Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5170
  • Symbol:PDPK1
  • Description:3-phosphoinositide dependent protein kinase 1

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5170 GO:0004674 IDA enables protein serine/threonine kinase activity 9368760 Function
5170 GO:0004676 IDA enables 3-phosphoinositide-dependent protein kinase activity 9368760 Function
5170 GO:0005515 IPI enables protein binding 11438723,18616680,21075311,21775285,23397142,26256536,26593251..... Function
5170 GO:0016004 IMP enables phospholipase activator activity 22454520 Function
5170 GO:0043274 IPI enables phospholipase binding 22454520 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5170 GO:0005737 IDA located_in cytoplasm 9637919 Component
5170 GO:0005829 IDA located_in cytosol Component
5170 GO:0005886 IDA located_in plasma membrane 9637919,14749367,22454520 Component
5170 GO:0042995 IDA located_in cell projection 22454520 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5170 GO:0006468 IDA involved_in protein phosphorylation 14585963 Process
5170 GO:0006469 IDA involved_in negative regulation of protein kinase activity 9373175 Process
5170 GO:0007173 IMP involved_in epidermal growth factor receptor signaling pathway 22454520 Process
5170 GO:0010518 IMP involved_in positive regulation of phospholipase activity 22454520 Process
5170 GO:0016477 IMP involved_in cell migration 22454520 Process
5170 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 9368760 Process
5170 GO:0019722 IMP involved_in calcium-mediated signaling 22454520 Process
5170 GO:0030512 IDA involved_in negative regulation of transforming growth factor beta receptor signaling pathway 17327236 Process
5170 GO:0032148 IDA involved_in activation of protein kinase B activity 9368760 Process
5170 GO:0032869 IMP involved_in cellular response to insulin stimulus 10567711 Process
5170 GO:0035556 IDA acts_upstream_of_or_within intracellular signal transduction 14749367 Process
5170 GO:0043122 IMP involved_in regulation of I-kappaB kinase/NF-kappaB signaling 16207722 Process
5170 GO:0043536 IMP involved_in positive regulation of blood vessel endothelial cell migration 23802567 Process
5170 GO:0045766 IMP involved_in positive regulation of angiogenesis 23802567 Process
5170 GO:0051281 IDA involved_in positive regulation of release of sequestered calcium ion into cytosol 22454520 Process
5170 GO:0071364 IMP involved_in cellular response to epidermal growth factor stimulus 22454520 Process
5170 GO:0097191 IMP involved_in extrinsic apoptotic signaling pathway 16207722 Process
5170 GO:1903078 IMP involved_in positive regulation of protein localization to plasma membrane 10567711 Process
5170 GO:1903672 IMP involved_in positive regulation of sprouting angiogenesis 26235810 Process
5170 GO:1905564 IMP involved_in positive regulation of vascular endothelial cell proliferation 23802567 Process
5170 GO:2000352 IMP involved_in negative regulation of endothelial cell apoptotic process 26235810 Process