Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3383
  • Symbol:ICAM1
  • Description:intercellular adhesion molecule 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3383 GO:0002291 IMP involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2477710 Process
3383 GO:0002693 IMP involved_in positive regulation of cellular extravasation 12902516 Process
3383 GO:0007155 IDA involved_in cell adhesion 16809613 Process
3383 GO:0007159 IMP involved_in leukocyte cell-cell adhesion 2477710 Process
3383 GO:0022614 IEP involved_in membrane to membrane docking 12082081 Process
3383 GO:0044406 IDA involved_in adhesion of symbiont to host 2538243 Process
3383 GO:0046813 IDA involved_in receptor-mediated virion attachment to host cell 2538243 Process
3383 GO:0050900 IEP involved_in leukocyte migration 12082081 Process
3383 GO:0061028 IGI involved_in establishment of endothelial barrier 23264465 Process
3383 GO:0070374 IMP involved_in positive regulation of ERK1 and ERK2 cascade 10903502 Process
3383 GO:1902042 IDA involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 10903502 Process
3383 GO:1904646 IDA involved_in cellular response to amyloid-beta 11078691 Process
3383 GO:2000352 IDA involved_in negative regulation of endothelial cell apoptotic process 10903502 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3383 GO:0005178 IDA enables integrin binding 23620790 Function
3383 GO:0005178 IPI enables integrin binding 1448173,12208882 Function
3383 GO:0005515 IPI enables protein binding 7822297,12526797,12716892,16595626,22956999,23858057,32296183,..... Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3383 GO:0005615 IDA located_in extracellular space 9290466 Component
3383 GO:0005925 HDA located_in focal adhesion 21423176 Component
3383 GO:0009986 HDA located_in cell surface 19581412,23981064 Component
3383 GO:0016020 HDA located_in membrane 19946888 Component
3383 GO:0062023 HDA located_in collagen-containing extracellular matrix 27559042 Component
3383 GO:0070062 HDA located_in extracellular exosome 19056867,20458337 Component
3383 GO:0070062 IDA located_in extracellular exosome 21276792 Component