Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3717
  • Symbol:JAK2
  • Description:Janus kinase 2

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3717 GO:0004713 EXP enables protein tyrosine kinase activity 9111318,15143187,19665053,20304997 Function
3717 GO:0004713 IDA enables protein tyrosine kinase activity 8007942,23061660 Function
3717 GO:0005102 IPI enables signaling receptor binding 11201744 Function
3717 GO:0005515 IPI enables protein binding 9516124,11679576,11694501,11970898,15821101,16437163,17474147,..... Function
3717 GO:0019901 IDA enables protein kinase binding 10925297 Function
3717 GO:0020037 IDA enables heme binding 21036157 Function
3717 GO:0035401 IDA enables histone H3Y41 kinase activity 19783980 Function
3717 GO:0042169 IPI enables SH2 domain binding 9727029 Function
3717 GO:0042393 IDA enables histone binding 19783980 Function
3717 GO:0042802 IPI enables identical protein binding 21841788,22820988 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3717 GO:0005634 IDA located_in nucleus 10502458,19783980 Component
3717 GO:0005654 IDA located_in nucleoplasm Component
3717 GO:0005737 IDA located_in cytoplasm 10502458 Component
3717 GO:0005886 IDA located_in plasma membrane Component
3717 GO:0005925 IDA located_in focal adhesion Component
3717 GO:0019897 IDA is_active_in extrinsic component of plasma membrane 8007942 Component
3717 GO:0030526 IDA part_of granulocyte macrophage colony-stimulating factor receptor complex 27396825 Component
3717 GO:0031234 IDA is_active_in extrinsic component of cytoplasmic side of plasma membrane 8007942 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3717 GO:0006468 IDA involved_in protein phosphorylation 18692472 Process
3717 GO:0007259 IDA involved_in receptor signaling pathway via JAK-STAT 18692472,31145836 Process
3717 GO:0010572 IDA acts_upstream_of_or_within positive regulation of platelet activation 31145836 Process
3717 GO:0010811 IDA involved_in positive regulation of cell-substrate adhesion 10925297 Process
3717 GO:0019221 IDA involved_in cytokine-mediated signaling pathway 8609418 Process
3717 GO:0032729 IDA involved_in positive regulation of type II interferon production 12023369,19088061 Process
3717 GO:0032819 IDA involved_in positive regulation of natural killer cell proliferation 19088061 Process
3717 GO:0033209 IDA involved_in tumor necrosis factor-mediated signaling pathway 8609418 Process
3717 GO:0034612 IDA involved_in response to tumor necrosis factor 8609418 Process
3717 GO:0035722 IDA involved_in interleukin-12-mediated signaling pathway 7528775 Process
3717 GO:0038043 IDA involved_in interleukin-5-mediated signaling pathway 7613138 Process
3717 GO:0038065 IMP involved_in collagen-activated signaling pathway 31145836 Process
3717 GO:0038156 IDA involved_in interleukin-3-mediated signaling pathway 8007942 Process
3717 GO:0038157 IDA involved_in granulocyte-macrophage colony-stimulating factor signaling pathway 18692472 Process
3717 GO:0042102 IDA involved_in positive regulation of T cell proliferation 11114383 Process
3717 GO:0043687 IDA involved_in post-translational protein modification 19783980 Process
3717 GO:0046427 IDA involved_in positive regulation of receptor signaling pathway via JAK-STAT 7638186,12023369 Process
3717 GO:0046677 IDA acts_upstream_of_or_within response to antibiotic 16280321 Process
3717 GO:0050727 IDA involved_in regulation of inflammatory response 10925297 Process
3717 GO:0051142 IDA involved_in positive regulation of NK T cell proliferation 19088061 Process
3717 GO:0060391 IGI acts_upstream_of_or_within positive regulation of SMAD protein signal transduction 28334068 Process
3717 GO:0060396 IDA involved_in growth hormone receptor signaling pathway 10925297 Process
3717 GO:0070665 IDA involved_in positive regulation of leukocyte proliferation 18692472 Process
3717 GO:0070671 IDA involved_in response to interleukin-12 7528775 Process
3717 GO:1901731 IDA acts_upstream_of positive regulation of platelet aggregation 31145836 Process