Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:4734
  • Symbol:NEDD4
  • Description:NEDD4 E3 ubiquitin protein ligase

Component

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4734 GO:0000785 IDA part_of chromatin 17996703 Component
4734 GO:0005634 IDA located_in nucleus 11342538 Component
4734 GO:0005737 IDA located_in cytoplasm 11342538,12796489 Component
4734 GO:0005794 IDA located_in Golgi apparatus 16118794 Component
4734 GO:0005886 IDA located_in plasma membrane 16118794 Component
4734 GO:0005886 IMP located_in plasma membrane 15126635 Component
4734 GO:0005938 IDA located_in cell cortex 9990509 Component
4734 GO:0032991 IDA part_of protein-containing complex 17116753 Component
4734 GO:0048471 IDA located_in perinuclear region of cytoplasm 9990509 Component
4734 GO:0070062 HDA located_in extracellular exosome 23533145 Component

Function

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4734 GO:0005515 IPI enables protein binding 9305852,9990509,10642508,11359767,11598133,12796489,15231748,1..... Function
4734 GO:0019871 IDA enables sodium channel inhibitor activity 10642508 Function
4734 GO:0019899 IPI enables enzyme binding 26006083 Function
4734 GO:0019904 IPI enables protein domain specific binding 12907594 Function
4734 GO:0031698 IDA enables beta-2 adrenergic receptor binding 18544533 Function
4734 GO:0043130 IDA enables ubiquitin binding 9990509 Function
4734 GO:0061630 IDA enables ubiquitin protein ligase activity 11342538,17116753,17996703,20086093,26006083,34880843..... Function
4734 GO:0070063 IPI enables RNA polymerase binding 17996703 Function
4734 GO:0070064 IMP enables proline-rich region binding 15126635 Function
4734 GO:0070064 IPI enables proline-rich region binding 11342538 Function

Process

Export (tab separated) Export to Excel
GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
4734 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 11342538,20086093,26263374 Process
4734 GO:0006511 IMP involved_in ubiquitin-dependent protein catabolic process 17218260,17996703 Process
4734 GO:0006622 IPI involved_in protein targeting to lysosome 17116753 Process
4734 GO:0007041 IDA involved_in lysosomal transport 18544533 Process
4734 GO:0010766 IDA involved_in negative regulation of sodium ion transport 10642508 Process
4734 GO:0014068 IMP involved_in positive regulation of phosphatidylinositol 3-kinase signaling 17218260 Process
4734 GO:0016567 IDA acts_upstream_of_or_within protein ubiquitination 26280536 Process
4734 GO:0016567 IDA involved_in protein ubiquitination 17116753,17996703,18305167,25631046 Process
4734 GO:0031175 IEP involved_in neuron projection development 9990509 Process
4734 GO:0031623 IDA involved_in receptor internalization 18544533 Process
4734 GO:0032801 IDA involved_in receptor catabolic process 18544533 Process
4734 GO:0034644 IMP involved_in cellular response to UV 17996703 Process
4734 GO:0034765 IDA involved_in regulation of monoatomic ion transmembrane transport 17289006 Process
4734 GO:0042391 IDA involved_in regulation of membrane potential 17289006 Process
4734 GO:0042921 IDA involved_in glucocorticoid receptor signaling pathway 8649367 Process
4734 GO:0043162 IMP involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 20086093 Process
4734 GO:0044111 IMP involved_in formation of structure involved in a symbiotic process 15126635 Process
4734 GO:0045087 IDA acts_upstream_of_positive_effect innate immune response 23951545 Process
4734 GO:0045732 IDA acts_upstream_of_or_within positive regulation of protein catabolic process 14973438 Process
4734 GO:0046755 IMP acts_upstream_of viral budding 15126635 Process
4734 GO:0046824 IDA involved_in positive regulation of nucleocytoplasmic transport 17218261 Process
4734 GO:0050847 IDA involved_in progesterone receptor signaling pathway 8649367 Process
4734 GO:1901016 IDA involved_in regulation of potassium ion transmembrane transporter activity 17289006 Process
4734 GO:2000650 IDA involved_in negative regulation of sodium ion transmembrane transporter activity 10642508 Process