Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3716
  • Symbol:JAK1
  • Description:Janus kinase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3716 GO:0004713 EXP enables protein tyrosine kinase activity 1386289,10825200,31892268 Function
3716 GO:0004713 IDA enables protein tyrosine kinase activity 7532278,7929391,7973659,8272873,8756628 Function
3716 GO:0004715 IDA enables non-membrane spanning protein tyrosine kinase activity 7657660,8232552 Function
3716 GO:0005515 IPI enables protein binding 7759950,16273093,16710296,21220115,21679692,25065853,26175413,..... Function
3716 GO:0019903 IPI enables protein phosphatase binding 11909529 Function
3716 GO:0031625 IPI enables ubiquitin protein ligase binding 24882218 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3716 GO:0005634 IDA located_in nucleus 10502458 Component
3716 GO:0005737 IDA located_in cytoplasm 10502458 Component
3716 GO:0005925 HDA located_in focal adhesion 21423176 Component
3716 GO:0009898 IDA is_active_in cytoplasmic side of plasma membrane 8272873 Component
3716 GO:0031234 IDA is_active_in extrinsic component of cytoplasmic side of plasma membrane 7973659 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3716 GO:0006468 IMP involved_in protein phosphorylation 28111307,32750333 Process
3716 GO:0007259 IDA involved_in receptor signaling pathway via JAK-STAT 7657660,8232552,8272873 Process
3716 GO:0007259 IMP involved_in receptor signaling pathway via JAK-STAT 28111307,32750333 Process
3716 GO:0034112 IMP involved_in positive regulation of homotypic cell-cell adhesion 21679692 Process
3716 GO:0035723 IDA involved_in interleukin-15-mediated signaling pathway 7568001 Process
3716 GO:0035771 IDA involved_in interleukin-4-mediated signaling pathway 7929391 Process
3716 GO:0038110 IDA involved_in interleukin-2-mediated signaling pathway 7973659,11909529 Process
3716 GO:0038113 IDA involved_in interleukin-9-mediated signaling pathway 8756628 Process
3716 GO:0038154 IDA involved_in interleukin-11-mediated signaling pathway 8272872 Process
3716 GO:0046677 IDA acts_upstream_of_or_within response to antibiotic 16280321 Process
3716 GO:0060333 IDA involved_in type II interferon-mediated signaling pathway 8232552 Process
3716 GO:0060337 IDA involved_in type I interferon-mediated signaling pathway 7532278,8232552 Process
3716 GO:0070102 IDA involved_in interleukin-6-mediated signaling pathway 8272873 Process
3716 GO:0150105 IMP involved_in protein localization to cell-cell junction 21679692 Process
3716 GO:1900182 IDA involved_in positive regulation of protein localization to nucleus 26479788 Process
3716 GO:1903672 IGI involved_in positive regulation of sprouting angiogenesis 20299512 Process