Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4040
  • Symbol:LRP6
  • Description:LDL receptor related protein 6

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4040 GO:0001933 IMP involved_in negative regulation of protein phosphorylation 16365045 Process
4040 GO:0006469 IMP involved_in negative regulation of protein kinase activity 16365045 Process
4040 GO:0014029 IDA involved_in neural crest formation 11029007 Process
4040 GO:0014033 IDA involved_in neural crest cell differentiation 11029007 Process
4040 GO:0016055 IDA involved_in Wnt signaling pathway 11357136 Process
4040 GO:0034392 IMP involved_in negative regulation of smooth muscle cell apoptotic process 15271658 Process
4040 GO:0045787 IMP involved_in positive regulation of cell cycle 15271658 Process
4040 GO:0045893 IMP involved_in positive regulation of DNA-templated transcription 18215320 Process
4040 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 12857724 Process
4040 GO:0051091 IDA involved_in positive regulation of DNA-binding transcription factor activity 14739301 Process
4040 GO:0060070 IDA acts_upstream_of_or_within canonical Wnt signaling pathway 16263759,16543246 Process
4040 GO:0060070 IDA involved_in canonical Wnt signaling pathway 11448771,11742004,12121999,14739301,15271658,15908424,17239604..... Process
4040 GO:0060070 IGI involved_in canonical Wnt signaling pathway 16805831 Process
4040 GO:0060070 IMP involved_in canonical Wnt signaling pathway 11029007,18215320,20093472 Process
4040 GO:0071397 IMP involved_in cellular response to cholesterol 16890161 Process
4040 GO:0071901 IDA involved_in negative regulation of protein serine/threonine kinase activity 19107203 Process
4040 GO:0072659 IPI involved_in protein localization to plasma membrane 22899650 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4040 GO:0005041 IDA enables low-density lipoprotein particle receptor activity 16263759 Function
4040 GO:0005102 IPI enables signaling receptor binding 14739301 Function
4040 GO:0005109 IPI enables frizzled binding 11029007 Function
4040 GO:0005515 IPI enables protein binding 11029007,11357136,11433302,11448771,12897152,15908424,16365045..... Function
4040 GO:0017147 IPI enables Wnt-protein binding 11029007,12897152,20093360 Function
4040 GO:0019210 IMP enables kinase inhibitor activity 16365045 Function
4040 GO:0019534 IMP NOT enables toxin transmembrane transporter activity 18350154 Function
4040 GO:0019534 IMP enables toxin transmembrane transporter activity 16564009 Function
4040 GO:0042802 IPI enables identical protein binding 12897152,21984209 Function
4040 GO:0042803 IPI enables protein homodimerization activity 12897152 Function
4040 GO:0071936 IDA enables coreceptor activity involved in Wnt signaling pathway 11029007 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4040 GO:0005769 IDA colocalizes_with early endosome 16890161 Component
4040 GO:0005794 IDA colocalizes_with Golgi apparatus 16890161 Component
4040 GO:0005886 IDA located_in plasma membrane 16263759,16890161,17569865 Component
4040 GO:0005901 IDA colocalizes_with caveola 16890161,17569865 Component
4040 GO:0009986 IDA located_in cell surface 12897152 Component
4040 GO:0031410 IDA located_in cytoplasmic vesicle 16890161,20093472 Component
4040 GO:1990851 IDA part_of Wnt-Frizzled-LRP5/6 complex 20093360 Component
4040 GO:1990851 IPI part_of Wnt-Frizzled-LRP5/6 complex 11029007,11448771 Component
4040 GO:1990909 IDA part_of Wnt signalosome 22899650 Component