Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5347
  • Symbol:PLK1
  • Description:polo like kinase 1

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5347 GO:0000070 IMP involved_in mitotic sister chromatid segregation 23455478 Process
5347 GO:0000086 IDA involved_in G2/M transition of mitotic cell cycle 19160488 Process
5347 GO:0000122 IMP involved_in negative regulation of transcription by RNA polymerase II 18174154 Process
5347 GO:0000132 IDA involved_in establishment of mitotic spindle orientation 23509069 Process
5347 GO:0000278 IDA involved_in mitotic cell cycle 18615013 Process
5347 GO:0000278 IMP involved_in mitotic cell cycle 18477460 Process
5347 GO:0000281 IDA involved_in mitotic cytokinesis 19468302 Process
5347 GO:0001578 IDA involved_in microtubule bundle formation 12939256 Process
5347 GO:0006468 IDA involved_in protein phosphorylation 19468300,20679239,22701722,23509069 Process
5347 GO:0006468 IMP involved_in protein phosphorylation 17461553 Process
5347 GO:0007094 IMP involved_in mitotic spindle assembly checkpoint signaling 23455478 Process
5347 GO:0007095 IDA involved_in mitotic G2 DNA damage checkpoint signaling 18662541 Process
5347 GO:0007098 IMP involved_in centrosome cycle 8991084,18477460 Process
5347 GO:0007346 IMP involved_in regulation of mitotic cell cycle 17495026 Process
5347 GO:0010800 IMP involved_in positive regulation of peptidyl-threonine phosphorylation 21041660 Process
5347 GO:0016567 IDA involved_in protein ubiquitination 16885022 Process
5347 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 16885022 Process
5347 GO:0030071 IDA involved_in regulation of mitotic metaphase/anaphase transition 23509069 Process
5347 GO:0030071 IMP involved_in regulation of mitotic metaphase/anaphase transition 21041660 Process
5347 GO:0031648 IDA involved_in protein destabilization 16885022 Process
5347 GO:0032436 IMP involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 19473992 Process
5347 GO:0032465 IDA involved_in regulation of cytokinesis 17351640 Process
5347 GO:0032465 IMP involved_in regulation of cytokinesis 12939256 Process
5347 GO:0043066 IMP involved_in negative regulation of apoptotic process 18174154 Process
5347 GO:0043393 IMP involved_in regulation of protein binding 21041660 Process
5347 GO:0045184 IMP acts_upstream_of_or_within establishment of protein localization 18331714 Process
5347 GO:0045736 IMP involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity 21041660 Process
5347 GO:0045862 IDA involved_in positive regulation of proteolysis 16885022 Process
5347 GO:0051081 IMP involved_in nuclear membrane disassembly 20679239 Process
5347 GO:0051443 IMP involved_in positive regulation of ubiquitin-protein transferase activity 19473992 Process
5347 GO:0071168 IDA involved_in protein localization to chromatin 21111234 Process
5347 GO:0090435 IMP involved_in protein localization to nuclear envelope 20679239 Process
5347 GO:1901673 IDA involved_in regulation of mitotic spindle assembly 22621898 Process
5347 GO:1904668 IDA involved_in positive regulation of ubiquitin protein ligase activity 15148369 Process
5347 GO:1904776 IDA involved_in regulation of protein localization to cell cortex 23509069 Process

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5347 GO:0000287 IMP enables magnesium ion binding 17461553 Function
5347 GO:0004672 IDA enables protein kinase activity 17146433,19596235,22854038 Function
5347 GO:0004672 IMP enables protein kinase activity 17461553 Function
5347 GO:0004674 EXP enables protein serine/threonine kinase activity 18378770,20577264 Function
5347 GO:0004674 IDA enables protein serine/threonine kinase activity 12524548,12939256,15148369,17351640,18174154,18477460,19160488..... Function
5347 GO:0004674 IMP enables protein serine/threonine kinase activity 19473992,21041660,23455478 Function
5347 GO:0005515 IPI enables protein binding 12493754,12524548,12939256,15070733,15148369,15654075,16439210..... Function
5347 GO:0005524 IMP enables ATP binding 17461553 Function
5347 GO:0008017 IDA enables microtubule binding 12939256 Function
5347 GO:0010997 IPI enables anaphase-promoting complex binding 18662541 Function
5347 GO:0019901 IPI enables protein kinase binding 12639966,18615013,21041660 Function
5347 GO:0042802 IPI enables identical protein binding 21041660,23354166,26192437 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5347 GO:0000776 IDA located_in kinetochore 17617734,18477460,18615013,21041660,23455478,24157919,25395579..... Component
5347 GO:0000922 IDA located_in spindle pole 18331714,21041660 Component
5347 GO:0000940 IDA part_of outer kinetochore 18195732 Component
5347 GO:0005634 IDA located_in nucleus 18615013 Component
5347 GO:0005813 IDA located_in centrosome 8991084,12524548,18477460,18615013,21041660,21399614,23455478,..... Component
5347 GO:0005819 IDA located_in spindle 12939256,17351640 Component
5347 GO:0005876 IDA colocalizes_with spindle microtubule 21041660 Component
5347 GO:0015630 IDA located_in microtubule cytoskeleton 21041660 Component
5347 GO:0030496 IDA located_in midbody 19468300 Component
5347 GO:0051233 IDA located_in spindle midzone 19468302,21041660 Component