Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:3949
  • Symbol:LDLR
  • Description:low density lipoprotein receptor

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3949 GO:0001920 IDA involved_in negative regulation of receptor recycling 17452316 Process
3949 GO:0007616 IGI involved_in long-term memory 24412220 Process
3949 GO:0010989 IDA involved_in negative regulation of low-density lipoprotein particle clearance 17452316 Process
3949 GO:0030299 IMP involved_in intestinal cholesterol absorption 17142622 Process
3949 GO:0030301 IMP involved_in cholesterol transport 17142622 Process
3949 GO:0034383 IMP involved_in low-density lipoprotein particle clearance 6299582,17142622 Process
3949 GO:0042632 IGI involved_in cholesterol homeostasis 24412220 Process
3949 GO:0042632 IMP involved_in cholesterol homeostasis 6299582,17142622 Process
3949 GO:0051246 IGI involved_in regulation of protein metabolic process 24412220 Process
3949 GO:0061771 IGI involved_in response to caloric restriction 24412220 Process
3949 GO:0070508 IMP involved_in cholesterol import 6299582 Process
3949 GO:0071404 IMP involved_in cellular response to low-density lipoprotein particle stimulus 6299582 Process
3949 GO:0090118 IMP involved_in receptor-mediated endocytosis involved in cholesterol transport 6299582 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3949 GO:0002020 IPI enables protease binding 22081141,22848640 Function
3949 GO:0005041 IDA enables low-density lipoprotein particle receptor activity 6091915,8626535 Function
3949 GO:0005041 IMP enables low-density lipoprotein particle receptor activity 6299582 Function
3949 GO:0005515 IPI enables protein binding 10571240,12221107,17452316,17461796,18250299,18753623,20030366..... Function
3949 GO:0030169 IMP enables low-density lipoprotein particle binding 6299582 Function
3949 GO:0030229 IDA enables very-low-density lipoprotein particle receptor activity 8626535 Function
3949 GO:0042802 IPI enables identical protein binding 26526611 Function
3949 GO:0060090 EXP enables molecular adaptor activity 22091758 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
3949 GO:0005764 IDA located_in lysosome 15166224,17461796 Component
3949 GO:0005769 IDA located_in early endosome 15166224,17461796 Component
3949 GO:0005770 IDA located_in late endosome 17461796 Component
3949 GO:0005794 IDA located_in Golgi apparatus 17461796 Component
3949 GO:0005905 IDA located_in clathrin-coated pit 6091915,15166224 Component
3949 GO:0009897 IDA located_in external side of plasma membrane 15166224 Component
3949 GO:0009986 IDA located_in cell surface 17461796 Component
3949 GO:0016020 HDA located_in membrane 19946888 Component
3949 GO:0043235 IDA part_of receptor complex 23382219 Component
3949 GO:1990666 IDA part_of PCSK9-LDLR complex 22081141,22848640 Component
3949 GO:1990666 IPI part_of PCSK9-LDLR complex 22081141 Component