3105 GO:0050830 IDA involved_in defense response to Gram-positive bacterium 25631937 Process
3105 GO:0050852 IDA involved_in T cell receptor signaling pathway 10435578 Process
3105 GO:2000566 IDA involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation 25631937 Process
3105 GO:2000568 IDA involved_in positive regulation of memory T cell activation 22031944 Process
3105 GO:2001187 IDA involved_in positive regulation of CD8-positive, alpha-beta T cell activation 24643698 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3105 GO:0003723 HDA enables RNA binding 22658674 Function
3105 GO:0005102 IPI enables signaling receptor binding 19124746 Function
3105 GO:0005515 IPI enables protein binding 9177355,12414957,20946353,23401559,26869717 Function
3105 GO:0030881 IDA enables beta-2-microglobulin binding 3309677,7694806,8805302,8906788 Function
3105 GO:0030881 IMP enables beta-2-microglobulin binding 23566939 Function
3105 GO:0042605 IDA enables peptide antigen binding 1402688,7504010,7694806,8805302,8839770,8906788,8955188,917735..... Function
3105 GO:0042605 IMP enables peptide antigen binding 23566939 Function
3105 GO:0042608 IDA enables T cell receptor binding 8906788,8955188,10435578 Function
3105 GO:0042610 IDA enables CD8 receptor binding 2784196 Function
3105 GO:0046977 IDA enables TAP binding 8617941,8805302 Function
3105 GO:0062061 IDA enables TAP complex binding 8630735 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3105 GO:0005783 IDA located_in endoplasmic reticulum 8805302,20946353 Component
3105 GO:0005794 IDA located_in Golgi apparatus 20946353 Component
3105 GO:0005797 IDA located_in Golgi medial cisterna 8805302 Component
3105 GO:0005886 IDA located_in plasma membrane 2784196,8630735 Component
3105 GO:0009986 IDA located_in cell surface 8805302,8839770,22031944 Component
3105 GO:0016020 HDA located_in membrane 19946888 Component
3105 GO:0042612 IDA part_of MHC class I protein complex 7694806,8805302,8906788,22031944,25631937 Component
3105 GO:0042824 IDA part_of MHC class I peptide loading complex 21263072 Component
3105 GO:0070062 HDA located_in extracellular exosome 11487543,19199708,20458337 Component
3105 GO:0070971 IDA located_in endoplasmic reticulum exit site 20946353 Component