Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5058
  • Symbol:PAK1
  • Description:p21 (RAC1) activated kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5058 GO:0000165 IDA NOT involved_in MAPK cascade 8805275 Process
5058 GO:0001934 IMP involved_in positive regulation of protein phosphorylation 23633677 Process
5058 GO:0006338 IDA involved_in chromatin remodeling 23260667 Process
5058 GO:0006468 IDA involved_in protein phosphorylation 9852149,23260667 Process
5058 GO:0006974 IDA involved_in DNA damage response 23260667 Process
5058 GO:0008284 IMP involved_in positive regulation of cell population proliferation 23333386 Process
5058 GO:0016310 IDA involved_in phosphorylation 27012601 Process
5058 GO:0016477 IMP acts_upstream_of_or_within cell migration 27917469 Process
5058 GO:0030036 IDA involved_in actin cytoskeleton organization 9395435 Process
5058 GO:0030036 IMP acts_upstream_of_or_within actin cytoskeleton organization 27917469 Process
5058 GO:0030036 IMP involved_in actin cytoskeleton organization 16278681 Process
5058 GO:0030335 IDA involved_in positive regulation of cell migration 25766321 Process
5058 GO:0031116 IMP involved_in positive regulation of microtubule polymerization 25198505 Process
5058 GO:0033138 IDA involved_in positive regulation of peptidyl-serine phosphorylation 19667065 Process
5058 GO:0033148 IDA involved_in positive regulation of intracellular estrogen receptor signaling pathway 16278681 Process
5058 GO:0042060 IMP involved_in wound healing 12912914 Process
5058 GO:0043507 IMP involved_in positive regulation of JUN kinase activity 8805275 Process
5058 GO:0046777 IDA involved_in protein autophosphorylation 8805275 Process
5058 GO:0048012 IMP involved_in hepatocyte growth factor receptor signaling pathway 25198505 Process
5058 GO:0048754 IMP involved_in branching morphogenesis of an epithelial tube 20457839 Process
5058 GO:0051179 IDA involved_in localization 9659915,31391252 Process
5058 GO:0051179 IMP involved_in localization 31391252 Process
5058 GO:0051496 IMP involved_in positive regulation of stress fiber assembly 11864573 Process
5058 GO:0060244 IMP involved_in negative regulation of cell proliferation involved in contact inhibition 12912914 Process
5058 GO:0090063 IMP involved_in positive regulation of microtubule nucleation 27012601 Process
5058 GO:1903608 IDA involved_in protein localization to cytoplasmic stress granule 20417602 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5058 GO:0001726 IDA located_in ruffle 12912914 Component
5058 GO:0005654 IDA located_in nucleoplasm 23260667 Component
5058 GO:0005737 IDA located_in cytoplasm 16278681,23260667,25766321 Component
5058 GO:0005829 IDA located_in cytosol Component
5058 GO:0005884 IDA located_in actin filament 9395435 Component
5058 GO:0005886 IDA located_in plasma membrane 16278681 Component
5058 GO:0005911 IDA located_in cell-cell junction 12912914 Component
5058 GO:0032991 IDA part_of protein-containing complex 11864573,11950598 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5058 GO:0004672 IDA enables protein kinase activity 8805275,9852149 Function
5058 GO:0004674 EXP enables protein serine/threonine kinase activity 10559936,11278486,17060906 Function
5058 GO:0004674 IDA enables protein serine/threonine kinase activity 16278681,19667065,20417602,23260667 Function
5058 GO:0005515 IPI enables protein binding 9601050,10026169,10559936,11030651,11864573,12606577,12624090,..... Function
5058 GO:0005518 IPI enables collagen binding 12189148 Function
5058 GO:0031267 IPI contributes_to small GTPase binding 11950598 Function
5058 GO:0043015 IDA enables gamma-tubulin binding 27012601 Function
5058 GO:0060090 EXP enables molecular adaptor activity 10975528 Function
5058 GO:0140678 IDA enables molecular function inhibitor activity 10551809 Function