Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:51514
  • Symbol:DTL
  • Description:denticleless E3 ubiquitin protein ligase homolog

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
51514 GO:0000209 IDA involved_in protein polyubiquitination 18794347 Process
51514 GO:0006511 IDA involved_in ubiquitin-dependent protein catabolic process 18794347 Process
51514 GO:0006511 IMP involved_in ubiquitin-dependent protein catabolic process 26431207 Process
51514 GO:0006513 IDA involved_in protein monoubiquitination 20129063 Process
51514 GO:0006974 IDA involved_in DNA damage response 20129063 Process
51514 GO:0006974 IMP involved_in DNA damage response 16949367 Process
51514 GO:0007095 IMP involved_in mitotic G2 DNA damage checkpoint signaling 17085480 Process
51514 GO:0009411 IDA involved_in response to UV 18794347 Process
51514 GO:0010971 IMP involved_in positive regulation of G2/M transition of mitotic cell cycle 16949367 Process
51514 GO:0019985 IDA involved_in translesion synthesis 20129063 Process
51514 GO:0045732 IMP involved_in positive regulation of protein catabolic process 16949367 Process
51514 GO:0051726 IMP involved_in regulation of cell cycle 17085480 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
51514 GO:0004842 IDA contributes_to ubiquitin-protein transferase activity 18794347,20129063 Function
51514 GO:0005515 IPI enables protein binding 16949367,17041588,18794347,23213251,26431207,27906959,32814053..... Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
51514 GO:0005634 IDA located_in nucleus 17106265,26431207 Component
51514 GO:0005654 IDA located_in nucleoplasm Component
51514 GO:0005730 IDA located_in nucleolus Component
51514 GO:0005813 IDA located_in centrosome 17106265 Component
51514 GO:0005829 IDA located_in cytosol Component
51514 GO:0031464 IDA part_of Cul4A-RING E3 ubiquitin ligase complex 17085480,18794347,20129063,21628527 Component
51514 GO:0031465 IDA part_of Cul4B-RING E3 ubiquitin ligase complex 18794347 Component
51514 GO:0080008 IMP part_of Cul4-RING E3 ubiquitin ligase complex 16949367 Component