Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4067
  • Symbol:LYN
  • Description:LYN proto-oncogene, Src family tyrosine kinase

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4067 GO:0001934 IGI involved_in positive regulation of protein phosphorylation 24217950 Process
4067 GO:0002244 IMP involved_in hematopoietic progenitor cell differentiation 16467205 Process
4067 GO:0006468 IDA involved_in protein phosphorylation 11517336 Process
4067 GO:0006974 IDA involved_in DNA damage response 10891478,11517336 Process
4067 GO:0007169 IMP involved_in transmembrane receptor protein tyrosine kinase signaling pathway 14726379 Process
4067 GO:0008285 IMP involved_in negative regulation of cell population proliferation 14726379 Process
4067 GO:0010976 IMP involved_in positive regulation of neuron projection development 17910947 Process
4067 GO:0018108 IDA involved_in peptidyl-tyrosine phosphorylation 7682714,11782428 Process
4067 GO:0030222 IDA involved_in eosinophil differentiation 11823534 Process
4067 GO:0033628 IMP involved_in regulation of cell adhesion mediated by integrin 18802065 Process
4067 GO:0038043 IDA involved_in interleukin-5-mediated signaling pathway 11823534 Process
4067 GO:0038159 IMP involved_in C-X-C chemokine receptor CXCR4 signaling pathway 16467205 Process
4067 GO:0046777 IDA involved_in protein autophosphorylation 7682714 Process
4067 GO:0070304 IDA involved_in positive regulation of stress-activated protein kinase signaling cascade 10891478 Process
4067 GO:0070668 IMP involved_in positive regulation of mast cell proliferation 11435302 Process
4067 GO:0071300 IMP involved_in cellular response to retinoic acid 17910947 Process
4067 GO:0090025 IMP involved_in regulation of monocyte chemotaxis 18802065 Process
4067 GO:1902961 IMP involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 24217950 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4067 GO:0004713 EXP enables protein tyrosine kinase activity 1381360,7526393,9799234,10861086,11110698,11358993,11448999,12..... Function
4067 GO:0004713 IDA enables protein tyrosine kinase activity 7682714,10748115,11823534,32958780 Function
4067 GO:0004715 IMP enables non-membrane spanning protein tyrosine kinase activity 23555801 Function
4067 GO:0005515 IPI enables protein binding 1715582,7859737,8647200,8753773,9020138,11306681,11517336,1178..... Function
4067 GO:0044325 IPI enables transmembrane transporter binding 12538589 Function
4067 GO:0046875 IPI enables ephrin receptor binding 24217950 Function
4067 GO:0097110 IPI enables scaffold protein binding 23555801 Function
4067 GO:0140031 IPI enables phosphorylation-dependent protein binding 11782428 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4067 GO:0005634 IDA located_in nucleus 18817770 Component
4067 GO:0005794 IDA located_in Golgi apparatus 15173188,20605918 Component
4067 GO:0005886 IDA located_in plasma membrane 15173188,20605918 Component
4067 GO:0009898 IDA is_active_in cytoplasmic side of plasma membrane 11823534 Component
4067 GO:0009986 IDA is_active_in cell surface 32958780 Component
4067 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component
4067 GO:0045121 IDA located_in membrane raft 11313396 Component
4067 GO:0048471 IDA located_in perinuclear region of cytoplasm 20605918 Component
4067 GO:0070062 HDA located_in extracellular exosome 23533145 Component