Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5591
  • Symbol:PRKDC
  • Description:protein kinase, DNA-activated, catalytic subunit

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5591 GO:0000460 IDA involved_in maturation of 5.8S rRNA 32103174 Process
5591 GO:0002218 IDA involved_in activation of innate immune response 28712728 Process
5591 GO:0006302 IMP involved_in double-strand break repair 18710952 Process
5591 GO:0006468 IDA involved_in protein phosphorylation 26237645 Process
5591 GO:0006468 IMP involved_in protein phosphorylation 22504299 Process
5591 GO:0006974 IDA involved_in DNA damage response 26237645,29478807,35460603 Process
5591 GO:0016233 IMP involved_in telomere capping 18710952 Process
5591 GO:0018105 IDA acts_upstream_of_or_within peptidyl-serine phosphorylation 15194694 Process
5591 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 19303849,32103174 Process
5591 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 32103174 Process
5591 GO:0031571 IMP involved_in mitotic G1 DNA damage checkpoint signaling 21731742 Process
5591 GO:0032869 IMP involved_in cellular response to insulin stimulus 19303849 Process
5591 GO:0034462 IDA involved_in small-subunit processome assembly 32103174 Process
5591 GO:0043066 IMP involved_in negative regulation of apoptotic process 24485452 Process
5591 GO:0045824 IDA involved_in negative regulation of innate immune response 33273464 Process
5591 GO:0045944 IMP involved_in positive regulation of transcription by RNA polymerase II 19303849 Process
5591 GO:0048660 IMP involved_in regulation of smooth muscle cell proliferation 25852083 Process
5591 GO:0050678 IMP involved_in regulation of epithelial cell proliferation 18710952 Process
5591 GO:2001034 IDA involved_in positive regulation of double-strand break repair via nonhomologous end joining 26237645 Process

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5591 GO:0000781 HDA located_in chromosome, telomeric region 19135898 Component
5591 GO:0000785 IDA part_of chromatin 29478807 Component
5591 GO:0005634 IDA located_in nucleus 22504299,32103174 Component
5591 GO:0005654 IDA located_in nucleoplasm Component
5591 GO:0005667 IDA part_of transcription regulator complex 19303849 Component
5591 GO:0005730 IDA located_in nucleolus 27829214,32103174 Component
5591 GO:0005958 IDA part_of DNA-dependent protein kinase-DNA ligase 4 complex 15194694 Component
5591 GO:0016020 HDA located_in membrane 19946888 Component
5591 GO:0032040 IDA part_of small-subunit processome 32103174 Component
5591 GO:0032991 IMP part_of protein-containing complex 22504299 Component
5591 GO:0032993 IDA part_of protein-DNA complex 22504299 Component
5591 GO:0070418 IPI part_of DNA-dependent protein kinase complex 28840859 Component
5591 GO:0070419 IDA part_of nonhomologous end joining complex 20383123,25941166 Component

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5591 GO:0003690 IDA enables double-stranded DNA binding 22504299 Function
5591 GO:0003723 HDA enables RNA binding 22658674,22681889 Function
5591 GO:0004672 IDA enables protein kinase activity 7671312 Function
5591 GO:0004672 IMP enables protein kinase activity 22504299 Function
5591 GO:0004674 IDA enables protein serine/threonine kinase activity 19303849,24485452,26237645,29478807,32103174,33273464,35460603..... Function
5591 GO:0004677 IDA enables DNA-dependent protein kinase activity 15194694 Function
5591 GO:0005515 IPI enables protein binding 9442054,17308091,18026119,19303849,19833092,20023628,20085707,..... Function
5591 GO:0019904 IPI enables protein domain specific binding 22504299 Function
5591 GO:0034511 IDA enables U3 snoRNA binding 32103174 Function
5591 GO:0061629 IPI enables RNA polymerase II-specific DNA-binding transcription factor binding 19303849 Function