Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4092
  • Symbol:SMAD7
  • Description:SMAD family member 7

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4092 GO:0000122 IDA involved_in negative regulation of transcription by RNA polymerase II 17438144 Process
4092 GO:0010717 IMP involved_in regulation of epithelial to mesenchymal transition 24887517 Process
4092 GO:0010801 IDA involved_in negative regulation of peptidyl-threonine phosphorylation 18593713 Process
4092 GO:0010944 IDA involved_in negative regulation of transcription by competitive promoter binding 17438144 Process
4092 GO:0022409 IDA involved_in positive regulation of cell-cell adhesion 18593713 Process
4092 GO:0030512 IDA involved_in negative regulation of transforming growth factor beta receptor signaling pathway 9256479,12151385,17438144,18762808 Process
4092 GO:0030514 IDA involved_in negative regulation of BMP signaling pathway 17438144 Process
4092 GO:0031397 IDA involved_in negative regulation of protein ubiquitination 18593713 Process
4092 GO:0031398 IDA involved_in positive regulation of protein ubiquitination 16720724 Process
4092 GO:0031503 IDA involved_in protein-containing complex localization 18593713 Process
4092 GO:0032436 IDA involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 11278251 Process
4092 GO:0032925 IDA involved_in regulation of activin receptor signaling pathway 16720724 Process
4092 GO:0033137 IDA involved_in negative regulation of peptidyl-serine phosphorylation 18593713 Process
4092 GO:0034333 IMP involved_in adherens junction assembly 18593713 Process
4092 GO:0034616 IEP involved_in response to laminar fluid shear stress 9256479 Process
4092 GO:0043433 IDA involved_in negative regulation of DNA-binding transcription factor activity 17438144 Process
4092 GO:0050821 IDA involved_in protein stabilization 18593713 Process
4092 GO:0051444 IDA involved_in negative regulation of ubiquitin-protein transferase activity 18593713 Process
4092 GO:0060394 IDA involved_in negative regulation of pathway-restricted SMAD protein phosphorylation 17438144 Process
4092 GO:0071560 IMP involved_in cellular response to transforming growth factor beta stimulus 18593713 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4092 GO:0001650 IDA located_in fibrillar center Component
4092 GO:0005634 IDA located_in nucleus 11278251,12151385,17438144 Component
4092 GO:0005654 IDA located_in nucleoplasm Component
4092 GO:0005737 IDA located_in cytoplasm 11278251,17438144 Component
4092 GO:0005813 IDA located_in centrosome Component
4092 GO:0005829 IDA located_in cytosol Component
4092 GO:0005886 IDA located_in plasma membrane 12151385 Component
4092 GO:0005912 IDA colocalizes_with adherens junction 18593713 Component
4092 GO:0032991 IDA part_of protein-containing complex 23610558 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4092 GO:0005515 IPI enables protein binding 14993265,15231748,16601693,16720724,18593713,18762808,20937913..... Function
4092 GO:0008013 IPI enables beta-catenin binding 18593713 Function
4092 GO:0031625 IPI enables ubiquitin protein ligase binding 12151385 Function
4092 GO:0034713 IPI enables type I transforming growth factor beta receptor binding 11278251 Function
4092 GO:0048185 IPI enables activin binding 16720724 Function
4092 GO:0070411 IPI enables I-SMAD binding 9256479 Function
4092 GO:0140416 IDA enables transcription regulator inhibitor activity 9256479 Function