Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3551
  • Symbol:IKBKB
  • Description:inhibitor of nuclear factor kappa B kinase subunit beta

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3551 GO:0004672 IDA enables protein kinase activity 20434986 Function
3551 GO:0004674 EXP enables protein serine/threonine kinase activity 18692471,23613522 Function
3551 GO:0004674 IDA enables protein serine/threonine kinase activity 14673179,15084260,25326418,25636800 Function
3551 GO:0005515 IPI enables protein binding 9520446,9751060,10521409,10733566,11297557,11971985,12482991,1..... Function
3551 GO:0008384 IDA enables IkappaB kinase activity 9346484 Function
3551 GO:0019901 IPI enables protein kinase binding 12492477 Function
3551 GO:0042802 IPI enables identical protein binding 16319058,21423167,23776406 Function
3551 GO:0042803 IDA enables protein homodimerization activity 23091055 Function
3551 GO:0046982 IDA enables protein heterodimerization activity 23091055 Function
3551 GO:0097110 IDA enables scaffold protein binding 23776175 Function
3551 GO:1990459 IPI enables transferrin receptor binding 23016877 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3551 GO:0005737 IDA is_active_in cytoplasm 9804806 Component
3551 GO:0005829 IDA located_in cytosol Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3551 GO:0006468 IDA involved_in protein phosphorylation 15084260,20434986 Process
3551 GO:0007249 IDA involved_in I-kappaB kinase/NF-kappaB signaling 9346484 Process
3551 GO:0007249 IMP involved_in I-kappaB kinase/NF-kappaB signaling 15383541,25816133 Process
3551 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 21399639,25326418 Process
3551 GO:0030866 IMP involved_in cortical actin cytoskeleton organization 25816133 Process
3551 GO:0033209 IMP involved_in tumor necrosis factor-mediated signaling pathway 15084260,25816133 Process
3551 GO:0035509 IMP involved_in negative regulation of myosin-light-chain-phosphatase activity 25816133 Process
3551 GO:0042325 IDA involved_in regulation of phosphorylation 26212789 Process
3551 GO:0043123 IMP involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling 30337470 Process
3551 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 23091055,23453807 Process
3551 GO:0051092 IDA acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity 15790681 Process
3551 GO:0070498 IMP involved_in interleukin-1-mediated signaling pathway 25816133 Process
3551 GO:0071356 IDA involved_in cellular response to tumor necrosis factor 23091055 Process
3551 GO:0072659 IMP involved_in protein localization to plasma membrane 25816133 Process
3551 GO:1903140 IMP involved_in regulation of establishment of endothelial barrier 25816133 Process
3551 GO:1903347 IMP involved_in negative regulation of bicellular tight junction assembly 25816133 Process