Gene Ontology

Gene Info

  • Species:Human (Homo sapiens)
  • GeneID:5599
  • Symbol:MAPK8
  • Description:mitogen-activated protein kinase 8

Function

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5599 GO:0004674 IDA enables protein serine/threonine kinase activity 14967141,15850461,20027304,21095239,22966201,27568560,28943315..... Function
5599 GO:0004705 IDA enables JUN kinase activity 8654373,21095239 Function
5599 GO:0005515 IPI enables protein binding 10393177,10490659,10747973,10856240,11517249,15334056,15894542..... Function
5599 GO:0019899 IPI enables enzyme binding 14615289 Function
5599 GO:0019903 IPI enables protein phosphatase binding 11489891 Function
5599 GO:0035033 IMP enables histone deacetylase regulator activity 20027304 Function
5599 GO:0042826 IPI enables histone deacetylase binding 20027304 Function
5599 GO:0120283 IPI enables protein serine/threonine kinase binding 11865055 Function

Component

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5599 GO:0005634 IDA located_in nucleus 20027304,30878395 Component

Process

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GeneID GO_ID Evidence Qualifier GO_term Pubmed ID Category
5599 GO:0006468 IDA involved_in protein phosphorylation 21856198 Process
5599 GO:0006468 IMP involved_in protein phosphorylation 22441692 Process
5599 GO:0006979 IDA involved_in response to oxidative stress 22966201 Process
5599 GO:0007254 IDA involved_in JNK cascade 8654373 Process
5599 GO:0007258 IDA acts_upstream_of_or_within JUN phosphorylation 14967141 Process
5599 GO:0007258 IDA involved_in JUN phosphorylation 21095239 Process
5599 GO:0009411 IDA acts_upstream_of_or_within response to UV 14967141 Process
5599 GO:0010628 IMP involved_in positive regulation of gene expression 22065586 Process
5599 GO:0018105 IDA involved_in peptidyl-serine phosphorylation 15850461,20027304,21095239,22966201 Process
5599 GO:0018107 IDA involved_in peptidyl-threonine phosphorylation 21095239 Process
5599 GO:0018107 IMP involved_in peptidyl-threonine phosphorylation 20027304 Process
5599 GO:0031281 IMP involved_in positive regulation of cyclase activity 22027397 Process
5599 GO:0032091 IDA involved_in negative regulation of protein binding 21095239 Process
5599 GO:0032880 IDA involved_in regulation of protein localization 20027304 Process
5599 GO:0034198 IDA involved_in cellular response to amino acid starvation 11096076 Process
5599 GO:0034599 IDA involved_in cellular response to oxidative stress 27568560 Process
5599 GO:0034614 IMP involved_in cellular response to reactive oxygen species 26514923 Process
5599 GO:0043066 IDA acts_upstream_of_or_within negative regulation of apoptotic process 14967141 Process
5599 GO:0043066 IDA involved_in negative regulation of apoptotic process 21095239 Process
5599 GO:0051247 IMP involved_in positive regulation of protein metabolic process 22027397 Process
5599 GO:0051403 IDA involved_in stress-activated MAPK cascade 11096076 Process
5599 GO:0071222 IDA acts_upstream_of_or_within cellular response to lipopolysaccharide 23776175 Process
5599 GO:0071260 IEP involved_in cellular response to mechanical stimulus 19593445 Process
5599 GO:0071276 IMP involved_in cellular response to cadmium ion 26514923 Process
5599 GO:0090045 IMP involved_in positive regulation of deacetylase activity 20027304 Process
5599 GO:1900227 IDA involved_in positive regulation of NLRP3 inflammasome complex assembly 28943315 Process
5599 GO:1902595 IMP involved_in regulation of DNA replication origin binding 21856198 Process