Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5291
  • Symbol:PIK3CB
  • Description:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5291 GO:0001952 IMP acts_upstream_of_or_within regulation of cell-matrix adhesion 25139353 Process
5291 GO:0003376 IMP involved_in sphingosine-1-phosphate receptor signaling pathway 18558630 Process
5291 GO:0010595 IGI involved_in positive regulation of endothelial cell migration 18558630 Process
5291 GO:0010628 IMP acts_upstream_of_or_within positive regulation of gene expression 25139353 Process
5291 GO:0014065 IGI involved_in phosphatidylinositol 3-kinase signaling 30496354 Process
5291 GO:0014065 IMP involved_in phosphatidylinositol 3-kinase signaling 18558630,25339672 Process
5291 GO:0016310 IDA acts_upstream_of_or_within phosphorylation 25327288 Process
5291 GO:0033031 IMP involved_in positive regulation of neutrophil apoptotic process 25339672 Process
5291 GO:0035022 IGI involved_in positive regulation of Rac protein signal transduction 18558630 Process
5291 GO:0046854 IDA involved_in phosphatidylinositol phosphate biosynthetic process 12502714 Process
5291 GO:0051000 IMP acts_upstream_of positive regulation of nitric-oxide synthase activity 18558630 Process
5291 GO:0051897 IMP involved_in positive regulation of protein kinase B signaling 18558630 Process
5291 GO:0051898 IGI involved_in negative regulation of protein kinase B signaling 30496354 Process
5291 GO:1900747 IGI involved_in negative regulation of vascular endothelial growth factor signaling pathway 30496354 Process
5291 GO:1903671 IMP involved_in negative regulation of sprouting angiogenesis 30496354 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5291 GO:0005515 IPI enables protein binding 19380743,20713702,22402981,25241761,25556234,25814554,26496610..... Function
5291 GO:0016301 IDA enables kinase activity 25327288 Function
5291 GO:0046934 IDA enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity 12502714 Function
5291 GO:0106310 IDA enables protein serine kinase activity 12502714 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5291 GO:0005634 IDA located_in nucleus 30496354 Component
5291 GO:0005654 IDA located_in nucleoplasm Component
5291 GO:0005730 IDA located_in nucleolus Component
5291 GO:0005943 IPI part_of phosphatidylinositol 3-kinase complex, class IA 20713702,22402981 Component
5291 GO:0030496 IDA located_in midbody Component
5291 GO:0043231 IDA located_in intracellular membrane-bounded organelle Component