Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4091
  • Symbol:SMAD6
  • Description:SMAD family member 6

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4091 GO:0000976 IDA enables transcription cis-regulatory region binding 16491121 Function
4091 GO:0003682 IDA enables chromatin binding 16491121 Function
4091 GO:0005515 IPI enables protein binding 9436979,16299379,16491121 Function
4091 GO:0031625 IPI enables ubiquitin protein ligase binding 11278251 Function
4091 GO:0034713 IDA enables type I transforming growth factor beta receptor binding 9436979 Function
4091 GO:0042802 IPI enables identical protein binding 9436979 Function
4091 GO:0070410 IPI enables co-SMAD binding 9256479 Function
4091 GO:0070411 IPI enables I-SMAD binding 9256479 Function
4091 GO:0070412 IPI enables R-SMAD binding 9256479,9436979 Function
4091 GO:0070698 IDA enables type I activin receptor binding 9436979 Function
4091 GO:0140416 IDA enables transcription regulator inhibitor activity 9256479 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4091 GO:0003180 IMP involved_in aortic valve morphogenesis 22275001 Process
4091 GO:0006955 IMP involved_in immune response 16886151 Process
4091 GO:0007352 IMP involved_in zygotic specification of dorsal/ventral axis 9436979 Process
4091 GO:0008285 IMP involved_in negative regulation of cell population proliferation 19047146 Process
4091 GO:0030509 IDA involved_in BMP signaling pathway 23455153 Process
4091 GO:0030512 IDA involved_in negative regulation of transforming growth factor beta receptor signaling pathway 9256479 Process
4091 GO:0030512 IMP involved_in negative regulation of transforming growth factor beta receptor signaling pathway 19047146 Process
4091 GO:0030514 IDA involved_in negative regulation of BMP signaling pathway 9436979 Process
4091 GO:0030514 IMP involved_in negative regulation of BMP signaling pathway 22275001,30848080 Process
4091 GO:0031589 IMP involved_in cell-substrate adhesion 16491121 Process
4091 GO:0032496 IDA involved_in response to lipopolysaccharide 19193853 Process
4091 GO:0034616 IEP involved_in response to laminar fluid shear stress 9256479 Process
4091 GO:0043066 IMP involved_in negative regulation of apoptotic process 19047146 Process
4091 GO:0045444 IDA involved_in fat cell differentiation 23455153 Process
4091 GO:0045668 IMP involved_in negative regulation of osteoblast differentiation 22275001 Process
4091 GO:0060394 IDA involved_in negative regulation of pathway-restricted SMAD protein phosphorylation 9436979 Process
4091 GO:0060394 IMP involved_in negative regulation of pathway-restricted SMAD protein phosphorylation 19047146 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4091 GO:0005634 IDA located_in nucleus 16491121 Component
4091 GO:0005654 IDA located_in nucleoplasm Component
4091 GO:0005794 IDA located_in Golgi apparatus Component
4091 GO:0005829 IDA located_in cytosol Component
4091 GO:0016604 IDA located_in nuclear body Component
4091 GO:0032991 IDA part_of protein-containing complex 23610558 Component