Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4089
  • Symbol:SMAD4
  • Description:SMAD family member 4

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4089 GO:0000785 IDA part_of chromatin 21828274 Component
4089 GO:0005634 IDA located_in nucleus 9311995,9389648,12161428,16007207 Component
4089 GO:0005654 IDA located_in nucleoplasm Component
4089 GO:0005667 IDA part_of transcription regulator complex 17438144 Component
4089 GO:0005667 IPI part_of transcription regulator complex 12374795 Component
4089 GO:0005737 IDA located_in cytoplasm 9311995,9389648,12161428 Component
4089 GO:0005813 IDA located_in centrosome Component
4089 GO:0005829 IDA located_in cytosol Component
4089 GO:0032444 IDA part_of activin responsive factor complex 9389648 Component
4089 GO:0071141 IDA part_of SMAD protein complex 18832382 Component
4089 GO:0071141 IMP part_of SMAD protein complex 10647180 Component
4089 GO:0071144 IPI part_of heteromeric SMAD protein complex 11779505,15350224 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4089 GO:0000976 IDA enables transcription cis-regulatory region binding 17438144 Function
4089 GO:0000978 IDA enables RNA polymerase II cis-regulatory region sequence-specific DNA binding 9389648,18832382,31582430 Function
4089 GO:0001223 IPI enables transcription coactivator binding 16777850 Function
4089 GO:0001228 IDA enables DNA-binding transcription activator activity, RNA polymerase II-specific 9389648,18832382 Function
4089 GO:0003677 IDA contributes_to DNA binding 9389648 Function
4089 GO:0003700 IDA contributes_to DNA-binding transcription factor activity 10823886,17438144 Function
4089 GO:0005515 IPI enables protein binding 9389648,9436979,9707553,11278302,11779505,12419246,14525983,14..... Function
4089 GO:0042802 IPI enables identical protein binding 9111321,10647180,21988832,25609649 Function
4089 GO:0042803 IPI enables protein homodimerization activity 8774881 Function
4089 GO:0043199 IMP enables sulfate binding 10647180 Function
4089 GO:0043565 IDA contributes_to sequence-specific DNA binding 10823886 Function
4089 GO:0070411 IPI enables I-SMAD binding 9256479 Function
4089 GO:0070412 IPI enables R-SMAD binding 8774881,9111321,9311995,9732876 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4089 GO:0001666 IMP involved_in response to hypoxia 12411310 Process
4089 GO:0001837 IMP involved_in epithelial to mesenchymal transition 30741461 Process
4089 GO:0006351 IDA involved_in DNA-templated transcription 11779505 Process
4089 GO:0007179 IDA involved_in transforming growth factor beta receptor signaling pathway 9389648,9732876 Process
4089 GO:0007179 IMP involved_in transforming growth factor beta receptor signaling pathway 25514493 Process
4089 GO:0010631 IMP involved_in epithelial cell migration 30741461 Process
4089 GO:0017015 IMP involved_in regulation of transforming growth factor beta receptor signaling pathway 8774881 Process
4089 GO:0030308 IDA involved_in negative regulation of cell growth 8774881 Process
4089 GO:0030509 IDA involved_in BMP signaling pathway 8637600,9389648 Process
4089 GO:0030511 IDA involved_in positive regulation of transforming growth factor beta receptor signaling pathway 19328798 Process
4089 GO:0030513 IMP involved_in positive regulation of BMP signaling pathway 19366699 Process
4089 GO:0032909 IMP involved_in regulation of transforming growth factor beta2 production 12411310 Process
4089 GO:0035556 IMP involved_in intracellular signal transduction 22316667 Process
4089 GO:0045892 IDA involved_in negative regulation of DNA-templated transcription 8774881 Process
4089 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 8774881,9311995,9389648,9707553,9732876 Process
4089 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 9389648,18832382 Process
4089 GO:0060395 IDA involved_in SMAD protein signal transduction 9707553,9732876 Process
4089 GO:0071559 IDA involved_in response to transforming growth factor beta 9707553 Process