Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4217
  • Symbol:MAP3K5
  • Description:mitogen-activated protein kinase kinase kinase 5

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4217 GO:0000165 IDA involved_in MAPK cascade 17210579,21771788 Process
4217 GO:0006468 IDA involved_in protein phosphorylation 11096076,15983381 Process
4217 GO:0007254 IDA involved_in JNK cascade 11959862,21771788 Process
4217 GO:0007254 IMP involved_in JNK cascade 22095282 Process
4217 GO:0008631 IDA involved_in intrinsic apoptotic signaling pathway in response to oxidative stress 21771788,26095851 Process
4217 GO:0034198 IDA involved_in cellular response to amino acid starvation 11096076 Process
4217 GO:0034976 IMP involved_in response to endoplasmic reticulum stress 23000344 Process
4217 GO:0036480 IGI involved_in neuron intrinsic apoptotic signaling pathway in response to oxidative stress 15983381 Process
4217 GO:0043065 IDA involved_in positive regulation of apoptotic process 21771788 Process
4217 GO:0043280 IDA involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 20674765 Process
4217 GO:0043507 IMP involved_in positive regulation of JUN kinase activity 23000344 Process
4217 GO:0045860 IDA involved_in positive regulation of protein kinase activity 11959862 Process
4217 GO:0045893 IDA involved_in positive regulation of DNA-templated transcription 11096076 Process
4217 GO:0051403 IDA involved_in stress-activated MAPK cascade 11096076 Process
4217 GO:0070301 IDA involved_in cellular response to hydrogen peroxide 20674765 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4217 GO:0000287 IDA enables magnesium ion binding 17210579 Function
4217 GO:0004672 IDA enables protein kinase activity 11096076,21771788 Function
4217 GO:0004706 IDA enables JUN kinase kinase kinase activity 11959862 Function
4217 GO:0004709 IDA enables MAP kinase kinase kinase activity 17210579 Function
4217 GO:0005515 IPI enables protein binding 9743501,11003656,11154276,11298454,11495919,12556535,12813029,..... Function
4217 GO:0005524 IDA enables ATP binding 17210579 Function
4217 GO:0019903 IPI enables protein phosphatase binding 11959862,20674765 Function
4217 GO:0019904 IPI enables protein domain specific binding 11096076 Function
4217 GO:0042802 IPI enables identical protein binding 9743501,17937911,19805025 Function
4217 GO:0042803 IDA enables protein homodimerization activity 11920685 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4217 GO:0005737 IDA located_in cytoplasm 26095851 Component
4217 GO:0032991 IMP part_of protein-containing complex 11096076 Component
4217 GO:1902911 IDA part_of protein kinase complex 15983381 Component
4217 GO:1990604 IDA part_of IRE1-TRAF2-ASK1 complex 12050113,23000344 Component