Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4086
  • Symbol:SMAD1
  • Description:SMAD family member 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4086 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 12270938,20147459 Function
4086 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 12270938 Function
4086 GO:0003700 IDA enables DNA-binding transcription factor activity 9389648 Function
4086 GO:0005515 IPI enables protein binding 9436979,11278251,11779505,15231748,15647271,15781469,16882717,..... Function
4086 GO:0017151 IPI enables DEAD/H-box RNA helicase binding 18548003 Function
4086 GO:0019901 IPI enables protein kinase binding 12874272 Function
4086 GO:0042802 IPI enables identical protein binding 9111321,11779505,15231748 Function
4086 GO:0070410 IPI enables co-SMAD binding 9111321 Function
4086 GO:0070411 IPI enables I-SMAD binding 9436979 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4086 GO:0001503 IGI involved_in ossification 25012146 Process
4086 GO:0006351 IDA involved_in DNA-templated transcription 11779505 Process
4086 GO:0007179 IDA involved_in transforming growth factor beta receptor signaling pathway 9389648 Process
4086 GO:0010628 IDA involved_in positive regulation of gene expression 19664780 Process
4086 GO:0030509 IDA involved_in BMP signaling pathway 8637600,8653785,9389648,18548003 Process
4086 GO:0030509 IMP involved_in BMP signaling pathway 19664780 Process
4086 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 12270938 Process
4086 GO:0060395 IGI involved_in SMAD protein signal transduction 25012146 Process
4086 GO:1903672 IMP involved_in positive regulation of sprouting angiogenesis 24047927 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4086 GO:0005634 IDA located_in nucleus 8653785,9389648 Component
4086 GO:0005637 IDA located_in nuclear inner membrane 15647271 Component
4086 GO:0005737 IDA located_in cytoplasm 9389648 Component
4086 GO:0032991 IDA part_of protein-containing complex 23610558 Component
4086 GO:0071142 IPI part_of homomeric SMAD protein complex 11779505 Component
4086 GO:0071144 IPI part_of heteromeric SMAD protein complex 11779505 Component