Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:324
  • Symbol:APC
  • Description:APC regulator of WNT signaling pathway

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
324 GO:0000281 IMP acts_upstream_of_or_within mitotic cytokinesis 17570218 Process
324 GO:0006974 IDA involved_in DNA damage response 14728717 Process
324 GO:0007026 IDA involved_in negative regulation of microtubule depolymerization 11166179 Process
324 GO:0007026 IMP acts_upstream_of_or_within negative regulation of microtubule depolymerization 17192415 Process
324 GO:0007094 IMP acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling 17227893 Process
324 GO:0008285 IDA involved_in negative regulation of cell population proliferation 8521819 Process
324 GO:0016477 IMP involved_in cell migration 19151759 Process
324 GO:0030335 IMP acts_upstream_of_or_within positive regulation of cell migration 17192415 Process
324 GO:0031274 IMP acts_upstream_of_or_within positive regulation of pseudopodium assembly 17192415 Process
324 GO:0032886 IMP involved_in regulation of microtubule-based process 20937854 Process
324 GO:0043065 IMP acts_upstream_of_or_within positive regulation of apoptotic process 17227893 Process
324 GO:0045732 IGI acts_upstream_of_or_within positive regulation of protein catabolic process 12952940 Process
324 GO:0045736 IDA involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity 8521819 Process
324 GO:0051988 IMP acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore 17227893 Process
324 GO:0065003 IDA involved_in protein-containing complex assembly 16188939 Process
324 GO:0090090 IGI acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway 12952940 Process
324 GO:0090090 IGI involved_in negative regulation of canonical Wnt signaling pathway 21471006 Process
324 GO:0090090 IMP involved_in negative regulation of canonical Wnt signaling pathway 10656683,30374053 Process
324 GO:1902807 IDA involved_in negative regulation of cell cycle G1/S phase transition 8521819 Process
324 GO:1904781 IMP involved_in positive regulation of protein localization to centrosome 28057765 Process
324 GO:2000134 IMP involved_in negative regulation of G1/S transition of mitotic cell cycle 10656683 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
324 GO:0000776 IDA located_in kinetochore 11283619 Component
324 GO:0005634 IDA located_in nucleus 11035805,12072559,12955080 Component
324 GO:0005737 IDA located_in cytoplasm 11035805,12955080,20937854 Component
324 GO:0005794 IDA located_in Golgi apparatus Component
324 GO:0005813 IDA located_in centrosome 11283619 Component
324 GO:0005874 IDA colocalizes_with microtubule 28057765 Component
324 GO:0005886 IDA colocalizes_with plasma membrane 16611247 Component
324 GO:0005886 IDA located_in plasma membrane 20937854 Component
324 GO:0005912 IDA colocalizes_with adherens junction 16611247 Component
324 GO:0005923 IDA located_in bicellular tight junction 18502210 Component
324 GO:0016328 IDA located_in lateral plasma membrane 12072559 Component
324 GO:0016342 IDA part_of catenin complex 7806582 Component
324 GO:0030027 IDA located_in lamellipodium 19151759 Component
324 GO:0030877 IDA part_of beta-catenin destruction complex 8638126,9601641,16188939 Component
324 GO:0032587 IDA located_in ruffle membrane 19151759 Component
324 GO:0048471 IDA located_in perinuclear region of cytoplasm 18076571 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
324 GO:0005515 IPI enables protein binding 8638125,8638126,9601641,9707618,10811618,10947987,11283619,113..... Function
324 GO:0008013 EXP enables beta-catenin binding 15327768 Function
324 GO:0008013 IDA enables beta-catenin binding 7806582 Function
324 GO:0008013 IPI enables beta-catenin binding 7890674,9707618,10773885,11533658,15327768,16753179..... Function
324 GO:0008017 IDA enables microtubule binding 11166179,16188939 Function
324 GO:0019887 IDA enables protein kinase regulator activity 11972058 Function
324 GO:0019901 IDA enables protein kinase binding 24130866 Function
324 GO:0019901 IPI enables protein kinase binding 8638126 Function
324 GO:0031625 IDA enables ubiquitin protein ligase binding 18076571 Function
324 GO:0045295 IPI enables gamma-catenin binding 7890674 Function
324 GO:0045296 IDA NOT enables cadherin binding 7890674 Function
324 GO:0051010 IDA enables microtubule plus-end binding 19632184 Function
324 GO:0070840 IPI enables dynein complex binding 28057765 Function