Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4690
  • Symbol:NCK1
  • Description:NCK adaptor protein 1

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4690 GO:0000164 IDA part_of protein phosphatase type 1 complex 16835242 Component
4690 GO:0005737 IDA located_in cytoplasm 25468996 Component
4690 GO:0005783 IDA located_in endoplasmic reticulum 16835242 Component
4690 GO:0005829 IDA located_in cytosol Component
4690 GO:0005840 IDA located_in ribosome 11959995 Component
4690 GO:0005886 IDA located_in plasma membrane Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4690 GO:0004860 IDA enables protein kinase inhibitor activity 18835251 Function
4690 GO:0005102 IPI enables signaling receptor binding 12110186 Function
4690 GO:0005515 IPI enables protein binding 9346925,9697839,10026169,10206341,10229072,10521462,12620186,1..... Function
4690 GO:0030674 IDA enables protein-macromolecule adaptor activity 21707536 Function
4690 GO:0030971 IPI enables receptor tyrosine kinase binding 23358419 Function
4690 GO:0045296 HDA enables cadherin binding 25468996 Function
4690 GO:0071074 IPI enables eukaryotic initiation factor eIF2 binding 11959995 Function
4690 GO:0140693 IDA enables molecular condensate scaffold activity 26553976 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4690 GO:0030838 IMP involved_in positive regulation of actin filament polymerization 12110186 Process
4690 GO:0033137 IDA involved_in negative regulation of peptidyl-serine phosphorylation 14676213,16835242 Process
4690 GO:0036493 IDA involved_in positive regulation of translation in response to endoplasmic reticulum stress 14676213 Process
4690 GO:0042102 IMP involved_in positive regulation of T cell proliferation 12110186 Process
4690 GO:0042110 IMP involved_in T cell activation 12110186 Process
4690 GO:0045944 IDA involved_in positive regulation of transcription by RNA polymerase II 10026169 Process
4690 GO:0046627 IMP involved_in negative regulation of insulin receptor signaling pathway 21707536 Process
4690 GO:0070262 IDA involved_in peptidyl-serine dephosphorylation 16835242 Process
4690 GO:0140374 IDA involved_in antiviral innate immune response 18835251 Process
4690 GO:1902237 IDA involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 14676213 Process
4690 GO:1903676 IDA involved_in positive regulation of cap-dependent translational initiation 11959995 Process
4690 GO:1903679 IDA involved_in positive regulation of cap-independent translational initiation 11959995 Process
4690 GO:1903898 IDA involved_in negative regulation of PERK-mediated unfolded protein response 14676213 Process
4690 GO:1903912 IDA involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 14676213,16835242 Process
4690 GO:1990441 IDA involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 16835242 Process