Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5335
  • Symbol:PLCG1
  • Description:phospholipase C gamma 1

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5335 GO:0001726 IDA located_in ruffle 17229814 Component
5335 GO:0005737 IDA located_in cytoplasm 15702972 Component
5335 GO:0005829 IDA located_in cytosol 2550068 Component
5335 GO:0005886 IDA is_active_in plasma membrane 20510673 Component
5335 GO:0005886 IDA located_in plasma membrane 2550068,22454520 Component
5335 GO:0008180 IDA part_of COP9 signalosome 22561606 Component
5335 GO:0030027 IDA located_in lamellipodium 17229814 Component
5335 GO:0032587 IDA is_active_in ruffle membrane 11331309 Component
5335 GO:0042995 IDA located_in cell projection 22454520 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5335 GO:0004435 IDA enables phosphatidylinositol phospholipase C activity 2550068 Function
5335 GO:0004629 IDA enables phospholipase C activity 20510673 Function
5335 GO:0005168 IPI enables neurotrophin TRKA receptor binding 15488758 Function
5335 GO:0005515 IPI enables protein binding 1396585,1656221,7537096,7537265,7693694,7993895,8321198,838455..... Function
5335 GO:0019901 IPI enables protein kinase binding 22454520 Function

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5335 GO:0007173 IMP involved_in epidermal growth factor receptor signaling pathway 22454520 Process
5335 GO:0010634 IMP involved_in positive regulation of epithelial cell migration 17229814 Process
5335 GO:0016477 IMP involved_in cell migration 22454520 Process
5335 GO:0019722 IMP involved_in calcium-mediated signaling 22454520 Process
5335 GO:0043536 IDA involved_in positive regulation of blood vessel endothelial cell migration 20011604 Process
5335 GO:0045766 IDA involved_in positive regulation of angiogenesis 20011604 Process
5335 GO:0051281 IMP involved_in positive regulation of release of sequestered calcium ion into cytosol 22454520 Process
5335 GO:0071364 IDA involved_in cellular response to epidermal growth factor stimulus 17229814 Process
5335 GO:0071364 IMP involved_in cellular response to epidermal growth factor stimulus 22454520 Process
5335 GO:1905564 IMP involved_in positive regulation of vascular endothelial cell proliferation 27464494 Process
5335 GO:2000353 IMP involved_in positive regulation of endothelial cell apoptotic process 27464494 Process